Unveiling major histocompatibility complex-mediated pan-cancer immune features by integrated single-cell and bulk RNA sequencing

Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, yet persistent challenges such as low response rate and significant heterogeneity necessitate attention. The pivotal role of the major histocompatibility complex (MHC) in ICI efficacy, its intricate impacts and potentials as a prog...

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Veröffentlicht in:	Cancer letters 2024-08, Vol.597, p.217062, Article 217062
Hauptverfasser:	Feng, Hao-Ran, Shen, Xiao-Nan, Zhu, Xiao-Ming, Zhong, Wen-Tao, Zhu, De-Xiang, Zhao, Ji, Chen, Yan-Jie, Shen, Feng, Liu, Kun, Liang, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-tumor immunity Immune checkpoint inhibitors Major histocompatibility complex Pan-cancer scRNA-seq
Online-Zugang:	Volltext
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