Electron transport chain inhibition increases cellular dependence on purine transport and salvage

Mitochondria house many metabolic pathways required for homeostasis and growth. To explore how human cells respond to mitochondrial dysfunction, we performed metabolomics in fibroblasts from patients with various mitochondrial disorders and cancer cells with electron transport chain (ETC) blockade....

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Veröffentlicht in:	Cell metabolism 2024-07, Vol.36 (7), p.1504-1520.e9
Hauptverfasser:	Wu, Zheng, Bezwada, Divya, Cai, Feng, Harris, Robert C., Ko, Bookyung, Sondhi, Varun, Pan, Chunxiao, Vu, Hieu S., Nguyen, Phong T., Faubert, Brandon, Cai, Ling, Chen, Hongli, Martin-Sandoval, Misty, Do, Duyen, Gu, Wen, Zhang, Yuanyuan, Zhang, Yuannyu, Brooks, Bailey, Kelekar, Sherwin, Zacharias, Lauren G., Oaxaca, K. Celeste, Patricio, Joao S., Mathews, Thomas P., Garcia-Bermudez, Javier, Ni, Min, DeBerardinis, Ralph J.
Format:	Artikel
Sprache:	eng
Schlagworte:	electron transport chain HPRT1 metabolomics NAD+:NADH ratio purine metabolism stable isotopes
Online-Zugang:	Volltext
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