Doublet chemotherapy, triplet chemotherapy, or doublet chemotherapy combined with radiotherapy as neoadjuvant treatment for locally advanced oesophageal cancer (JCOG1109 NExT): a randomised, controlled, open-label, phase 3 trial

Neoadjuvant therapy is the standard treatment for patients with locally advanced oesophageal squamous cell carcinoma (OSCC). However, the prognosis remains poor and more intensive neoadjuvant treatment might be needed to improve patient outcomes. We therefore aimed to compare the efficacy and safety...

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Veröffentlicht in:	The Lancet (British edition) 2024-07, Vol.404 (10447), p.55-66
Hauptverfasser:	Kato, Ken, Machida, Ryunosuke, Ito, Yoshinori, Daiko, Hiroyuki, Ozawa, Soji, Ogata, Takashi, Hara, Hiroki, Kojima, Takashi, Abe, Tetsuya, Bamba, Takeo, Watanabe, Masaya, Kawakubo, Hirofumi, Shibuya, Yuichi, Tsubosa, Yasuhiro, Takegawa, Naoki, Kajiwara, Takeshi, Baba, Hideo, Ueno, Masaki, Takeuchi, Hiroya, Nakamura, Kenichi, Kitagawa, Yuko, Komatsu, Yoshito, Akiyama, Yuji, Takahashi, Masanobu, Amagai, Kenji, Matsushita, Naoyuki, Sato, Hiroshi, Minashi, Keiko, Matsubara, Hisahiro, Kikuchi, Yuji, Narumiya, Kosuke, Kubota, Yutaro, Watanabe, Masayuki, Ichikawa, Hiroshi, Koike, Masahiko, Tsunoda, Shigeru, Doki, Yuichiro, Miyata, Hiroshi, Hirano, Motohiro, Ikeda, Hiroko, Goto, Masahiro, Minami, Hironobu, Masuzawa, Toru, Tsuda, Masahiro, Okada, Morihito, Mukai, Hidenori, Morita, Masaru, Baba, Eishi, Inomata, Masafumi, Sasaki, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Anastomotic leak Cancer Cancer therapies Chemotherapy Cisplatin Clinical trials Effectiveness Esophageal cancer Esophageal carcinoma Fatalities Gastrointestinal cancer Health services Labels Lymph nodes Lymphatic system Medical prognosis Medical research Metastasis Neutropenia Nutritional status Oncology Ostomy Paralysis Patients R&D Radiation therapy Randomization Research & development Squamous cell carcinoma Statistical analysis Surgery Surgical anastomosis Survival
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