Ursolic acid improved demyelination and interstitial fluid drainage disorders in schizophrenia mice
To unveil the pathological changes associated with demyelination in schizophrenia (SZ) and its consequential impact on interstitial fluid (ISF) drainage, and to investigate the therapeutic efficacy of ursolic acid (UA) in treating demyelination and the ensuing abnormalities in ISF drainage in SZ. Fe...
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| Veröffentlicht in: | Beijing da xue xue bao. Journal of Peking University. Yi xue ban 2024-06, Vol.56 (3), p.487 |
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| container_title | Beijing da xue xue bao. Journal of Peking University. Yi xue ban |
| container_volume | 56 |
| creator | Long, Ren Mao, Xin Gao, Tianzi Xie, Qian Tan, Hanbo Li, Ziyin Han, Hongbin Yuan, Lan |
| description | To unveil the pathological changes associated with demyelination in schizophrenia (SZ) and its consequential impact on interstitial fluid (ISF) drainage, and to investigate the therapeutic efficacy of ursolic acid (UA) in treating demyelination and the ensuing abnormalities in ISF drainage in SZ.
Female C57BL/6J mice, aged 6-8 weeks and weighing (20±2) g, were randomly divided into three groups: control, SZ model, and UA treatment. The control group received intraperitoneal injection (ip) of physiological saline and intragastric administration (ig) of 1% carboxymethylcellulose sodium (CMC-Na). The SZ model group was subjected to ip injection of 2 mg/kg dizocilpine maleate (MK-801) and ig administration of 1% CMC-Na. The UA treatment group underwent ig administration of 25 mg/kg UA and ip injection of 2 mg/kg MK-801. The treatment group received UA pretreatment via ig administration for one week, followed by a two-week drug intervention for all the three groups. Behavioral assessments, including the open field |
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Female C57BL/6J mice, aged 6-8 weeks and weighing (20±2) g, were randomly divided into three groups: control, SZ model, and UA treatment. The control group received intraperitoneal injection (ip) of physiological saline and intragastric administration (ig) of 1% carboxymethylcellulose sodium (CMC-Na). The SZ model group was subjected to ip injection of 2 mg/kg dizocilpine maleate (MK-801) and ig administration of 1% CMC-Na. The UA treatment group underwent ig administration of 25 mg/kg UA and ip injection of 2 mg/kg MK-801. The treatment group received UA pretreatment via ig administration for one week, followed by a two-week drug intervention for all the three groups. Behavioral assessments, including the open field</description><identifier>ISSN: 1671-167X</identifier><identifier>PMID: 38864135</identifier><language>chi</language><publisher>China</publisher><subject>Animals ; Aquaporin 4 - metabolism ; Demyelinating Diseases - drug therapy ; Disease Models, Animal ; Dizocilpine Maleate ; Extracellular Fluid - drug effects ; Extracellular Fluid - metabolism ; Female ; Mice ; Mice, Inbred C57BL ; Schizophrenia - drug therapy ; Triterpenes - pharmacology ; Triterpenes - therapeutic use ; Ursolic Acid</subject><ispartof>Beijing da xue xue bao. Journal of Peking University. Yi xue ban, 2024-06, Vol.56 (3), p.487</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38864135$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Long, Ren</creatorcontrib><creatorcontrib>Mao, Xin</creatorcontrib><creatorcontrib>Gao, Tianzi</creatorcontrib><creatorcontrib>Xie, Qian</creatorcontrib><creatorcontrib>Tan, Hanbo</creatorcontrib><creatorcontrib>Li, Ziyin</creatorcontrib><creatorcontrib>Han, Hongbin</creatorcontrib><creatorcontrib>Yuan, Lan</creatorcontrib><title>Ursolic acid improved demyelination and interstitial fluid drainage disorders in schizophrenia mice</title><title>Beijing da xue xue bao. Journal of Peking University. Yi xue ban</title><addtitle>Beijing Da Xue Xue Bao Yi Xue Ban</addtitle><description>To unveil the pathological changes associated with demyelination in schizophrenia (SZ) and its consequential impact on interstitial fluid (ISF) drainage, and to investigate the therapeutic efficacy of ursolic acid (UA) in treating demyelination and the ensuing abnormalities in ISF drainage in SZ.
Female C57BL/6J mice, aged 6-8 weeks and weighing (20±2) g, were randomly divided into three groups: control, SZ model, and UA treatment. The control group received intraperitoneal injection (ip) of physiological saline and intragastric administration (ig) of 1% carboxymethylcellulose sodium (CMC-Na). The SZ model group was subjected to ip injection of 2 mg/kg dizocilpine maleate (MK-801) and ig administration of 1% CMC-Na. The UA treatment group underwent ig administration of 25 mg/kg UA and ip injection of 2 mg/kg MK-801. The treatment group received UA pretreatment via ig administration for one week, followed by a two-week drug intervention for all the three groups. 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Yi xue ban</jtitle><addtitle>Beijing Da Xue Xue Bao Yi Xue Ban</addtitle><date>2024-06-18</date><risdate>2024</risdate><volume>56</volume><issue>3</issue><spage>487</spage><pages>487-</pages><issn>1671-167X</issn><abstract>To unveil the pathological changes associated with demyelination in schizophrenia (SZ) and its consequential impact on interstitial fluid (ISF) drainage, and to investigate the therapeutic efficacy of ursolic acid (UA) in treating demyelination and the ensuing abnormalities in ISF drainage in SZ.
Female C57BL/6J mice, aged 6-8 weeks and weighing (20±2) g, were randomly divided into three groups: control, SZ model, and UA treatment. The control group received intraperitoneal injection (ip) of physiological saline and intragastric administration (ig) of 1% carboxymethylcellulose sodium (CMC-Na). The SZ model group was subjected to ip injection of 2 mg/kg dizocilpine maleate (MK-801) and ig administration of 1% CMC-Na. The UA treatment group underwent ig administration of 25 mg/kg UA and ip injection of 2 mg/kg MK-801. The treatment group received UA pretreatment via ig administration for one week, followed by a two-week drug intervention for all the three groups. Behavioral assessments, including the open field</abstract><cop>China</cop><pmid>38864135</pmid></addata></record> |
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| ispartof | Beijing da xue xue bao. Journal of Peking University. Yi xue ban, 2024-06, Vol.56 (3), p.487 |
| issn | 1671-167X |
| language | chi |
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| source | PubMed Central (Open Access); MEDLINE; EZB Electronic Journals Library |
| subjects | Animals Aquaporin 4 - metabolism Demyelinating Diseases - drug therapy Disease Models, Animal Dizocilpine Maleate Extracellular Fluid - drug effects Extracellular Fluid - metabolism Female Mice Mice, Inbred C57BL Schizophrenia - drug therapy Triterpenes - pharmacology Triterpenes - therapeutic use Ursolic Acid |
| title | Ursolic acid improved demyelination and interstitial fluid drainage disorders in schizophrenia mice |
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