Chloranthalactone B covalently binds to the NACHT domain of NLRP3 to attenuate NLRP3-driven inflammation

[Display omitted] NLRP3 inflammasome plays an important role in autoimmunity and the dysregulation of NLRP3 inflammasome can lead to various human diseases. Natural products are an important source for the discovery of safe and effective inflammatory inhibitors. Chloranthalactone B (CTB), a lindenan...

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Veröffentlicht in:	Biochemical pharmacology 2024-08, Vol.226, p.116360, Article 116360
Hauptverfasser:	Tang, Pengfei, Zhao, Shuai, Wang, Xiaoli, Wang, Siyuan, Wang, Yongyue, Kong, Lingyi, Luo, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Chloranthalactone B Covalent bind Epoxide motif NACHT domain Sarcandra glabra
Online-Zugang:	Volltext
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