miR-504 knockout regulates tumor cell proliferation and immune cell infiltration to accelerate oral cancer development

miR-504 plays a pivotal role in the progression of oral cancer. However, the underlying mechanism remains elusive in vivo. Here, we find that miR-504 is significantly down-regulated in oral cancer patients. We generate miR-504 knockout mice (miR-504−/−) using CRISPR/Cas9 technology to investigate it...

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Veröffentlicht in:	Journal of genetics and genomics 2024-10, Vol.51 (10), p.1040-1054
Hauptverfasser:	Wang, Xiaotang, Song, Xiaona, Ma, Yunhui, Yang, Junting, Gao, Jiping, Wang, Tian, Xu, Guoqiang, Chang, Xiaoqi, Shi, Shuxuan, Sun, Rui, Song, Guohua
Format:	Artikel
Sprache:	eng
Schlagworte:	4NQO CRISPR/Cas9 Lipid metabolism Malignant proliferation miR-504 Oral cancer animal model
Online-Zugang:	Volltext
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