Genetic variation near GRB10 associated with bone growth and osteosarcoma risk in canine and human populations

Canine and human osteosarcoma are similar in clinical presentation and tumor genomics. Giant breed dogs experience elevated osteosarcoma incidence, and taller stature remains a consistent risk factor for human osteosarcoma. Whether evolutionarily conserved genes contribute to both human and canine o...

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Veröffentlicht in:	Cancer epidemiology 2024-10, Vol.92, p.102599, Article 102599
Hauptverfasser:	Lucas, Sydney E., Yang, Tianzhong, Wimberly, Courtney E., Parmar, Kajal V., Hansen, Helen M., de Smith, Adam J., Morimoto, Libby M., Metayer, Catherine, Ostrom, Quinn T., Eward, William C., Graves, Laurie A., Wagner, Lars M., Wiemels, Joseph L., Spector, Logan G., Walsh, Kyle M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Alleles Animals Body height Bone cancer Bone growth Bone Neoplasms - epidemiology Bone Neoplasms - genetics Bone Neoplasms - veterinary Bones Case-Control Studies Child Children Chromosome 7 Comparative oncology Consortia Disease Dog Diseases - epidemiology Dog Diseases - genetics Dogs Domestic animals Ethnicity Female Gene mapping Genetic diversity Genetic Predisposition to Disease Genetic testing Genome-Wide Association Study Genomes Genotyping GRB10 Adaptor Protein - genetics Growth factor receptor bound protein 10 Haplotypes Hispanic Americans Humans Insulin-like growth factor receptor Male Medical screening Oncology Open source software Osteosarcoma Osteosarcoma - epidemiology Osteosarcoma - genetics Osteosarcoma - veterinary Pediatrics Polymorphism, Single Nucleotide Population genetics Protein folding Public health Race Risk Factors Sarcoma Single-nucleotide polymorphism
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