Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction

Polycystic ovary syndrome (PCOS), a prevalent reproductive disorder in women of reproductive age, features androgen excess, ovulatory dysfunction, and polycystic ovaries. Despite its high prevalence, specific pharmacologic intervention for PCOS is challenging. In this study, we identified artemisini...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2024-06, Vol.384 (6701), p.eadk5382
Hauptverfasser:	Liu, Yang, Jiang, Jing-Jing, Du, Shao-Yue, Mu, Liang-Shan, Fan, Jian-Jun, Hu, Jun-Chi, Ye, Yao, Ding, Meng, Zhou, Wei-Yu, Yu, Qiu-Han, Xia, Yi-Fan, Xu, Hong-Yu, Shi, Yi-Jie, Qian, Shu-Wen, Tang, Yan, Li, Wei, Dang, Yong-Jun, Dong, Xi, Li, Xiao-Ying, Xu, Cong-Jian, Tang, Qi-Qun
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Adipocytes Adult Androgens Androgens - metabolism Animal models Animals Artemether Artemisinin Artemisinins - pharmacology Artemisinins - therapeutic use ATP-Dependent Proteases - genetics ATP-Dependent Proteases - metabolism Binding Cholesterol Side-Chain Cleavage Enzyme - genetics Cholesterol Side-Chain Cleavage Enzyme - metabolism Cytochrome P450 Cytochromes P450 Degradation Dihydroartemisinin Disease Models, Animal Effectiveness Endocrine disorders Energy expenditure Estrus cycle Female Fertility Health services Humans Hyperandrogenism - drug therapy Hyperandrogenism - metabolism In vivo methods and tests Infertility Malaria Medical innovations Menstrual cycle Menstruation Metabolic disorders Mice Mice, Inbred C57BL Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Morphology Obesity Ovaries Ovary - drug effects Ovary - metabolism Patients Plants Polycystic ovary syndrome Polycystic Ovary Syndrome - drug therapy Protein biosynthesis Proteins Proteolysis Proteomics Rats Rats, Sprague-Dawley Rodents Signs and symptoms Synthesis Testosterone Vector-borne diseases Young Adult
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