A small-molecule degron with a phenylpropionic acid scaffold

[Display omitted] Targeted protein degradation (TPD), employing proteolysis-targeting chimeras (PROTACs) composed of ligands for both a target protein and ubiquitin ligase (E3) to redirect the ubiquitin–proteasome system (UPS) to the target protein, has emerged as a promising strategy in drug discov...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2024-07, Vol.109, p.117789, Article 117789
Hauptverfasser:	Tomoshige, Shusuke, Komatsu, Fumiko, Kikuchi, Tomoko, Sugiyama, Miku, Kawasaki, Yushi, Ohgane, Kenji, Furuyama, Yuuki, Sato, Shinichi, Ishikawa, Minoru, Kuramochi, Kouji
Format:	Artikel
Sprache:	eng
Schlagworte:	Phenylpropionic acid Small-molecule degron Targeted protein degradation
Online-Zugang:	Volltext
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