Joint association of drinking alcohol and obesity in relation to cancer risk: A systematic review and data synthesis
Rates of alcohol consumption and obesity are increasing in many Western populations. For some cancer types, both heavy alcohol consumption and obesity are independently associated with increased risk. Whether combined exposure to both synergistically increases an individual's risk of cancer is...
Gespeichert in:
| Veröffentlicht in: | Cancer epidemiology 2024-08, Vol.91, p.102596, Article 102596 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | 102596 |
| container_title | Cancer epidemiology |
| container_volume | 91 |
| creator | Macdonald, Graeme A. Thomas, James A. Dalais, Christine Kendall, Bradley J. Thrift, Aaron P. |
| description | Rates of alcohol consumption and obesity are increasing in many Western populations. For some cancer types, both heavy alcohol consumption and obesity are independently associated with increased risk. Whether combined exposure to both synergistically increases an individual's risk of cancer is unclear. We performed a systematic review to assess whether alcohol and obesity interact to confer higher risk for cancer than the additive sum of their effects.
A systematic literature search was conducted from the inception date to 13 February 2024 of PubMed, Embase, Cochrane Library and Web of Science to identify studies of alcohol, obesity, and cancer risk. We aimed to undertake a meta-analysis if there were sufficient data.
The literature search identified 17,740 potentially eligible studies. After review, 24 studies were included. Eleven reported on the association between alcohol consumption and cancer risk in individuals according to their body mass index (BMI), nine reported on the association between BMI and cancer risk in individuals according to their alcohol consumption, and six studies examined potential synergistic interactions between alcohol consumption and obesity on cancer risk. However, there were insufficient data and significant heterogeneity in the cancers studied to undertake meta-analysis, therefore a systemic review and narrative synthesis was conducted. Overall, there was no consistent pattern of interaction between alcohol use and overweight/obesity on cancer risk across cancer types.
While alcohol and obesity are prevalent and important risk factors for a range of cancers, data are lacking on whether their combined exposure may synergistically increase an individual's risk for cancer. Further study across more cancer types is required to better understand the nature of interactions between alcohol use and obesity on cancer risk.
•Alcohol use and obesity are recognized independent cancer risk factors.•Few studies have examined interactions between drinking alcohol and obesity.•There was no consistent pattern of interaction on cancer risk across cancer types.•There was heterogeneity of studies in modeling alcohol use and obesity.•Further research is needed to clarify potential additive associations with cancer. |
| doi_str_mv | 10.1016/j.canep.2024.102596 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3068752771</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1877782124000754</els_id><sourcerecordid>3079804716</sourcerecordid><originalsourceid>FETCH-LOGICAL-c267t-d60d871345f936df17dbd4aa8febddce1bab99de56a79b3a0246dc0373bf1ced3</originalsourceid><addsrcrecordid>eNp9kU9PGzEQxS1UxJ-UT1CpstQLlwR7nbV3K_UQIWiLInGhEjfLa88Wh42d2g5Vvj1DlnLogZNHnt-bGb1HyCfOZpxxebGaWRNgM6tYNcefqm7lATnhjVJT1Yj7D291xY_Jac4rxqTkvD4ix6JpFJOVOCHlJvpQqMk5Wm-Kj4HGnrrkw6MPv6kZbHyIAzXB0dhB9mVHfaAJhpEtkeIRFhJNPj9-pQuad7nAGrsWqScPf_daZ4rBVigPOCN_JIe9GTKcvb4T8uv66u7yx3R5-_3n5WI5tZVUZeokc43iYl73rZCu58p1bm5M00PnnAXema5tHdTSqLYTBn2QzjKhRNdzC05MyPk4d5Piny3kotc-WxgG9C1usxZMNqquFO6YkC__oau4TQGvQ0q1DZsrLpESI2VTzDlBrzfJr03aac70Syh6pfeh6JdQ9BgKqj6_zt52a3Bvmn8pIPBtBADNQM-SztYD2up8Alu0i_7dBc_ql6B3</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3079804716</pqid></control><display><type>article</type><title>Joint association of drinking alcohol and obesity in relation to cancer risk: A systematic review and data synthesis</title><source>Access via ScienceDirect (Elsevier)</source><source>ProQuest Central UK/Ireland</source><creator>Macdonald, Graeme A. ; Thomas, James A. ; Dalais, Christine ; Kendall, Bradley J. ; Thrift, Aaron P.</creator><creatorcontrib>Macdonald, Graeme A. ; Thomas, James A. ; Dalais, Christine ; Kendall, Bradley J. ; Thrift, Aaron P.</creatorcontrib><description>Rates of alcohol consumption and obesity are increasing in many Western populations. For some cancer types, both heavy alcohol consumption and obesity are independently associated with increased risk. Whether combined exposure to both synergistically increases an individual's risk of cancer is unclear. We performed a systematic review to assess whether alcohol and obesity interact to confer higher risk for cancer than the additive sum of their effects.
A systematic literature search was conducted from the inception date to 13 February 2024 of PubMed, Embase, Cochrane Library and Web of Science to identify studies of alcohol, obesity, and cancer risk. We aimed to undertake a meta-analysis if there were sufficient data.
The literature search identified 17,740 potentially eligible studies. After review, 24 studies were included. Eleven reported on the association between alcohol consumption and cancer risk in individuals according to their body mass index (BMI), nine reported on the association between BMI and cancer risk in individuals according to their alcohol consumption, and six studies examined potential synergistic interactions between alcohol consumption and obesity on cancer risk. However, there were insufficient data and significant heterogeneity in the cancers studied to undertake meta-analysis, therefore a systemic review and narrative synthesis was conducted. Overall, there was no consistent pattern of interaction between alcohol use and overweight/obesity on cancer risk across cancer types.
While alcohol and obesity are prevalent and important risk factors for a range of cancers, data are lacking on whether their combined exposure may synergistically increase an individual's risk for cancer. Further study across more cancer types is required to better understand the nature of interactions between alcohol use and obesity on cancer risk.
•Alcohol use and obesity are recognized independent cancer risk factors.•Few studies have examined interactions between drinking alcohol and obesity.•There was no consistent pattern of interaction on cancer risk across cancer types.•There was heterogeneity of studies in modeling alcohol use and obesity.•Further research is needed to clarify potential additive associations with cancer.</description><identifier>ISSN: 1877-7821</identifier><identifier>ISSN: 1877-783X</identifier><identifier>EISSN: 1877-783X</identifier><identifier>DOI: 10.1016/j.canep.2024.102596</identifier><identifier>PMID: 38870623</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adiposity ; Alcohol ; Alcohol use ; Alcoholic beverages ; Alcohols ; Body mass index ; Body size ; Breast cancer ; Cancer ; Cancer risk ; Carcinogens ; Cohort analysis ; Data analysis ; Drinking behavior ; Health risks ; Heterogeneity ; Interaction ; Literature reviews ; Meta-analysis ; Obesity ; Observational studies ; Overweight ; Oxidative stress ; Pancreatic cancer ; Pattern analysis ; Public health ; Reviews ; Risk analysis ; Risk factors ; Synthesis ; Systematic review ; Womens health</subject><ispartof>Cancer epidemiology, 2024-08, Vol.91, p.102596, Article 102596</ispartof><rights>2024 Elsevier Ltd</rights><rights>Copyright © 2024 Elsevier Ltd. All rights reserved.</rights><rights>2024. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c267t-d60d871345f936df17dbd4aa8febddce1bab99de56a79b3a0246dc0373bf1ced3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/3079804716?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38870623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Macdonald, Graeme A.</creatorcontrib><creatorcontrib>Thomas, James A.</creatorcontrib><creatorcontrib>Dalais, Christine</creatorcontrib><creatorcontrib>Kendall, Bradley J.</creatorcontrib><creatorcontrib>Thrift, Aaron P.</creatorcontrib><title>Joint association of drinking alcohol and obesity in relation to cancer risk: A systematic review and data synthesis</title><title>Cancer epidemiology</title><addtitle>Cancer Epidemiol</addtitle><description>Rates of alcohol consumption and obesity are increasing in many Western populations. For some cancer types, both heavy alcohol consumption and obesity are independently associated with increased risk. Whether combined exposure to both synergistically increases an individual's risk of cancer is unclear. We performed a systematic review to assess whether alcohol and obesity interact to confer higher risk for cancer than the additive sum of their effects.
A systematic literature search was conducted from the inception date to 13 February 2024 of PubMed, Embase, Cochrane Library and Web of Science to identify studies of alcohol, obesity, and cancer risk. We aimed to undertake a meta-analysis if there were sufficient data.
The literature search identified 17,740 potentially eligible studies. After review, 24 studies were included. Eleven reported on the association between alcohol consumption and cancer risk in individuals according to their body mass index (BMI), nine reported on the association between BMI and cancer risk in individuals according to their alcohol consumption, and six studies examined potential synergistic interactions between alcohol consumption and obesity on cancer risk. However, there were insufficient data and significant heterogeneity in the cancers studied to undertake meta-analysis, therefore a systemic review and narrative synthesis was conducted. Overall, there was no consistent pattern of interaction between alcohol use and overweight/obesity on cancer risk across cancer types.
While alcohol and obesity are prevalent and important risk factors for a range of cancers, data are lacking on whether their combined exposure may synergistically increase an individual's risk for cancer. Further study across more cancer types is required to better understand the nature of interactions between alcohol use and obesity on cancer risk.
•Alcohol use and obesity are recognized independent cancer risk factors.•Few studies have examined interactions between drinking alcohol and obesity.•There was no consistent pattern of interaction on cancer risk across cancer types.•There was heterogeneity of studies in modeling alcohol use and obesity.•Further research is needed to clarify potential additive associations with cancer.</description><subject>Adiposity</subject><subject>Alcohol</subject><subject>Alcohol use</subject><subject>Alcoholic beverages</subject><subject>Alcohols</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer risk</subject><subject>Carcinogens</subject><subject>Cohort analysis</subject><subject>Data analysis</subject><subject>Drinking behavior</subject><subject>Health risks</subject><subject>Heterogeneity</subject><subject>Interaction</subject><subject>Literature reviews</subject><subject>Meta-analysis</subject><subject>Obesity</subject><subject>Observational studies</subject><subject>Overweight</subject><subject>Oxidative stress</subject><subject>Pancreatic cancer</subject><subject>Pattern analysis</subject><subject>Public health</subject><subject>Reviews</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Synthesis</subject><subject>Systematic review</subject><subject>Womens health</subject><issn>1877-7821</issn><issn>1877-783X</issn><issn>1877-783X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU9PGzEQxS1UxJ-UT1CpstQLlwR7nbV3K_UQIWiLInGhEjfLa88Wh42d2g5Vvj1DlnLogZNHnt-bGb1HyCfOZpxxebGaWRNgM6tYNcefqm7lATnhjVJT1Yj7D291xY_Jac4rxqTkvD4ix6JpFJOVOCHlJvpQqMk5Wm-Kj4HGnrrkw6MPv6kZbHyIAzXB0dhB9mVHfaAJhpEtkeIRFhJNPj9-pQuad7nAGrsWqScPf_daZ4rBVigPOCN_JIe9GTKcvb4T8uv66u7yx3R5-_3n5WI5tZVUZeokc43iYl73rZCu58p1bm5M00PnnAXema5tHdTSqLYTBn2QzjKhRNdzC05MyPk4d5Piny3kotc-WxgG9C1usxZMNqquFO6YkC__oau4TQGvQ0q1DZsrLpESI2VTzDlBrzfJr03aac70Syh6pfeh6JdQ9BgKqj6_zt52a3Bvmn8pIPBtBADNQM-SztYD2up8Alu0i_7dBc_ql6B3</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Macdonald, Graeme A.</creator><creator>Thomas, James A.</creator><creator>Dalais, Christine</creator><creator>Kendall, Bradley J.</creator><creator>Thrift, Aaron P.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20240801</creationdate><title>Joint association of drinking alcohol and obesity in relation to cancer risk: A systematic review and data synthesis</title><author>Macdonald, Graeme A. ; Thomas, James A. ; Dalais, Christine ; Kendall, Bradley J. ; Thrift, Aaron P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c267t-d60d871345f936df17dbd4aa8febddce1bab99de56a79b3a0246dc0373bf1ced3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adiposity</topic><topic>Alcohol</topic><topic>Alcohol use</topic><topic>Alcoholic beverages</topic><topic>Alcohols</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cancer risk</topic><topic>Carcinogens</topic><topic>Cohort analysis</topic><topic>Data analysis</topic><topic>Drinking behavior</topic><topic>Health risks</topic><topic>Heterogeneity</topic><topic>Interaction</topic><topic>Literature reviews</topic><topic>Meta-analysis</topic><topic>Obesity</topic><topic>Observational studies</topic><topic>Overweight</topic><topic>Oxidative stress</topic><topic>Pancreatic cancer</topic><topic>Pattern analysis</topic><topic>Public health</topic><topic>Reviews</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Synthesis</topic><topic>Systematic review</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Macdonald, Graeme A.</creatorcontrib><creatorcontrib>Thomas, James A.</creatorcontrib><creatorcontrib>Dalais, Christine</creatorcontrib><creatorcontrib>Kendall, Bradley J.</creatorcontrib><creatorcontrib>Thrift, Aaron P.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Macdonald, Graeme A.</au><au>Thomas, James A.</au><au>Dalais, Christine</au><au>Kendall, Bradley J.</au><au>Thrift, Aaron P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Joint association of drinking alcohol and obesity in relation to cancer risk: A systematic review and data synthesis</atitle><jtitle>Cancer epidemiology</jtitle><addtitle>Cancer Epidemiol</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>91</volume><spage>102596</spage><pages>102596-</pages><artnum>102596</artnum><issn>1877-7821</issn><issn>1877-783X</issn><eissn>1877-783X</eissn><abstract>Rates of alcohol consumption and obesity are increasing in many Western populations. For some cancer types, both heavy alcohol consumption and obesity are independently associated with increased risk. Whether combined exposure to both synergistically increases an individual's risk of cancer is unclear. We performed a systematic review to assess whether alcohol and obesity interact to confer higher risk for cancer than the additive sum of their effects.
A systematic literature search was conducted from the inception date to 13 February 2024 of PubMed, Embase, Cochrane Library and Web of Science to identify studies of alcohol, obesity, and cancer risk. We aimed to undertake a meta-analysis if there were sufficient data.
The literature search identified 17,740 potentially eligible studies. After review, 24 studies were included. Eleven reported on the association between alcohol consumption and cancer risk in individuals according to their body mass index (BMI), nine reported on the association between BMI and cancer risk in individuals according to their alcohol consumption, and six studies examined potential synergistic interactions between alcohol consumption and obesity on cancer risk. However, there were insufficient data and significant heterogeneity in the cancers studied to undertake meta-analysis, therefore a systemic review and narrative synthesis was conducted. Overall, there was no consistent pattern of interaction between alcohol use and overweight/obesity on cancer risk across cancer types.
While alcohol and obesity are prevalent and important risk factors for a range of cancers, data are lacking on whether their combined exposure may synergistically increase an individual's risk for cancer. Further study across more cancer types is required to better understand the nature of interactions between alcohol use and obesity on cancer risk.
•Alcohol use and obesity are recognized independent cancer risk factors.•Few studies have examined interactions between drinking alcohol and obesity.•There was no consistent pattern of interaction on cancer risk across cancer types.•There was heterogeneity of studies in modeling alcohol use and obesity.•Further research is needed to clarify potential additive associations with cancer.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>38870623</pmid><doi>10.1016/j.canep.2024.102596</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1877-7821 |
| ispartof | Cancer epidemiology, 2024-08, Vol.91, p.102596, Article 102596 |
| issn | 1877-7821 1877-783X 1877-783X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3068752771 |
| source | Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Adiposity Alcohol Alcohol use Alcoholic beverages Alcohols Body mass index Body size Breast cancer Cancer Cancer risk Carcinogens Cohort analysis Data analysis Drinking behavior Health risks Heterogeneity Interaction Literature reviews Meta-analysis Obesity Observational studies Overweight Oxidative stress Pancreatic cancer Pattern analysis Public health Reviews Risk analysis Risk factors Synthesis Systematic review Womens health |
| title | Joint association of drinking alcohol and obesity in relation to cancer risk: A systematic review and data synthesis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T23%3A16%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Joint%20association%20of%20drinking%20alcohol%20and%20obesity%20in%20relation%20to%20cancer%20risk:%20A%20systematic%20review%20and%20data%20synthesis&rft.jtitle=Cancer%20epidemiology&rft.au=Macdonald,%20Graeme%20A.&rft.date=2024-08-01&rft.volume=91&rft.spage=102596&rft.pages=102596-&rft.artnum=102596&rft.issn=1877-7821&rft.eissn=1877-783X&rft_id=info:doi/10.1016/j.canep.2024.102596&rft_dat=%3Cproquest_cross%3E3079804716%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3079804716&rft_id=info:pmid/38870623&rft_els_id=S1877782124000754&rfr_iscdi=true |