Iterative Design Reveals Molecular Domain Relationships in Supramolecular Peptide–Drug Conjugates

Supramolecular peptide–drug conjugates (sPDCs) are prepared by covalent attachment of a drug moiety to a peptide motif programmed for one-dimensional self-assembly, with subsequent physical entanglement of these fibrillar structures enabling formation of nanofibrous hydrogels. This class of prodrug...

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Veröffentlicht in:	Biomacromolecules 2024-07, Vol.25 (7), p.4482-4491
Hauptverfasser:	Sis, Matthew J., Liu, Dongping, Allen, Isabella, Webber, Matthew J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Design Drug Liberation Hydrogels - chemistry Hydrophobic and Hydrophilic Interactions Peptides - chemistry Prodrugs - chemistry
Online-Zugang:	Volltext
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