Retinal vessel density and choroidal flow changes in oligoarticular juvenile idiopathic arthritis with and without uveitis
Purpose This cross-sectional optical coherence tomography angiography (OCTA) study aimed to assess the macular and optic nerve head (ONH) vascular density, foveal avascular zone, and outer retina and choriocapillaris flow in oligoarticular juvenile idiopathic arthritis (oJIA). Study design Prospecti...
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| Veröffentlicht in: | Japanese journal of ophthalmology 2024-07, Vol.68 (4), p.327-337 |
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| creator | Yılmaz Tuğan, Büşra Sönmez, Hafize Emine Şahin, Nihal Bayrak, Yunus Emre Yüksel, Nurşen Karabaş, Levent |
| description | Purpose
This cross-sectional optical coherence tomography angiography (OCTA) study aimed to assess the macular and optic nerve head (ONH) vascular density, foveal avascular zone, and outer retina and choriocapillaris flow in oligoarticular juvenile idiopathic arthritis (oJIA).
Study design
Prospective.
Methods
Twenty-two eyes of 22 oJIA patients with uveitis (oJIA-U), 20 eyes of 20 oJIA patients without uveitis (isolated oJIA), and 26 healthy volunteers of similar ages and sexes were investigated. The superficial capillary plexus (SCP) and deep capillary plexus (DCP), ONH, foveal avascular zone (FAZ) parameters, the flow area of the outer retina, and choriocapillaris were evaluated.
Results
Compared with the control group, both the oJIA-U group and isolated oJIA group showed significantly decreased vessel density of parafovea (
p
= 0.031 and
p
= 0.047, respectively) in DCP. Choriocapillaris flow area at 1 mm radius was significantly lower in the oJIA-U group compared to the control group (
p
= 0.001). Choriocapillaris flow area at 2- and 3-mm radius were significantly lower in the oJIA-U group compared to the control group (
p
|
| doi_str_mv | 10.1007/s10384-024-01074-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3068750832</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3097828024</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-95f5958757d725b6c82b6e60ea7730ac33f56646ede696f133bf8183ec3dcc513</originalsourceid><addsrcrecordid>eNp9kUtrGzEUhUVoSNy0f6CLIOimm2n0GD28LCFNCoZASNZC1tyxZeSRK2likl9fTZwm0EUXQhLn07noHIS-UPKdEqIuMiVctw1hdVGi2oYdoRmVlDeMtfIDmhHCaCOoEKfoY84bQkjLODtBp1xr1UrZztDzHRQ_2IAfIWcIuIMh-_KE7dBht44p-q6KfYj7erXDCjL2A47Br6JNxbsx2IQ34yMMPgD2nY87W9be4aquky8-470v6xe_6RDHgis9CZ_QcW9Dhs-v-xl6-Hl1f3nTLG6vf13-WDSOM1mauejFXGglVKeYWEqn2VKCJGCV4sQ6zntRvyKhAzmXPeV82WuqOTjeOScoP0PfDr67FH-PkIvZ-uwgBDtAHLPhRFZ3ojmr6Nd_0E0cU41nouZKM13DrhQ7UC7FnBP0Zpf81qYnQ4mZmjGHZkyFzUszZrI-f7Uel1vo3p78raIC_ADkKtWg0_vs_9j-AeoemtM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3097828024</pqid></control><display><type>article</type><title>Retinal vessel density and choroidal flow changes in oligoarticular juvenile idiopathic arthritis with and without uveitis</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Yılmaz Tuğan, Büşra ; Sönmez, Hafize Emine ; Şahin, Nihal ; Bayrak, Yunus Emre ; Yüksel, Nurşen ; Karabaş, Levent</creator><creatorcontrib>Yılmaz Tuğan, Büşra ; Sönmez, Hafize Emine ; Şahin, Nihal ; Bayrak, Yunus Emre ; Yüksel, Nurşen ; Karabaş, Levent</creatorcontrib><description>Purpose
This cross-sectional optical coherence tomography angiography (OCTA) study aimed to assess the macular and optic nerve head (ONH) vascular density, foveal avascular zone, and outer retina and choriocapillaris flow in oligoarticular juvenile idiopathic arthritis (oJIA).
Study design
Prospective.
Methods
Twenty-two eyes of 22 oJIA patients with uveitis (oJIA-U), 20 eyes of 20 oJIA patients without uveitis (isolated oJIA), and 26 healthy volunteers of similar ages and sexes were investigated. The superficial capillary plexus (SCP) and deep capillary plexus (DCP), ONH, foveal avascular zone (FAZ) parameters, the flow area of the outer retina, and choriocapillaris were evaluated.
Results
Compared with the control group, both the oJIA-U group and isolated oJIA group showed significantly decreased vessel density of parafovea (
p
= 0.031 and
p
= 0.047, respectively) in DCP. Choriocapillaris flow area at 1 mm radius was significantly lower in the oJIA-U group compared to the control group (
p
= 0.001). Choriocapillaris flow area at 2- and 3-mm radius were significantly lower in the oJIA-U group compared to the control group (
p
< 0.001, for both) and isolated oJIA-U group compared to the control group (
p
= 0.008 and
p
= 0.001, respectively). The VD and thickness parameters of SCP and ONH, FAZ, and outer retina flow area were similar between the groups.
Conclusions
oJIA patients with and without uveitis revealed a decreased vessel density in the deep parafoveal region and choriocapillaris flow. Our findings suggest that retinal choroidal microvascular changes could be evident in oJIA-U patients without posterior segment involvement as well as oJIA patients without uveitis.</description><identifier>ISSN: 0021-5155</identifier><identifier>ISSN: 1613-2246</identifier><identifier>EISSN: 1613-2246</identifier><identifier>DOI: 10.1007/s10384-024-01074-2</identifier><identifier>PMID: 38874664</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adolescent ; Adult ; Angiography ; Arthritis ; Arthritis, Juvenile - complications ; Arthritis, Juvenile - physiopathology ; Blood vessels ; Child ; Choroid - blood supply ; Choroid - diagnostic imaging ; Clinical Investigation ; Cross-Sectional Studies ; Density ; Eye (anatomy) ; Female ; Fluorescein Angiography - methods ; Fundus Oculi ; Humans ; Male ; Medicine ; Medicine & Public Health ; Microvasculature ; Ophthalmology ; Optic Disk - blood supply ; Optic nerve ; Parameters ; Prospective Studies ; Regional Blood Flow - physiology ; Retina ; Retinal Vessels - diagnostic imaging ; Retinal Vessels - pathology ; Retinal Vessels - physiopathology ; Tomography, Optical Coherence - methods ; Uveitis ; Uveitis - diagnosis ; Uveitis - physiopathology ; Visual Acuity - physiology ; Young Adult</subject><ispartof>Japanese journal of ophthalmology, 2024-07, Vol.68 (4), p.327-337</ispartof><rights>Japanese Ophthalmological Society 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. Japanese Ophthalmological Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-95f5958757d725b6c82b6e60ea7730ac33f56646ede696f133bf8183ec3dcc513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10384-024-01074-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10384-024-01074-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27906,27907,41470,42539,51301</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38874664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yılmaz Tuğan, Büşra</creatorcontrib><creatorcontrib>Sönmez, Hafize Emine</creatorcontrib><creatorcontrib>Şahin, Nihal</creatorcontrib><creatorcontrib>Bayrak, Yunus Emre</creatorcontrib><creatorcontrib>Yüksel, Nurşen</creatorcontrib><creatorcontrib>Karabaş, Levent</creatorcontrib><title>Retinal vessel density and choroidal flow changes in oligoarticular juvenile idiopathic arthritis with and without uveitis</title><title>Japanese journal of ophthalmology</title><addtitle>Jpn J Ophthalmol</addtitle><addtitle>Jpn J Ophthalmol</addtitle><description>Purpose
This cross-sectional optical coherence tomography angiography (OCTA) study aimed to assess the macular and optic nerve head (ONH) vascular density, foveal avascular zone, and outer retina and choriocapillaris flow in oligoarticular juvenile idiopathic arthritis (oJIA).
Study design
Prospective.
Methods
Twenty-two eyes of 22 oJIA patients with uveitis (oJIA-U), 20 eyes of 20 oJIA patients without uveitis (isolated oJIA), and 26 healthy volunteers of similar ages and sexes were investigated. The superficial capillary plexus (SCP) and deep capillary plexus (DCP), ONH, foveal avascular zone (FAZ) parameters, the flow area of the outer retina, and choriocapillaris were evaluated.
Results
Compared with the control group, both the oJIA-U group and isolated oJIA group showed significantly decreased vessel density of parafovea (
p
= 0.031 and
p
= 0.047, respectively) in DCP. Choriocapillaris flow area at 1 mm radius was significantly lower in the oJIA-U group compared to the control group (
p
= 0.001). Choriocapillaris flow area at 2- and 3-mm radius were significantly lower in the oJIA-U group compared to the control group (
p
< 0.001, for both) and isolated oJIA-U group compared to the control group (
p
= 0.008 and
p
= 0.001, respectively). The VD and thickness parameters of SCP and ONH, FAZ, and outer retina flow area were similar between the groups.
Conclusions
oJIA patients with and without uveitis revealed a decreased vessel density in the deep parafoveal region and choriocapillaris flow. Our findings suggest that retinal choroidal microvascular changes could be evident in oJIA-U patients without posterior segment involvement as well as oJIA patients without uveitis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Angiography</subject><subject>Arthritis</subject><subject>Arthritis, Juvenile - complications</subject><subject>Arthritis, Juvenile - physiopathology</subject><subject>Blood vessels</subject><subject>Child</subject><subject>Choroid - blood supply</subject><subject>Choroid - diagnostic imaging</subject><subject>Clinical Investigation</subject><subject>Cross-Sectional Studies</subject><subject>Density</subject><subject>Eye (anatomy)</subject><subject>Female</subject><subject>Fluorescein Angiography - methods</subject><subject>Fundus Oculi</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microvasculature</subject><subject>Ophthalmology</subject><subject>Optic Disk - blood supply</subject><subject>Optic nerve</subject><subject>Parameters</subject><subject>Prospective Studies</subject><subject>Regional Blood Flow - physiology</subject><subject>Retina</subject><subject>Retinal Vessels - diagnostic imaging</subject><subject>Retinal Vessels - pathology</subject><subject>Retinal Vessels - physiopathology</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Uveitis</subject><subject>Uveitis - diagnosis</subject><subject>Uveitis - physiopathology</subject><subject>Visual Acuity - physiology</subject><subject>Young Adult</subject><issn>0021-5155</issn><issn>1613-2246</issn><issn>1613-2246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtrGzEUhUVoSNy0f6CLIOimm2n0GD28LCFNCoZASNZC1tyxZeSRK2likl9fTZwm0EUXQhLn07noHIS-UPKdEqIuMiVctw1hdVGi2oYdoRmVlDeMtfIDmhHCaCOoEKfoY84bQkjLODtBp1xr1UrZztDzHRQ_2IAfIWcIuIMh-_KE7dBht44p-q6KfYj7erXDCjL2A47Br6JNxbsx2IQ34yMMPgD2nY87W9be4aquky8-470v6xe_6RDHgis9CZ_QcW9Dhs-v-xl6-Hl1f3nTLG6vf13-WDSOM1mauejFXGglVKeYWEqn2VKCJGCV4sQ6zntRvyKhAzmXPeV82WuqOTjeOScoP0PfDr67FH-PkIvZ-uwgBDtAHLPhRFZ3ojmr6Nd_0E0cU41nouZKM13DrhQ7UC7FnBP0Zpf81qYnQ4mZmjGHZkyFzUszZrI-f7Uel1vo3p78raIC_ADkKtWg0_vs_9j-AeoemtM</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Yılmaz Tuğan, Büşra</creator><creator>Sönmez, Hafize Emine</creator><creator>Şahin, Nihal</creator><creator>Bayrak, Yunus Emre</creator><creator>Yüksel, Nurşen</creator><creator>Karabaş, Levent</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20240701</creationdate><title>Retinal vessel density and choroidal flow changes in oligoarticular juvenile idiopathic arthritis with and without uveitis</title><author>Yılmaz Tuğan, Büşra ; Sönmez, Hafize Emine ; Şahin, Nihal ; Bayrak, Yunus Emre ; Yüksel, Nurşen ; Karabaş, Levent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-95f5958757d725b6c82b6e60ea7730ac33f56646ede696f133bf8183ec3dcc513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Angiography</topic><topic>Arthritis</topic><topic>Arthritis, Juvenile - complications</topic><topic>Arthritis, Juvenile - physiopathology</topic><topic>Blood vessels</topic><topic>Child</topic><topic>Choroid - blood supply</topic><topic>Choroid - diagnostic imaging</topic><topic>Clinical Investigation</topic><topic>Cross-Sectional Studies</topic><topic>Density</topic><topic>Eye (anatomy)</topic><topic>Female</topic><topic>Fluorescein Angiography - methods</topic><topic>Fundus Oculi</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microvasculature</topic><topic>Ophthalmology</topic><topic>Optic Disk - blood supply</topic><topic>Optic nerve</topic><topic>Parameters</topic><topic>Prospective Studies</topic><topic>Regional Blood Flow - physiology</topic><topic>Retina</topic><topic>Retinal Vessels - diagnostic imaging</topic><topic>Retinal Vessels - pathology</topic><topic>Retinal Vessels - physiopathology</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Uveitis</topic><topic>Uveitis - diagnosis</topic><topic>Uveitis - physiopathology</topic><topic>Visual Acuity - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yılmaz Tuğan, Büşra</creatorcontrib><creatorcontrib>Sönmez, Hafize Emine</creatorcontrib><creatorcontrib>Şahin, Nihal</creatorcontrib><creatorcontrib>Bayrak, Yunus Emre</creatorcontrib><creatorcontrib>Yüksel, Nurşen</creatorcontrib><creatorcontrib>Karabaş, Levent</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yılmaz Tuğan, Büşra</au><au>Sönmez, Hafize Emine</au><au>Şahin, Nihal</au><au>Bayrak, Yunus Emre</au><au>Yüksel, Nurşen</au><au>Karabaş, Levent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinal vessel density and choroidal flow changes in oligoarticular juvenile idiopathic arthritis with and without uveitis</atitle><jtitle>Japanese journal of ophthalmology</jtitle><stitle>Jpn J Ophthalmol</stitle><addtitle>Jpn J Ophthalmol</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>68</volume><issue>4</issue><spage>327</spage><epage>337</epage><pages>327-337</pages><issn>0021-5155</issn><issn>1613-2246</issn><eissn>1613-2246</eissn><abstract>Purpose
This cross-sectional optical coherence tomography angiography (OCTA) study aimed to assess the macular and optic nerve head (ONH) vascular density, foveal avascular zone, and outer retina and choriocapillaris flow in oligoarticular juvenile idiopathic arthritis (oJIA).
Study design
Prospective.
Methods
Twenty-two eyes of 22 oJIA patients with uveitis (oJIA-U), 20 eyes of 20 oJIA patients without uveitis (isolated oJIA), and 26 healthy volunteers of similar ages and sexes were investigated. The superficial capillary plexus (SCP) and deep capillary plexus (DCP), ONH, foveal avascular zone (FAZ) parameters, the flow area of the outer retina, and choriocapillaris were evaluated.
Results
Compared with the control group, both the oJIA-U group and isolated oJIA group showed significantly decreased vessel density of parafovea (
p
= 0.031 and
p
= 0.047, respectively) in DCP. Choriocapillaris flow area at 1 mm radius was significantly lower in the oJIA-U group compared to the control group (
p
= 0.001). Choriocapillaris flow area at 2- and 3-mm radius were significantly lower in the oJIA-U group compared to the control group (
p
< 0.001, for both) and isolated oJIA-U group compared to the control group (
p
= 0.008 and
p
= 0.001, respectively). The VD and thickness parameters of SCP and ONH, FAZ, and outer retina flow area were similar between the groups.
Conclusions
oJIA patients with and without uveitis revealed a decreased vessel density in the deep parafoveal region and choriocapillaris flow. Our findings suggest that retinal choroidal microvascular changes could be evident in oJIA-U patients without posterior segment involvement as well as oJIA patients without uveitis.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>38874664</pmid><doi>10.1007/s10384-024-01074-2</doi><tpages>11</tpages></addata></record> |
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| ispartof | Japanese journal of ophthalmology, 2024-07, Vol.68 (4), p.327-337 |
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| language | eng |
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| subjects | Adolescent Adult Angiography Arthritis Arthritis, Juvenile - complications Arthritis, Juvenile - physiopathology Blood vessels Child Choroid - blood supply Choroid - diagnostic imaging Clinical Investigation Cross-Sectional Studies Density Eye (anatomy) Female Fluorescein Angiography - methods Fundus Oculi Humans Male Medicine Medicine & Public Health Microvasculature Ophthalmology Optic Disk - blood supply Optic nerve Parameters Prospective Studies Regional Blood Flow - physiology Retina Retinal Vessels - diagnostic imaging Retinal Vessels - pathology Retinal Vessels - physiopathology Tomography, Optical Coherence - methods Uveitis Uveitis - diagnosis Uveitis - physiopathology Visual Acuity - physiology Young Adult |
| title | Retinal vessel density and choroidal flow changes in oligoarticular juvenile idiopathic arthritis with and without uveitis |
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