Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer

Non-small-cell lung cancer (NSCLC) with concurrent mutations in KRAS and the tumour suppressor LKB1 (KL NSCLC) is refractory to most therapies and has one of the worst predicted outcomes. Here we describe a KL-induced metabolic vulnerability associated with serine–glycine-one-carbon (SGOC) metabolis...

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Veröffentlicht in:	Nature metabolism 2024-07, Vol.6 (7), p.1310-1328
Hauptverfasser:	Lee, Hyun Min, Muhammad, Nefertiti, Lieu, Elizabeth L., Cai, Feng, Mu, Jiawei, Ha, Yun-Sok, Cao, Guoshen, Suchors, Chamey, Joves, Kenneth, Chronis, Constantinos, Li, Kailong, Ducker, Gregory S., Olszewski, Kellen, Cai, Ling, Allison, Derek B., Bachert, Sara E., Ewing, William R., Wong, Harvey, Seo, Hyosun, Kim, Isaac Y., Faubert, Brandon, Kim, James, Kim, Jiyeon
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/319 631/67/2327 631/80/86/2369 Biomedical and Life Sciences Life Sciences
Online-Zugang:	Volltext
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