The safety and efficacy outcomes of Minnelide given alone or in combination with paclitaxel in advanced gastric cancer: A phase I trial

Minnelide is a water-soluble disodium salt variant of triptolide, an HSP70 inhibitor that can prevent tumor progression and induce apoptosis. Maximum tolerated dose (MTD), safety, and antitumor activity of Minnelide alone and its combination with paclitaxel were evaluated in this open-label, single-...

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Veröffentlicht in:	Cancer letters 2024-08, Vol.597, p.217041, Article 217041
Hauptverfasser:	Lim, Sung Hee, Saluja, Ashok, Vickers, Selwyn, Hong, Jung Yong, Kim, Seung Tae, Lavania, Shweta, Pandey, Somnath, Gupta, Vineet K., Velagapudi, Mohana R., Lee, Jeeyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Diterpenes - administration & dosage Diterpenes - adverse effects Epoxy Compounds - administration & dosage Epoxy Compounds - adverse effects Female Gastric cancer Humans Male Maximum Tolerated Dose Middle Aged Minnelide Organophosphates Paclitaxel Paclitaxel - administration & dosage Paclitaxel - adverse effects Phenanthrenes - administration & dosage Phenanthrenes - adverse effects Phenanthrenes - therapeutic use Salvage treatment Stomach Neoplasms - drug therapy Stomach Neoplasms - pathology Treatment Outcome
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