Unraveling the miRNA Puzzle in Atherosclerosis: Revolutionizing Diagnosis, Prognosis, and Therapeutic Approaches
Purpose of Review To eradicate atherosclerotic diseases, novel biomarkers, and future therapy targets must reveal the burden of early atherosclerosis (AS), which occurs before life-threatening unstable plaques form. The chemical and biological features of microRNAs (miRNAs) make them interesting bio...
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| Veröffentlicht in: | Current atherosclerosis reports 2024-08, Vol.26 (8), p.395-410 |
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| creator | Abulsoud, Ahmed I. Elshaer, Shereen Saeid Rizk, Nehal I. Khaled, Reem Abdelfatah, Amr M. Aboelyazed, Ahmed M. Waseem, Aly M. Bashier, Doha Mohammed, Osama A. Elballal, Mohammed S. Mageed, Sherif S. Abdel Elrebehy, Mahmoud A. Zaki, Mohamed Bakr Elesawy, Ahmed E. El-Dakroury, Walaa A. Abdel-Reheim, Mustafa Ahmed Saber, Sameh Doghish, Ahmed S. |
| description | Purpose of Review
To eradicate atherosclerotic diseases, novel biomarkers, and future therapy targets must reveal the burden of early atherosclerosis (AS), which occurs before life-threatening unstable plaques form. The chemical and biological features of microRNAs (miRNAs) make them interesting biomarkers for numerous diseases. We summarized the latest research on miRNA regulatory mechanisms in AS progression studies, which may help us use miRNAs as biomarkers and treatments for difficult-to-treat diseases.
Recent Findings
Recent research has demonstrated that miRNAs have a regulatory function in the observed changes in gene and protein expression during atherogenesis, the process that leads to atherosclerosis. Several miRNAs play a role in the development of atherosclerosis, and these miRNAs could potentially serve as non-invasive biomarkers for atherosclerosis in various regions of the body. These miRNAs have the potential to serve as biomarkers and targets for early treatment of atherosclerosis.
Summary
The start and development of AS require different miRNAs. It reviews new research on miRNAs affecting endothelium, vascular smooth muscle, vascular inflammation, lipid retention, and cholesterol metabolism in AS. A miRNA gene expression profile circulates with AS everywhere. AS therapies include lipid metabolism, inflammation reduction, and oxidative stress inhibition. Clinical use of miRNAs requires tremendous progress. We think tiny miRNAs can enable personalized treatment. |
| doi_str_mv | 10.1007/s11883-024-01216-4 |
| format | Article |
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To eradicate atherosclerotic diseases, novel biomarkers, and future therapy targets must reveal the burden of early atherosclerosis (AS), which occurs before life-threatening unstable plaques form. The chemical and biological features of microRNAs (miRNAs) make them interesting biomarkers for numerous diseases. We summarized the latest research on miRNA regulatory mechanisms in AS progression studies, which may help us use miRNAs as biomarkers and treatments for difficult-to-treat diseases.
Recent Findings
Recent research has demonstrated that miRNAs have a regulatory function in the observed changes in gene and protein expression during atherogenesis, the process that leads to atherosclerosis. Several miRNAs play a role in the development of atherosclerosis, and these miRNAs could potentially serve as non-invasive biomarkers for atherosclerosis in various regions of the body. These miRNAs have the potential to serve as biomarkers and targets for early treatment of atherosclerosis.
Summary
The start and development of AS require different miRNAs. It reviews new research on miRNAs affecting endothelium, vascular smooth muscle, vascular inflammation, lipid retention, and cholesterol metabolism in AS. A miRNA gene expression profile circulates with AS everywhere. AS therapies include lipid metabolism, inflammation reduction, and oxidative stress inhibition. Clinical use of miRNAs requires tremendous progress. We think tiny miRNAs can enable personalized treatment.</description><identifier>ISSN: 1523-3804</identifier><identifier>ISSN: 1534-6242</identifier><identifier>EISSN: 1534-6242</identifier><identifier>DOI: 10.1007/s11883-024-01216-4</identifier><identifier>PMID: 38869707</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Angiology ; Animals ; Atherosclerosis - diagnosis ; Atherosclerosis - genetics ; Atherosclerosis - metabolism ; Atherosclerosis - therapy ; Biomarkers - metabolism ; Cardiology ; Humans ; Medicine ; Medicine & Public Health ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Prognosis ; Review ; Topical Collection on Vascular Biology</subject><ispartof>Current atherosclerosis reports, 2024-08, Vol.26 (8), p.395-410</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c298t-c4a6b24774b25abd139d6e91a3832e73e67345a583ecad83933106dcc4cf6b773</cites><orcidid>0000-0002-7728-0923 ; 0000-0002-0136-7096</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11883-024-01216-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11883-024-01216-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38869707$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abulsoud, Ahmed I.</creatorcontrib><creatorcontrib>Elshaer, Shereen Saeid</creatorcontrib><creatorcontrib>Rizk, Nehal I.</creatorcontrib><creatorcontrib>Khaled, Reem</creatorcontrib><creatorcontrib>Abdelfatah, Amr M.</creatorcontrib><creatorcontrib>Aboelyazed, Ahmed M.</creatorcontrib><creatorcontrib>Waseem, Aly M.</creatorcontrib><creatorcontrib>Bashier, Doha</creatorcontrib><creatorcontrib>Mohammed, Osama A.</creatorcontrib><creatorcontrib>Elballal, Mohammed S.</creatorcontrib><creatorcontrib>Mageed, Sherif S. Abdel</creatorcontrib><creatorcontrib>Elrebehy, Mahmoud A.</creatorcontrib><creatorcontrib>Zaki, Mohamed Bakr</creatorcontrib><creatorcontrib>Elesawy, Ahmed E.</creatorcontrib><creatorcontrib>El-Dakroury, Walaa A.</creatorcontrib><creatorcontrib>Abdel-Reheim, Mustafa Ahmed</creatorcontrib><creatorcontrib>Saber, Sameh</creatorcontrib><creatorcontrib>Doghish, Ahmed S.</creatorcontrib><title>Unraveling the miRNA Puzzle in Atherosclerosis: Revolutionizing Diagnosis, Prognosis, and Therapeutic Approaches</title><title>Current atherosclerosis reports</title><addtitle>Curr Atheroscler Rep</addtitle><addtitle>Curr Atheroscler Rep</addtitle><description>Purpose of Review
To eradicate atherosclerotic diseases, novel biomarkers, and future therapy targets must reveal the burden of early atherosclerosis (AS), which occurs before life-threatening unstable plaques form. The chemical and biological features of microRNAs (miRNAs) make them interesting biomarkers for numerous diseases. We summarized the latest research on miRNA regulatory mechanisms in AS progression studies, which may help us use miRNAs as biomarkers and treatments for difficult-to-treat diseases.
Recent Findings
Recent research has demonstrated that miRNAs have a regulatory function in the observed changes in gene and protein expression during atherogenesis, the process that leads to atherosclerosis. Several miRNAs play a role in the development of atherosclerosis, and these miRNAs could potentially serve as non-invasive biomarkers for atherosclerosis in various regions of the body. These miRNAs have the potential to serve as biomarkers and targets for early treatment of atherosclerosis.
Summary
The start and development of AS require different miRNAs. It reviews new research on miRNAs affecting endothelium, vascular smooth muscle, vascular inflammation, lipid retention, and cholesterol metabolism in AS. A miRNA gene expression profile circulates with AS everywhere. AS therapies include lipid metabolism, inflammation reduction, and oxidative stress inhibition. Clinical use of miRNAs requires tremendous progress. We think tiny miRNAs can enable personalized treatment.</description><subject>Angiology</subject><subject>Animals</subject><subject>Atherosclerosis - diagnosis</subject><subject>Atherosclerosis - genetics</subject><subject>Atherosclerosis - metabolism</subject><subject>Atherosclerosis - therapy</subject><subject>Biomarkers - metabolism</subject><subject>Cardiology</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Prognosis</subject><subject>Review</subject><subject>Topical Collection on Vascular Biology</subject><issn>1523-3804</issn><issn>1534-6242</issn><issn>1534-6242</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFP3DAQhS3UqlDaP8Ch8rEH0toex3Z6WwFtkRAgBGfLcWYXo6wT7A0S--vrdIEjl5mR571nzUfIEWc_OGP6Z-bcGKiYkBXjgqtK7pEDXoOslJDiwzwLqMAwuU8-5_zAmGBG8U9kH4xRjWb6gIx3Mbkn7ENc0c090nW4uVzQ62m77ZGGSBflMQ3Z93MN-Re9waehnzZhiGE7m06DW8V5dUyv0_A6utjR2-J0Ixatp4txTIPz95i_kI9L12f8-tIPyd3vs9uTv9XF1Z_zk8VF5UVjNpWXTrVCai1bUbu249B0ChvuwIBADag0yNrVBtC7zkADwJnqvJd-qVqt4ZB83-WWjx8nzBu7Dtlj37uIw5QtMKUbDjWIIhU7qS835oRLO6awdunZcmZn0nZH2hbS9j9pK4vp20v-1K6xe7O8oi0C2AlyWcUVJvswTCmWm9-L_Qfkc4qN</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Abulsoud, Ahmed I.</creator><creator>Elshaer, Shereen Saeid</creator><creator>Rizk, Nehal I.</creator><creator>Khaled, Reem</creator><creator>Abdelfatah, Amr M.</creator><creator>Aboelyazed, Ahmed M.</creator><creator>Waseem, Aly M.</creator><creator>Bashier, Doha</creator><creator>Mohammed, Osama A.</creator><creator>Elballal, Mohammed S.</creator><creator>Mageed, Sherif S. 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Abdel</creatorcontrib><creatorcontrib>Elrebehy, Mahmoud A.</creatorcontrib><creatorcontrib>Zaki, Mohamed Bakr</creatorcontrib><creatorcontrib>Elesawy, Ahmed E.</creatorcontrib><creatorcontrib>El-Dakroury, Walaa A.</creatorcontrib><creatorcontrib>Abdel-Reheim, Mustafa Ahmed</creatorcontrib><creatorcontrib>Saber, Sameh</creatorcontrib><creatorcontrib>Doghish, Ahmed S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current atherosclerosis reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abulsoud, Ahmed I.</au><au>Elshaer, Shereen Saeid</au><au>Rizk, Nehal I.</au><au>Khaled, Reem</au><au>Abdelfatah, Amr M.</au><au>Aboelyazed, Ahmed M.</au><au>Waseem, Aly M.</au><au>Bashier, Doha</au><au>Mohammed, Osama A.</au><au>Elballal, Mohammed S.</au><au>Mageed, Sherif S. Abdel</au><au>Elrebehy, Mahmoud A.</au><au>Zaki, Mohamed Bakr</au><au>Elesawy, Ahmed E.</au><au>El-Dakroury, Walaa A.</au><au>Abdel-Reheim, Mustafa Ahmed</au><au>Saber, Sameh</au><au>Doghish, Ahmed S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unraveling the miRNA Puzzle in Atherosclerosis: Revolutionizing Diagnosis, Prognosis, and Therapeutic Approaches</atitle><jtitle>Current atherosclerosis reports</jtitle><stitle>Curr Atheroscler Rep</stitle><addtitle>Curr Atheroscler Rep</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>26</volume><issue>8</issue><spage>395</spage><epage>410</epage><pages>395-410</pages><issn>1523-3804</issn><issn>1534-6242</issn><eissn>1534-6242</eissn><abstract>Purpose of Review
To eradicate atherosclerotic diseases, novel biomarkers, and future therapy targets must reveal the burden of early atherosclerosis (AS), which occurs before life-threatening unstable plaques form. The chemical and biological features of microRNAs (miRNAs) make them interesting biomarkers for numerous diseases. We summarized the latest research on miRNA regulatory mechanisms in AS progression studies, which may help us use miRNAs as biomarkers and treatments for difficult-to-treat diseases.
Recent Findings
Recent research has demonstrated that miRNAs have a regulatory function in the observed changes in gene and protein expression during atherogenesis, the process that leads to atherosclerosis. Several miRNAs play a role in the development of atherosclerosis, and these miRNAs could potentially serve as non-invasive biomarkers for atherosclerosis in various regions of the body. These miRNAs have the potential to serve as biomarkers and targets for early treatment of atherosclerosis.
Summary
The start and development of AS require different miRNAs. It reviews new research on miRNAs affecting endothelium, vascular smooth muscle, vascular inflammation, lipid retention, and cholesterol metabolism in AS. A miRNA gene expression profile circulates with AS everywhere. AS therapies include lipid metabolism, inflammation reduction, and oxidative stress inhibition. Clinical use of miRNAs requires tremendous progress. We think tiny miRNAs can enable personalized treatment.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38869707</pmid><doi>10.1007/s11883-024-01216-4</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-7728-0923</orcidid><orcidid>https://orcid.org/0000-0002-0136-7096</orcidid></addata></record> |
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| subjects | Angiology Animals Atherosclerosis - diagnosis Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - therapy Biomarkers - metabolism Cardiology Humans Medicine Medicine & Public Health MicroRNAs - genetics MicroRNAs - metabolism Prognosis Review Topical Collection on Vascular Biology |
| title | Unraveling the miRNA Puzzle in Atherosclerosis: Revolutionizing Diagnosis, Prognosis, and Therapeutic Approaches |
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