BRAF V600E-induced distinct DNA damage response defines the therapeutic potential of p53 activation for TP53 wild-type colorectal cancer

Abstract BRAF V600E, one of the most frequent mutations in the MAPK pathway, confers poor prognosis to colorectal cancers (CRCs), partly because of chemotherapeutic resistance. Oncogene-induced DNA damage responses (DDRs) that primarily activate p53 are important mechanistic barriers to the malignan...

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Veröffentlicht in:	Carcinogenesis (New York) 2024-11, Vol.45 (11), p.857-867
Hauptverfasser:	Tokuyama, Shinji, Kato, Hisakazu, Takahashi, Hidekazu, Ueda, Kyoko, Arita, Asami, Ueda, Ryuta, Seto, Hiroto, Sekido, Yuki, Hata, Tsuyoshi, Hamabe, Atsushi, Ogino, Takayuki, Miyoshi, Norikatsu, Uemura, Mamoru, Matsuoka, Ken, Tsukamoto, Osamu, Yamamoto, Hirofumi, Doki, Yuichiro, Eguchi, Hidetoshi, Takashima, Seiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cell Proliferation Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology DNA Damage Humans Mutation Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors Proto-Oncogene Proteins c-mdm2 - genetics Proto-Oncogene Proteins c-mdm2 - metabolism Signal Transduction Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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