Clinical effect of regional citrate anticoagulation continuous renal replacement therapy in three patients with hypercalcemic crisis
In this study, we investigated the effectiveness of regional citrate anticoagulation continuous renal replacement therapy (RCA-CRRT) in reducing blood calcium levels in three patients with hypercalcemia crisis caused by different etiologies. The sodium citrate chelation of calcium ions was utilized...
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| Veröffentlicht in: | International journal of artificial organs 2024-06, Vol.47 (6), p.369-372 |
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| container_title | International journal of artificial organs |
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| creator | Wang, Chunyan Xiang, Shilong |
| description | In this study, we investigated the effectiveness of regional citrate anticoagulation continuous renal replacement therapy (RCA-CRRT) in reducing blood calcium levels in three patients with hypercalcemia crisis caused by different etiologies. The sodium citrate chelation of calcium ions was utilized as an anticoagulant for treating severely affected patients. By adjusting the citrate anticoagulant dose and monitoring treatment indicators, RCA-CRRT parameters were actively modified to alleviate the hypercalcemia crisis and provide time for surgery or specialized treatment. Two patients experienced rapid and effective reductions in blood calcium levels, allowing for further treatment, while the third patient exhibited a repeated increase in blood calcium, which eventually decreased after parathyroid adenoma resection, leading to clinical discharge. Our findings suggest that RCA-CRRT can help alleviate hypercalcemia crisis, stabilize the patient’s internal environment, and provide valuable time for clinical treatment in cases of various medical conditions causing abnormal blood calcium elevations. |
| doi_str_mv | 10.1177/03913988241259963 |
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The sodium citrate chelation of calcium ions was utilized as an anticoagulant for treating severely affected patients. By adjusting the citrate anticoagulant dose and monitoring treatment indicators, RCA-CRRT parameters were actively modified to alleviate the hypercalcemia crisis and provide time for surgery or specialized treatment. Two patients experienced rapid and effective reductions in blood calcium levels, allowing for further treatment, while the third patient exhibited a repeated increase in blood calcium, which eventually decreased after parathyroid adenoma resection, leading to clinical discharge. Our findings suggest that RCA-CRRT can help alleviate hypercalcemia crisis, stabilize the patient’s internal environment, and provide valuable time for clinical treatment in cases of various medical conditions causing abnormal blood calcium elevations.</description><identifier>ISSN: 0391-3988</identifier><identifier>ISSN: 1724-6040</identifier><identifier>EISSN: 1724-6040</identifier><identifier>DOI: 10.1177/03913988241259963</identifier><identifier>PMID: 38869042</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aged ; Anticoagulants ; Anticoagulants - administration & dosage ; Anticoagulants - therapeutic use ; Blood ; Blood levels ; Calcium ; Calcium - blood ; Calcium ions ; Chelation ; Citric Acid ; Continuous Renal Replacement Therapy - methods ; Crises ; Effectiveness ; Female ; Health services ; Humans ; Hypercalcemia ; Hypercalcemia - blood ; Hypercalcemia - etiology ; Male ; Middle Aged ; Parameter modification ; Patients ; Sodium Citrate ; Treatment Outcome</subject><ispartof>International journal of artificial organs, 2024-06, Vol.47 (6), p.369-372</ispartof><rights>The Author(s) 2024</rights><rights>Copyright Wichtig Editore s.r.l. 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The sodium citrate chelation of calcium ions was utilized as an anticoagulant for treating severely affected patients. By adjusting the citrate anticoagulant dose and monitoring treatment indicators, RCA-CRRT parameters were actively modified to alleviate the hypercalcemia crisis and provide time for surgery or specialized treatment. Two patients experienced rapid and effective reductions in blood calcium levels, allowing for further treatment, while the third patient exhibited a repeated increase in blood calcium, which eventually decreased after parathyroid adenoma resection, leading to clinical discharge. Our findings suggest that RCA-CRRT can help alleviate hypercalcemia crisis, stabilize the patient’s internal environment, and provide valuable time for clinical treatment in cases of various medical conditions causing abnormal blood calcium elevations.</description><subject>Aged</subject><subject>Anticoagulants</subject><subject>Anticoagulants - administration & dosage</subject><subject>Anticoagulants - therapeutic use</subject><subject>Blood</subject><subject>Blood levels</subject><subject>Calcium</subject><subject>Calcium - blood</subject><subject>Calcium ions</subject><subject>Chelation</subject><subject>Citric Acid</subject><subject>Continuous Renal Replacement Therapy - methods</subject><subject>Crises</subject><subject>Effectiveness</subject><subject>Female</subject><subject>Health services</subject><subject>Humans</subject><subject>Hypercalcemia</subject><subject>Hypercalcemia - blood</subject><subject>Hypercalcemia - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Parameter modification</subject><subject>Patients</subject><subject>Sodium Citrate</subject><subject>Treatment Outcome</subject><issn>0391-3988</issn><issn>1724-6040</issn><issn>1724-6040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1LxDAQhoMouq7-AC8S8OKlmrRpkx5l8QsEL3ouaTrZjXTbmqTI3v3hTlk_QJEcJsw87zvMDCEnnF1wLuUly0qelUqlgqd5WRbZDplxmYqkYILtktlUTybggByG8MIYL4TI98lBplRRMpHOyPuidZ0zuqVgLZhIe0s9LF3fYcq46HUEqrvoTK-XY6sjVqjpMdGN_RiQnUAPQ6sNrKGLNK7A62FDXYdfD0AHFGEh0DcXV3S1GcBjP6Sdoca74MIR2bO6DXD8Gefk-eb6aXGXPDze3i-uHhKT5iwm1jZNU6ua86YWmVDGaJ4JsJIVuoRc8byQrFbMslqWuCDbCCmktLXJoahtmc3J-dZ38P3rCCFWaxcMtK3uAIepMlZMQsEVome_0Jd-9DjrROH2pMKHFN9SxvcheLDV4N1a-03FWTWdqPpzItScfjqP9Rqab8XXTRC42AJBL-Gn7f-OHwcbnBg</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Wang, Chunyan</creator><creator>Xiang, Shilong</creator><general>SAGE Publications</general><general>Wichtig Editore s.r.l</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7656-2876</orcidid><orcidid>https://orcid.org/0009-0002-1173-3480</orcidid></search><sort><creationdate>202406</creationdate><title>Clinical effect of regional citrate anticoagulation continuous renal replacement therapy in three patients with hypercalcemic crisis</title><author>Wang, Chunyan ; Xiang, Shilong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c250t-ffdddb8b11db4348cca134ef706a9e5815670b80f0b79117fd47477fbc5e6bf93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Anticoagulants</topic><topic>Anticoagulants - administration & dosage</topic><topic>Anticoagulants - therapeutic use</topic><topic>Blood</topic><topic>Blood levels</topic><topic>Calcium</topic><topic>Calcium - blood</topic><topic>Calcium ions</topic><topic>Chelation</topic><topic>Citric Acid</topic><topic>Continuous Renal Replacement Therapy - methods</topic><topic>Crises</topic><topic>Effectiveness</topic><topic>Female</topic><topic>Health services</topic><topic>Humans</topic><topic>Hypercalcemia</topic><topic>Hypercalcemia - blood</topic><topic>Hypercalcemia - etiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Parameter modification</topic><topic>Patients</topic><topic>Sodium Citrate</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Chunyan</creatorcontrib><creatorcontrib>Xiang, Shilong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of artificial organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Chunyan</au><au>Xiang, Shilong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical effect of regional citrate anticoagulation continuous renal replacement therapy in three patients with hypercalcemic crisis</atitle><jtitle>International journal of artificial organs</jtitle><addtitle>Int J Artif Organs</addtitle><date>2024-06</date><risdate>2024</risdate><volume>47</volume><issue>6</issue><spage>369</spage><epage>372</epage><pages>369-372</pages><issn>0391-3988</issn><issn>1724-6040</issn><eissn>1724-6040</eissn><abstract>In this study, we investigated the effectiveness of regional citrate anticoagulation continuous renal replacement therapy (RCA-CRRT) in reducing blood calcium levels in three patients with hypercalcemia crisis caused by different etiologies. The sodium citrate chelation of calcium ions was utilized as an anticoagulant for treating severely affected patients. By adjusting the citrate anticoagulant dose and monitoring treatment indicators, RCA-CRRT parameters were actively modified to alleviate the hypercalcemia crisis and provide time for surgery or specialized treatment. Two patients experienced rapid and effective reductions in blood calcium levels, allowing for further treatment, while the third patient exhibited a repeated increase in blood calcium, which eventually decreased after parathyroid adenoma resection, leading to clinical discharge. Our findings suggest that RCA-CRRT can help alleviate hypercalcemia crisis, stabilize the patient’s internal environment, and provide valuable time for clinical treatment in cases of various medical conditions causing abnormal blood calcium elevations.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>38869042</pmid><doi>10.1177/03913988241259963</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-7656-2876</orcidid><orcidid>https://orcid.org/0009-0002-1173-3480</orcidid></addata></record> |
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| subjects | Aged Anticoagulants Anticoagulants - administration & dosage Anticoagulants - therapeutic use Blood Blood levels Calcium Calcium - blood Calcium ions Chelation Citric Acid Continuous Renal Replacement Therapy - methods Crises Effectiveness Female Health services Humans Hypercalcemia Hypercalcemia - blood Hypercalcemia - etiology Male Middle Aged Parameter modification Patients Sodium Citrate Treatment Outcome |
| title | Clinical effect of regional citrate anticoagulation continuous renal replacement therapy in three patients with hypercalcemic crisis |
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