The biological characteristics of long cell-free DNA in spent embryos culture medium as noninvasive biomarker in in-vitro embryo selection

•A Tn5 transposase integrated dual sequencing strategy significantly improved the detection ratio of long cfDNA over 500bp.•A multiparametric index (TQI) displayed potential in differentiating top with normal quality in-vitro embryos (AUC=0.927).•TDual-Seq strategy has opened up analysis and potenti...

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Veröffentlicht in:	Gene 2024-11, Vol.927, p.148667, Article 148667
Hauptverfasser:	Pan, Min, Shi, Huajuan, Qi, Ting, Cai, Lingbo, Ge, Qinyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell-free DNA End motifs In-vitro embryo selection Long fragments Size distribution Spent embryo culture medium
Online-Zugang:	Volltext
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