Use of the 445‐nm Blue Laser for Management of Early Glottic Carcinoma: Preliminary 1‐Year Results
Objective To analyze oncological efficacy and voice outcomes of the 445‐nm blue laser (BL) in the treatment of early glottic carcinoma and compare results with the 532‐nm potassium‐titanyl‐phosphate (KTP) laser. Study Design Single institution, retrospective chart review. Methods All patients who un...
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| Veröffentlicht in: | The Laryngoscope 2024-11, Vol.134 (11), p.4656-4660 |
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| creator | Rosow, David E. Keidar, Eytan Pasick, Luke J. Casellas, Nicolas J. Anis, Mursalin M. |
| description | Objective
To analyze oncological efficacy and voice outcomes of the 445‐nm blue laser (BL) in the treatment of early glottic carcinoma and compare results with the 532‐nm potassium‐titanyl‐phosphate (KTP) laser.
Study Design
Single institution, retrospective chart review.
Methods
All patients who underwent microlaryngoscopic KTP or BL laser excision of early glottic carcinoma from 2018 to the present day with at least 1‐year follow‐up were included. Primary and recurrent disease, including radiation and surgical failures, were included. Demographic data, voice outcomes and oncologic outcomes were compared between the two laser groups.
Results
Forty‐nine patients met the inclusion criteria for the BL group and 88 for the KTP group, with average follow‐up of 635 and 1236 days, respectively. Oncologic outcomes were not significantly different, with disease‐specific survival rates of 95.9% for BL and 100% for KTP (p = 0.13), organ preservation rates of 98.0% for BL and 95.6% for KTP (p = 0.39), and local control rates of 93.9% for BL and 92.1% for KTP (p = 0.81). Both BL and KTP groups showed significant improvement in CAPE‐V (p = 0.04, 0.006 respectively) and VHI‐10 scores (p = 0.003, |
| doi_str_mv | 10.1002/lary.31569 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3066790250</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3066790250</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3529-b97133715159bbcb6a6100b8504f22e374115b7ad66a1dcf9b4c348b22f10c0c3</originalsourceid><addsrcrecordid>eNp9kM1u1DAUhS1URIfChgdAlrpBSBl8_ZPE3bWjtiANAo2oRFeW7bmBVE7S2onQ7PoIPGOfpB6mdNFFV3dxP3065xDyDtgcGOOfgo2buQBV6hdkBkpAIbVWe2SWn6KoFf-5T16ndMUYVEKxV2Rf1HXJpJAz0lwkpENDx99IpVR3t3_7jp6ECenSJoy0GSL9anv7Czvsxy15amPY0PMwjGPr6cJG3_ZDZ4_o94ih7do-p6GQRZdoI11hmsKY3pCXjQ0J3z7cA3Jxdvpj8blYfjv_sjheFl4orgunKxCiAgVKO-ddacvc0NWKyYZzFJUEUK6y67K0sPaNdtILWTvOG2CeeXFAPuy813G4mTCNpmuTxxBsj8OUjGBlWWnGFcvo4RP0aphin9MZASBrLpjeUh93lI9DShEbcx3bLlc0wMx2fbNd3_xbP8PvH5ST63D9iP6fOwOwA_60ATfPqMzyeHW5k94DPmCO5w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3114823090</pqid></control><display><type>article</type><title>Use of the 445‐nm Blue Laser for Management of Early Glottic Carcinoma: Preliminary 1‐Year Results</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Rosow, David E. ; Keidar, Eytan ; Pasick, Luke J. ; Casellas, Nicolas J. ; Anis, Mursalin M.</creator><creatorcontrib>Rosow, David E. ; Keidar, Eytan ; Pasick, Luke J. ; Casellas, Nicolas J. ; Anis, Mursalin M.</creatorcontrib><description>Objective
To analyze oncological efficacy and voice outcomes of the 445‐nm blue laser (BL) in the treatment of early glottic carcinoma and compare results with the 532‐nm potassium‐titanyl‐phosphate (KTP) laser.
Study Design
Single institution, retrospective chart review.
Methods
All patients who underwent microlaryngoscopic KTP or BL laser excision of early glottic carcinoma from 2018 to the present day with at least 1‐year follow‐up were included. Primary and recurrent disease, including radiation and surgical failures, were included. Demographic data, voice outcomes and oncologic outcomes were compared between the two laser groups.
Results
Forty‐nine patients met the inclusion criteria for the BL group and 88 for the KTP group, with average follow‐up of 635 and 1236 days, respectively. Oncologic outcomes were not significantly different, with disease‐specific survival rates of 95.9% for BL and 100% for KTP (p = 0.13), organ preservation rates of 98.0% for BL and 95.6% for KTP (p = 0.39), and local control rates of 93.9% for BL and 92.1% for KTP (p = 0.81). Both BL and KTP groups showed significant improvement in CAPE‐V (p = 0.04, 0.006 respectively) and VHI‐10 scores (p = 0.003, <0.00001) following surgery.
Conclusions
Photoangiolytic removal of early glottic carcinoma with BL appears to be equally safe and effective as with KTP laser at minimum one‐year follow‐up, and with excellent voice outcomes. Additional study will be warranted over time to assess long‐term outcomes in BL patients.
Level of Evidence
3 Laryngoscope, 134:4656–4660, 2024
The KTP laser has been well‐studied for its use in the photoangiolytic treatment of glottic cancer. Since the KTP laser ceased to be produced worldwide in 2018, the only photoangiolytic laser being produced for microlaryngeal surgery has been the 445‐nm blue laser. However, there have been no studies comparing the efficacy of the blue laser to KTP in treatment of glottic cancer, and this study seeks to rectify this.</description><identifier>ISSN: 0023-852X</identifier><identifier>ISSN: 1531-4995</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.31569</identifier><identifier>PMID: 38860434</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; blue laser ; Cancer ; Female ; Follow-Up Studies ; glottic cancer ; Glottis - pathology ; Glottis - surgery ; Humans ; KTP laser ; Laryngeal cancer ; Laryngeal Neoplasms - mortality ; Laryngeal Neoplasms - pathology ; Laryngeal Neoplasms - radiotherapy ; Laryngeal Neoplasms - surgery ; Laryngoscopy - methods ; laser ; Laser Therapy - methods ; Lasers ; Lasers, Solid-State - therapeutic use ; Male ; Middle Aged ; Retrospective Studies ; Treatment Outcome ; Voice Quality</subject><ispartof>The Laryngoscope, 2024-11, Vol.134 (11), p.4656-4660</ispartof><rights>2024 The Author(s). published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc.</rights><rights>2024 The Author(s). The Laryngoscope published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3529-b97133715159bbcb6a6100b8504f22e374115b7ad66a1dcf9b4c348b22f10c0c3</cites><orcidid>0000-0002-4289-0158 ; 0000-0002-3756-7858</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flary.31569$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flary.31569$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38860434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosow, David E.</creatorcontrib><creatorcontrib>Keidar, Eytan</creatorcontrib><creatorcontrib>Pasick, Luke J.</creatorcontrib><creatorcontrib>Casellas, Nicolas J.</creatorcontrib><creatorcontrib>Anis, Mursalin M.</creatorcontrib><title>Use of the 445‐nm Blue Laser for Management of Early Glottic Carcinoma: Preliminary 1‐Year Results</title><title>The Laryngoscope</title><addtitle>Laryngoscope</addtitle><description>Objective
To analyze oncological efficacy and voice outcomes of the 445‐nm blue laser (BL) in the treatment of early glottic carcinoma and compare results with the 532‐nm potassium‐titanyl‐phosphate (KTP) laser.
Study Design
Single institution, retrospective chart review.
Methods
All patients who underwent microlaryngoscopic KTP or BL laser excision of early glottic carcinoma from 2018 to the present day with at least 1‐year follow‐up were included. Primary and recurrent disease, including radiation and surgical failures, were included. Demographic data, voice outcomes and oncologic outcomes were compared between the two laser groups.
Results
Forty‐nine patients met the inclusion criteria for the BL group and 88 for the KTP group, with average follow‐up of 635 and 1236 days, respectively. Oncologic outcomes were not significantly different, with disease‐specific survival rates of 95.9% for BL and 100% for KTP (p = 0.13), organ preservation rates of 98.0% for BL and 95.6% for KTP (p = 0.39), and local control rates of 93.9% for BL and 92.1% for KTP (p = 0.81). Both BL and KTP groups showed significant improvement in CAPE‐V (p = 0.04, 0.006 respectively) and VHI‐10 scores (p = 0.003, <0.00001) following surgery.
Conclusions
Photoangiolytic removal of early glottic carcinoma with BL appears to be equally safe and effective as with KTP laser at minimum one‐year follow‐up, and with excellent voice outcomes. Additional study will be warranted over time to assess long‐term outcomes in BL patients.
Level of Evidence
3 Laryngoscope, 134:4656–4660, 2024
The KTP laser has been well‐studied for its use in the photoangiolytic treatment of glottic cancer. Since the KTP laser ceased to be produced worldwide in 2018, the only photoangiolytic laser being produced for microlaryngeal surgery has been the 445‐nm blue laser. However, there have been no studies comparing the efficacy of the blue laser to KTP in treatment of glottic cancer, and this study seeks to rectify this.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>blue laser</subject><subject>Cancer</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>glottic cancer</subject><subject>Glottis - pathology</subject><subject>Glottis - surgery</subject><subject>Humans</subject><subject>KTP laser</subject><subject>Laryngeal cancer</subject><subject>Laryngeal Neoplasms - mortality</subject><subject>Laryngeal Neoplasms - pathology</subject><subject>Laryngeal Neoplasms - radiotherapy</subject><subject>Laryngeal Neoplasms - surgery</subject><subject>Laryngoscopy - methods</subject><subject>laser</subject><subject>Laser Therapy - methods</subject><subject>Lasers</subject><subject>Lasers, Solid-State - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Treatment Outcome</subject><subject>Voice Quality</subject><issn>0023-852X</issn><issn>1531-4995</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp9kM1u1DAUhS1URIfChgdAlrpBSBl8_ZPE3bWjtiANAo2oRFeW7bmBVE7S2onQ7PoIPGOfpB6mdNFFV3dxP3065xDyDtgcGOOfgo2buQBV6hdkBkpAIbVWe2SWn6KoFf-5T16ndMUYVEKxV2Rf1HXJpJAz0lwkpENDx99IpVR3t3_7jp6ECenSJoy0GSL9anv7Czvsxy15amPY0PMwjGPr6cJG3_ZDZ4_o94ih7do-p6GQRZdoI11hmsKY3pCXjQ0J3z7cA3Jxdvpj8blYfjv_sjheFl4orgunKxCiAgVKO-ddacvc0NWKyYZzFJUEUK6y67K0sPaNdtILWTvOG2CeeXFAPuy813G4mTCNpmuTxxBsj8OUjGBlWWnGFcvo4RP0aphin9MZASBrLpjeUh93lI9DShEbcx3bLlc0wMx2fbNd3_xbP8PvH5ST63D9iP6fOwOwA_60ATfPqMzyeHW5k94DPmCO5w</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Rosow, David E.</creator><creator>Keidar, Eytan</creator><creator>Pasick, Luke J.</creator><creator>Casellas, Nicolas J.</creator><creator>Anis, Mursalin M.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4289-0158</orcidid><orcidid>https://orcid.org/0000-0002-3756-7858</orcidid></search><sort><creationdate>202411</creationdate><title>Use of the 445‐nm Blue Laser for Management of Early Glottic Carcinoma: Preliminary 1‐Year Results</title><author>Rosow, David E. ; Keidar, Eytan ; Pasick, Luke J. ; Casellas, Nicolas J. ; Anis, Mursalin M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3529-b97133715159bbcb6a6100b8504f22e374115b7ad66a1dcf9b4c348b22f10c0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>blue laser</topic><topic>Cancer</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>glottic cancer</topic><topic>Glottis - pathology</topic><topic>Glottis - surgery</topic><topic>Humans</topic><topic>KTP laser</topic><topic>Laryngeal cancer</topic><topic>Laryngeal Neoplasms - mortality</topic><topic>Laryngeal Neoplasms - pathology</topic><topic>Laryngeal Neoplasms - radiotherapy</topic><topic>Laryngeal Neoplasms - surgery</topic><topic>Laryngoscopy - methods</topic><topic>laser</topic><topic>Laser Therapy - methods</topic><topic>Lasers</topic><topic>Lasers, Solid-State - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Treatment Outcome</topic><topic>Voice Quality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosow, David E.</creatorcontrib><creatorcontrib>Keidar, Eytan</creatorcontrib><creatorcontrib>Pasick, Luke J.</creatorcontrib><creatorcontrib>Casellas, Nicolas J.</creatorcontrib><creatorcontrib>Anis, Mursalin M.</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosow, David E.</au><au>Keidar, Eytan</au><au>Pasick, Luke J.</au><au>Casellas, Nicolas J.</au><au>Anis, Mursalin M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of the 445‐nm Blue Laser for Management of Early Glottic Carcinoma: Preliminary 1‐Year Results</atitle><jtitle>The Laryngoscope</jtitle><addtitle>Laryngoscope</addtitle><date>2024-11</date><risdate>2024</risdate><volume>134</volume><issue>11</issue><spage>4656</spage><epage>4660</epage><pages>4656-4660</pages><issn>0023-852X</issn><issn>1531-4995</issn><eissn>1531-4995</eissn><abstract>Objective
To analyze oncological efficacy and voice outcomes of the 445‐nm blue laser (BL) in the treatment of early glottic carcinoma and compare results with the 532‐nm potassium‐titanyl‐phosphate (KTP) laser.
Study Design
Single institution, retrospective chart review.
Methods
All patients who underwent microlaryngoscopic KTP or BL laser excision of early glottic carcinoma from 2018 to the present day with at least 1‐year follow‐up were included. Primary and recurrent disease, including radiation and surgical failures, were included. Demographic data, voice outcomes and oncologic outcomes were compared between the two laser groups.
Results
Forty‐nine patients met the inclusion criteria for the BL group and 88 for the KTP group, with average follow‐up of 635 and 1236 days, respectively. Oncologic outcomes were not significantly different, with disease‐specific survival rates of 95.9% for BL and 100% for KTP (p = 0.13), organ preservation rates of 98.0% for BL and 95.6% for KTP (p = 0.39), and local control rates of 93.9% for BL and 92.1% for KTP (p = 0.81). Both BL and KTP groups showed significant improvement in CAPE‐V (p = 0.04, 0.006 respectively) and VHI‐10 scores (p = 0.003, <0.00001) following surgery.
Conclusions
Photoangiolytic removal of early glottic carcinoma with BL appears to be equally safe and effective as with KTP laser at minimum one‐year follow‐up, and with excellent voice outcomes. Additional study will be warranted over time to assess long‐term outcomes in BL patients.
Level of Evidence
3 Laryngoscope, 134:4656–4660, 2024
The KTP laser has been well‐studied for its use in the photoangiolytic treatment of glottic cancer. Since the KTP laser ceased to be produced worldwide in 2018, the only photoangiolytic laser being produced for microlaryngeal surgery has been the 445‐nm blue laser. However, there have been no studies comparing the efficacy of the blue laser to KTP in treatment of glottic cancer, and this study seeks to rectify this.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>38860434</pmid><doi>10.1002/lary.31569</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-4289-0158</orcidid><orcidid>https://orcid.org/0000-0002-3756-7858</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over blue laser Cancer Female Follow-Up Studies glottic cancer Glottis - pathology Glottis - surgery Humans KTP laser Laryngeal cancer Laryngeal Neoplasms - mortality Laryngeal Neoplasms - pathology Laryngeal Neoplasms - radiotherapy Laryngeal Neoplasms - surgery Laryngoscopy - methods laser Laser Therapy - methods Lasers Lasers, Solid-State - therapeutic use Male Middle Aged Retrospective Studies Treatment Outcome Voice Quality |
| title | Use of the 445‐nm Blue Laser for Management of Early Glottic Carcinoma: Preliminary 1‐Year Results |
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