Impact of BMI on serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D with calcifediol supplementation in young adults: a longitudinal study

Background High body mass index (BMI) is a risk factor for vitamin D deficiency. The rise in serum 25-hydroxyvitamin D [25(OH)D] concentrations following cholecalciferol supplementation is suboptimal, owing to adipose tissue sequestration and/or volumetric dilution. Calcifediol is a proven potent or...

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Veröffentlicht in:	Endocrine 2024-10, Vol.86 (1), p.391-399
Hauptverfasser:	Das, Liza, Sachdeva, Naresh, Holick, Michael F., Devnani, Mahesh, Dutta, Pinaki, Marwaha, Raman Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D Adipose tissue Body mass index Body weight Diabetes Dietary supplements Endocrinology Humanities and Social Sciences Internal Medicine Medicine Medicine & Public Health multidisciplinary Obesity Original Article Overweight Parathyroid hormone Risk factors Science Vitamin D Vitamin deficiency Young adults
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Zusammenfassung:	Background High body mass index (BMI) is a risk factor for vitamin D deficiency. The rise in serum 25-hydroxyvitamin D [25(OH)D] concentrations following cholecalciferol supplementation is suboptimal, owing to adipose tissue sequestration and/or volumetric dilution. Calcifediol is a proven potent oral alternative for vitamin D supplementation, but whether BMI adversely affects its efficacy in raising 25(OH)D concentrations, is not well known. Material and Methods Adults with serum concentrations of 25(OH)D 0.05). Conclusion BMI does not impede the rise in 25(OH)D concentrations following supplementation with calcifediol in young adults with vitamin D deficiency.
ISSN:	1559-0100 1355-008X 1559-0100
DOI:	10.1007/s12020-024-03895-0