Association between longitudinal changes in body composition and the risk of kidney outcomes in participants with overweight/obesity and type 2 diabetes mellitus
Aims To assess the relationship of longitudinal changes in fat mass (FM), lean mass (LM) and waist circumference (WC) with incident kidney outcomes in people with overweight/obesity and type 2 diabetes mellitus (T2DM). Materials and Methods A total of 3927 participants with baseline estimated glomer...
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| Veröffentlicht in: | Diabetes, obesity & metabolism obesity & metabolism, 2024-09, Vol.26 (9), p.3597-3605 |
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| container_title | Diabetes, obesity & metabolism |
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| creator | Zu, Cheng Liu, Mengyi Wang, Gangling Meng, Qiguo Gan, Xiaoqin He, Panpan Zhou, Chun Ye, Ziliang Wei, Yuanxiu Su, Xinyue Zhang, Yuanyuan Qin, Xianhui |
| description | Aims
To assess the relationship of longitudinal changes in fat mass (FM), lean mass (LM) and waist circumference (WC) with incident kidney outcomes in people with overweight/obesity and type 2 diabetes mellitus (T2DM).
Materials and Methods
A total of 3927 participants with baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 from the Look AHEAD (Action for Health in Diabetes) trial were included. The primary outcome was kidney outcomes, defined as a decrease in eGFR of at least 40% from baseline at follow‐up visit, or end‐stage kidney disease.
Results
During a median follow‐up of 8.0 years, 450 kidney outcomes were documented after the first 1 year. In the intensive lifestyle intervention (ILI) group, reductions in FM (per 10% decrease, adjusted hazard ratio [HR] 0.80, 95% confidence interval [CI] 0.69–0.94) and WC (per 10% decrease, adjusted HR 0.72, 95% CI 0.59–0.88) from baseline to 1‐year follow‐up were significantly associated with a lower risk of kidney outcomes. The change in LM was not significantly associated with risk of kidney outcomes (per 10% decrease, adjusted HR 0.78, 95% CI 0.58–1.06). In the diabetes support and education group (control group), no significant association was found between changes in body composition and kidney outcomes. Similar results were observed for the 4‐year changes in body composition.
Conclusions
In this post hoc analysis of the Look AHEAD trial, longitudinal declines in FM and WC were associated with a lower risk of kidney outcomes in the ILI group in participants with overweight/obesity and T2DM. |
| doi_str_mv | 10.1111/dom.15699 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3066338715</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3087919487</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2439-c85160cc9ff511218cca819b8a8fccc1445dd61a0e5cf040de439f02d762ea273</originalsourceid><addsrcrecordid>eNp1kctO3DAUhq2qiMuURV-gstRNWYTxJRdniSi0lUCzoevIY5_MGBI7tR1GeRzeFM-EdlEJb2zJ3__p6PwIfabkkqaz1K6_pEVZ1x_QKc1LnlHOyo-HN8tETdgJOgvhkRCSc1EdoxMuRMErmp-il6sQnDIyGmfxGuIOwOLO2Y2JozZWdlhtpd1AwCb9Oz1h5frBBXMISKtx3AL2Jjxh1-Inoy1M2I0xUXNmkD4aZQZpY8A7E7fYPYPfgdls49KtIZmm2TMNgBnWRqYxUraHrktDhE_oqJVdgPO3e4F-3948XP_M7lY_fl1f3WWK5bzOlChoSZSq27aglFGhlBS0XgspWqUUzfNC65JKAoVqSU40pFRLmK5KBpJVfIG-zd7Buz8jhNj0Jqg0hLTgxtBwUpY8rY8WCf36H_roRp-WtadEVdM6F3vhxUwp70Lw0DaDN730U0NJs--tSb01h94S--XNOK570P_Iv0UlYDkDO9PB9L6p-b66n5Wv_wmlhg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3087919487</pqid></control><display><type>article</type><title>Association between longitudinal changes in body composition and the risk of kidney outcomes in participants with overweight/obesity and type 2 diabetes mellitus</title><source>Access via Wiley Online Library</source><creator>Zu, Cheng ; Liu, Mengyi ; Wang, Gangling ; Meng, Qiguo ; Gan, Xiaoqin ; He, Panpan ; Zhou, Chun ; Ye, Ziliang ; Wei, Yuanxiu ; Su, Xinyue ; Zhang, Yuanyuan ; Qin, Xianhui</creator><creatorcontrib>Zu, Cheng ; Liu, Mengyi ; Wang, Gangling ; Meng, Qiguo ; Gan, Xiaoqin ; He, Panpan ; Zhou, Chun ; Ye, Ziliang ; Wei, Yuanxiu ; Su, Xinyue ; Zhang, Yuanyuan ; Qin, Xianhui</creatorcontrib><description>Aims
To assess the relationship of longitudinal changes in fat mass (FM), lean mass (LM) and waist circumference (WC) with incident kidney outcomes in people with overweight/obesity and type 2 diabetes mellitus (T2DM).
Materials and Methods
A total of 3927 participants with baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 from the Look AHEAD (Action for Health in Diabetes) trial were included. The primary outcome was kidney outcomes, defined as a decrease in eGFR of at least 40% from baseline at follow‐up visit, or end‐stage kidney disease.
Results
During a median follow‐up of 8.0 years, 450 kidney outcomes were documented after the first 1 year. In the intensive lifestyle intervention (ILI) group, reductions in FM (per 10% decrease, adjusted hazard ratio [HR] 0.80, 95% confidence interval [CI] 0.69–0.94) and WC (per 10% decrease, adjusted HR 0.72, 95% CI 0.59–0.88) from baseline to 1‐year follow‐up were significantly associated with a lower risk of kidney outcomes. The change in LM was not significantly associated with risk of kidney outcomes (per 10% decrease, adjusted HR 0.78, 95% CI 0.58–1.06). In the diabetes support and education group (control group), no significant association was found between changes in body composition and kidney outcomes. Similar results were observed for the 4‐year changes in body composition.
Conclusions
In this post hoc analysis of the Look AHEAD trial, longitudinal declines in FM and WC were associated with a lower risk of kidney outcomes in the ILI group in participants with overweight/obesity and T2DM.</description><identifier>ISSN: 1462-8902</identifier><identifier>ISSN: 1463-1326</identifier><identifier>EISSN: 1463-1326</identifier><identifier>DOI: 10.1111/dom.15699</identifier><identifier>PMID: 38853714</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Body composition ; Body fat ; Body measurements ; Body weight ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; diabetic nephropathy ; Epidermal growth factor receptors ; Glomerular filtration rate ; Kidney diseases ; Obesity ; Overweight ; type 2 diabetes ; weight control</subject><ispartof>Diabetes, obesity & metabolism, 2024-09, Vol.26 (9), p.3597-3605</ispartof><rights>2024 John Wiley & Sons Ltd.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2439-c85160cc9ff511218cca819b8a8fccc1445dd61a0e5cf040de439f02d762ea273</cites><orcidid>0000-0001-7812-7982</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdom.15699$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdom.15699$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38853714$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zu, Cheng</creatorcontrib><creatorcontrib>Liu, Mengyi</creatorcontrib><creatorcontrib>Wang, Gangling</creatorcontrib><creatorcontrib>Meng, Qiguo</creatorcontrib><creatorcontrib>Gan, Xiaoqin</creatorcontrib><creatorcontrib>He, Panpan</creatorcontrib><creatorcontrib>Zhou, Chun</creatorcontrib><creatorcontrib>Ye, Ziliang</creatorcontrib><creatorcontrib>Wei, Yuanxiu</creatorcontrib><creatorcontrib>Su, Xinyue</creatorcontrib><creatorcontrib>Zhang, Yuanyuan</creatorcontrib><creatorcontrib>Qin, Xianhui</creatorcontrib><title>Association between longitudinal changes in body composition and the risk of kidney outcomes in participants with overweight/obesity and type 2 diabetes mellitus</title><title>Diabetes, obesity & metabolism</title><addtitle>Diabetes Obes Metab</addtitle><description>Aims
To assess the relationship of longitudinal changes in fat mass (FM), lean mass (LM) and waist circumference (WC) with incident kidney outcomes in people with overweight/obesity and type 2 diabetes mellitus (T2DM).
Materials and Methods
A total of 3927 participants with baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 from the Look AHEAD (Action for Health in Diabetes) trial were included. The primary outcome was kidney outcomes, defined as a decrease in eGFR of at least 40% from baseline at follow‐up visit, or end‐stage kidney disease.
Results
During a median follow‐up of 8.0 years, 450 kidney outcomes were documented after the first 1 year. In the intensive lifestyle intervention (ILI) group, reductions in FM (per 10% decrease, adjusted hazard ratio [HR] 0.80, 95% confidence interval [CI] 0.69–0.94) and WC (per 10% decrease, adjusted HR 0.72, 95% CI 0.59–0.88) from baseline to 1‐year follow‐up were significantly associated with a lower risk of kidney outcomes. The change in LM was not significantly associated with risk of kidney outcomes (per 10% decrease, adjusted HR 0.78, 95% CI 0.58–1.06). In the diabetes support and education group (control group), no significant association was found between changes in body composition and kidney outcomes. Similar results were observed for the 4‐year changes in body composition.
Conclusions
In this post hoc analysis of the Look AHEAD trial, longitudinal declines in FM and WC were associated with a lower risk of kidney outcomes in the ILI group in participants with overweight/obesity and T2DM.</description><subject>Body composition</subject><subject>Body fat</subject><subject>Body measurements</subject><subject>Body weight</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>diabetic nephropathy</subject><subject>Epidermal growth factor receptors</subject><subject>Glomerular filtration rate</subject><subject>Kidney diseases</subject><subject>Obesity</subject><subject>Overweight</subject><subject>type 2 diabetes</subject><subject>weight control</subject><issn>1462-8902</issn><issn>1463-1326</issn><issn>1463-1326</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kctO3DAUhq2qiMuURV-gstRNWYTxJRdniSi0lUCzoevIY5_MGBI7tR1GeRzeFM-EdlEJb2zJ3__p6PwIfabkkqaz1K6_pEVZ1x_QKc1LnlHOyo-HN8tETdgJOgvhkRCSc1EdoxMuRMErmp-il6sQnDIyGmfxGuIOwOLO2Y2JozZWdlhtpd1AwCb9Oz1h5frBBXMISKtx3AL2Jjxh1-Inoy1M2I0xUXNmkD4aZQZpY8A7E7fYPYPfgdls49KtIZmm2TMNgBnWRqYxUraHrktDhE_oqJVdgPO3e4F-3948XP_M7lY_fl1f3WWK5bzOlChoSZSq27aglFGhlBS0XgspWqUUzfNC65JKAoVqSU40pFRLmK5KBpJVfIG-zd7Buz8jhNj0Jqg0hLTgxtBwUpY8rY8WCf36H_roRp-WtadEVdM6F3vhxUwp70Lw0DaDN730U0NJs--tSb01h94S--XNOK570P_Iv0UlYDkDO9PB9L6p-b66n5Wv_wmlhg</recordid><startdate>202409</startdate><enddate>202409</enddate><creator>Zu, Cheng</creator><creator>Liu, Mengyi</creator><creator>Wang, Gangling</creator><creator>Meng, Qiguo</creator><creator>Gan, Xiaoqin</creator><creator>He, Panpan</creator><creator>Zhou, Chun</creator><creator>Ye, Ziliang</creator><creator>Wei, Yuanxiu</creator><creator>Su, Xinyue</creator><creator>Zhang, Yuanyuan</creator><creator>Qin, Xianhui</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7812-7982</orcidid></search><sort><creationdate>202409</creationdate><title>Association between longitudinal changes in body composition and the risk of kidney outcomes in participants with overweight/obesity and type 2 diabetes mellitus</title><author>Zu, Cheng ; Liu, Mengyi ; Wang, Gangling ; Meng, Qiguo ; Gan, Xiaoqin ; He, Panpan ; Zhou, Chun ; Ye, Ziliang ; Wei, Yuanxiu ; Su, Xinyue ; Zhang, Yuanyuan ; Qin, Xianhui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2439-c85160cc9ff511218cca819b8a8fccc1445dd61a0e5cf040de439f02d762ea273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Body composition</topic><topic>Body fat</topic><topic>Body measurements</topic><topic>Body weight</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>diabetic nephropathy</topic><topic>Epidermal growth factor receptors</topic><topic>Glomerular filtration rate</topic><topic>Kidney diseases</topic><topic>Obesity</topic><topic>Overweight</topic><topic>type 2 diabetes</topic><topic>weight control</topic><toplevel>online_resources</toplevel><creatorcontrib>Zu, Cheng</creatorcontrib><creatorcontrib>Liu, Mengyi</creatorcontrib><creatorcontrib>Wang, Gangling</creatorcontrib><creatorcontrib>Meng, Qiguo</creatorcontrib><creatorcontrib>Gan, Xiaoqin</creatorcontrib><creatorcontrib>He, Panpan</creatorcontrib><creatorcontrib>Zhou, Chun</creatorcontrib><creatorcontrib>Ye, Ziliang</creatorcontrib><creatorcontrib>Wei, Yuanxiu</creatorcontrib><creatorcontrib>Su, Xinyue</creatorcontrib><creatorcontrib>Zhang, Yuanyuan</creatorcontrib><creatorcontrib>Qin, Xianhui</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes, obesity & metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zu, Cheng</au><au>Liu, Mengyi</au><au>Wang, Gangling</au><au>Meng, Qiguo</au><au>Gan, Xiaoqin</au><au>He, Panpan</au><au>Zhou, Chun</au><au>Ye, Ziliang</au><au>Wei, Yuanxiu</au><au>Su, Xinyue</au><au>Zhang, Yuanyuan</au><au>Qin, Xianhui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between longitudinal changes in body composition and the risk of kidney outcomes in participants with overweight/obesity and type 2 diabetes mellitus</atitle><jtitle>Diabetes, obesity & metabolism</jtitle><addtitle>Diabetes Obes Metab</addtitle><date>2024-09</date><risdate>2024</risdate><volume>26</volume><issue>9</issue><spage>3597</spage><epage>3605</epage><pages>3597-3605</pages><issn>1462-8902</issn><issn>1463-1326</issn><eissn>1463-1326</eissn><abstract>Aims
To assess the relationship of longitudinal changes in fat mass (FM), lean mass (LM) and waist circumference (WC) with incident kidney outcomes in people with overweight/obesity and type 2 diabetes mellitus (T2DM).
Materials and Methods
A total of 3927 participants with baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 from the Look AHEAD (Action for Health in Diabetes) trial were included. The primary outcome was kidney outcomes, defined as a decrease in eGFR of at least 40% from baseline at follow‐up visit, or end‐stage kidney disease.
Results
During a median follow‐up of 8.0 years, 450 kidney outcomes were documented after the first 1 year. In the intensive lifestyle intervention (ILI) group, reductions in FM (per 10% decrease, adjusted hazard ratio [HR] 0.80, 95% confidence interval [CI] 0.69–0.94) and WC (per 10% decrease, adjusted HR 0.72, 95% CI 0.59–0.88) from baseline to 1‐year follow‐up were significantly associated with a lower risk of kidney outcomes. The change in LM was not significantly associated with risk of kidney outcomes (per 10% decrease, adjusted HR 0.78, 95% CI 0.58–1.06). In the diabetes support and education group (control group), no significant association was found between changes in body composition and kidney outcomes. Similar results were observed for the 4‐year changes in body composition.
Conclusions
In this post hoc analysis of the Look AHEAD trial, longitudinal declines in FM and WC were associated with a lower risk of kidney outcomes in the ILI group in participants with overweight/obesity and T2DM.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>38853714</pmid><doi>10.1111/dom.15699</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7812-7982</orcidid></addata></record> |
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| subjects | Body composition Body fat Body measurements Body weight Diabetes Diabetes mellitus (non-insulin dependent) diabetic nephropathy Epidermal growth factor receptors Glomerular filtration rate Kidney diseases Obesity Overweight type 2 diabetes weight control |
| title | Association between longitudinal changes in body composition and the risk of kidney outcomes in participants with overweight/obesity and type 2 diabetes mellitus |
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