METTL3 Promotes Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration by Regulating TLR2 m6A Methylation and Gut Microbiota

Abstract Background Nucleus pulposus cell (NPC) senescence in intervertebral disc (IVD) tissue is the major pathological cause of intervertebral disc degeneration (IDD). N6-methyladenosine (m6A) methylation and gut microbiota play important roles in the progression of IDD. This study investigated wh...

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Veröffentlicht in:	The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2024-08, Vol.79 (8)
Hauptverfasser:	Ni, Shuangfei, Huang, Xiusheng, Li, Xuesen, Shi, Chenhao, Fan, Mingzhe, Zhao, Lantian, Rong, Zijie, Zhang, Huafeng
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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