Tricetin protects against liver fibrosis through promoting autophagy and Nrf2 signaling in hepatic stellate cells

The study aims to investigate the role and underlying mechanisms of tricetin in regulating hepatic stellate cells (HSCs) activation. We treated human hepatic stellate cells line LX-2 and freshly isolated primary mouse hepatic stellate cells (mHSCs) with tricetin, pharmacological inhibitors and siRNA...

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Veröffentlicht in:	Life sciences (1973) 2024-08, Vol.351, p.122798, Article 122798
Hauptverfasser:	Li, Wanzhi, Lv, Ruyue, Zou, Tangbin, Chen, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Autophagy - drug effects Cell Line Cell Proliferation - drug effects Hepatic stellate cell activation Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - metabolism Hepatic Stellate Cells - pathology Humans Liver Cirrhosis - drug therapy Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Male Mice Mice, Inbred C57BL NF-E2-Related Factor 2 - metabolism Nrf2 Reactive Oxygen Species - metabolism ROS Signal Transduction - drug effects Tricetin
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