Oncostatin M reverses ABCG2-mediated mitoxantrone resistance

Mitoxantrone resistant variant of SW620 line was developed, characterized and subsequently used as a model system to determine oncostatin M ability to modulate MDR phenomenon. The selection regimen allowed for overexpression of ABCG2 and ABCB1 both at the RNA and protein level, which was further con...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2024-07, Vol.176, p.116861, Article 116861
Hauptverfasser:	Błauż, Andrzej, Wachulec, Marcin, Rychlik, Błażej
Format:	Artikel
Sprache:	eng
Schlagworte:	Oncostatin M mitoxantrone Multidrug resistance
Online-Zugang:	Volltext
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