Spatiotemporal release of non-nucleotide STING agonist and AKT inhibitor from implantable 3D-printed scaffold for amplified cancer immunotherapy

Immunotherapy through the activation of the stimulator of interferon genes (STING) signaling pathway is increasingly recognized for its robust anti-tumor efficacy. However, the effectiveness of STING activation is often compromised by inadequate anti-tumor immunity and a scarcity of primed immune ce...

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Veröffentlicht in:Biomaterials 2024-12, Vol.311, p.122645, Article 122645
Hauptverfasser: Wang, Haixia, Liu, Zheng, Fang, Youqiang, Luo, Xing, Zheng, Chunxiong, Xu, Yanteng, Zhou, Xiangfu, Yuan, Qing, Lv, Shixian, Ma, Limin, Lao, Yeh-Hsing, Tao, Yu, Li, Mingqiang
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Sprache:eng
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