Effects and mechanisms of sciadonic acid on colonic transit function through regulating 5-HT4/cAMP/PKA/AQP4 signaling pathway in STC model mice

•Sciadonic acid (SA), a unique fatty acid found in T. grandis oil, has been discovered to effectively alleviate STC.•SA improves gut motility by modulating the intestinal microbiota and activating the 5-HT4-cAMP-PKA-AQP4 pathway.•The study explored the mechanism from the perspective of brain-gut-mic...

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Veröffentlicht in:	The Journal of nutritional biochemistry 2024-09, Vol.131, p.109676, Article 109676
Hauptverfasser:	Yu, Zhuoli, Zikela, Lalai, Wang, Dingli, Wang, Xuezhu, Zhu, Huilin, Li, Songtao, Han, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	5-hydroxytryptamine Aquaporin-4 Sciadonic acid Slow transit constipation
Online-Zugang:	Volltext
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