Modelling the role of enzymatic pathways in the metabolism of docosahexaenoic acid by monocytes and its association with osteoarthritic pain

Chronic pain is a major cause of disability and suffering in osteoarthritis (OA) patients. Endogenous specialised pro-resolving molecules (SPMs) curtail pro-inflammatory responses. One of the SPM intermediate oxylipins, 17-hydroxydocasahexaenoic acid (17-HDHA, a metabolite of docosahexaenoic acid (D...

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Veröffentlicht in:	Mathematical biosciences 2024-08, Vol.374, p.109228, Article 109228
Hauptverfasser:	Franks, S.J., Gowler, P.R.W., Dunster, J.L., Turnbull, J., Gohir, S.A., Kelly, A., Valdes, A.M., King, J.R., Barrett, D.A., Chapman, V., Preston, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Docosahexaenoic acid Gene expression Mathematical model Metabolites Osteoarthritis
Online-Zugang:	Volltext
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