From bile acids to melancholia

From bile acids to melancholia

In this issue of Neuron, Li, Zhang, et al.1 find that the bile acid receptor TGR5 in the lateral hypothalamus influences neuronal dynamics underlying stress-induced depression-like behaviors. Inhibition of these neurons produces antidepressant-like effects through a circuit that includes hippocampal...

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Veröffentlicht in:Neuron (Cambridge, Mass.) Mass.), 2024-06, Vol.112 (11), p.1725-1727
Hauptverfasser: Klein, Alexandra S., Kheirbek, Mazen A.
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Sprache:eng
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Animals
Bile Acids and Salts - metabolism
Depression - metabolism
Humans
Receptors, G-Protein-Coupled - metabolism
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container_issue 11
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container_title Neuron (Cambridge, Mass.)
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creator Klein, Alexandra S.
Kheirbek, Mazen A.
description In this issue of Neuron, Li, Zhang, et al.1 find that the bile acid receptor TGR5 in the lateral hypothalamus influences neuronal dynamics underlying stress-induced depression-like behaviors. Inhibition of these neurons produces antidepressant-like effects through a circuit that includes hippocampal CA3 and dorsolateral septum, revealing a novel potential therapeutic for depression. In this issue of Neuron, Li, Zhang, et al. find that the bile acid receptor TGR5 in the lateral hypothalamus influences neuronal dynamics underlying stress-induced depression-like behaviors. Inhibition of these neurons produces antidepressant-like effects through a circuit that includes hippocampal CA3 and dorsolateral septum, revealing a novel potential therapeutic for depression.
doi_str_mv 10.1016/j.neuron.2024.05.007
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subjects Animals
Bile Acids and Salts - metabolism
Depression - metabolism
Humans
Receptors, G-Protein-Coupled - metabolism
title From bile acids to melancholia
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