Productive cough, a forgotten phenotype of refractory chronic cough

Refractory chronic cough (RCC) patients typically complain of a dry cough. Sputum production in these patients has rarely been described in the literature. However, sputum production in RCC may be common, troublesome and particularly challenging to manage. We aimed to characterise patients referred...

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Veröffentlicht in:Respiratory medicine and research 2024-11, Vol.86, p.101106, Article 101106
Hauptverfasser: King, Jenny, Digby, James Wingfield, Hennessey, Sarah, Marsden, Paul, Smith, Jaclyn
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container_title Respiratory medicine and research
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creator King, Jenny
Digby, James Wingfield
Hennessey, Sarah
Marsden, Paul
Smith, Jaclyn
description Refractory chronic cough (RCC) patients typically complain of a dry cough. Sputum production in these patients has rarely been described in the literature. However, sputum production in RCC may be common, troublesome and particularly challenging to manage. We aimed to characterise patients referred to our regional specialist cough clinic who have significant sputum production (≥1 teaspoon of sputum daily) and compare their demographics, symptomatology and investigation results to those presenting with a dry RCC. A retrospective case note analysis of all consecutive referrals to a tertiary cough clinic identified as having a productive cough (≥1 teaspoon of sputum daily) was performed over a 12-month period. They were compared to a paired number of patients with dry RCC. Patients with productive cough represented nearly a quarter (98/398, 24.6 %) of new patient referrals to the clinic. Demographic information, symptomatology and investigation results were comparable to those with a dry RCC. Over a third, 35.8 % of patients with a productive cough reported expectorating an egg-cupful of sputum or more a day. Nearly half, 40% of those with high volume sputum production (≥egg-cupful daily) had both a normal CT thorax and normal spirometry. Patients with RCC can expectorate significant volumes of sputum in the absence of underlying lung disease. This group have similar demographics to those with dry RCC. This is the first piece of work to our knowledge to describe this cohort. Future work needs to acknowledge this forgotten phenotype to ensure that they receive comprehensive evaluation and evidenced based treatment.
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Over a third, 35.8 % of patients with a productive cough reported expectorating an egg-cupful of sputum or more a day. Nearly half, 40% of those with high volume sputum production (≥egg-cupful daily) had both a normal CT thorax and normal spirometry. Patients with RCC can expectorate significant volumes of sputum in the absence of underlying lung disease. This group have similar demographics to those with dry RCC. This is the first piece of work to our knowledge to describe this cohort. 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source MEDLINE; Alma/SFX Local Collection
subjects Adult
Aged
Asthma
Bronchiectasis
Chronic Cough
Chronic Disease
Cough
Cough - diagnosis
Cough - etiology
Cough - physiopathology
Cough - therapy
Female
Humans
Male
Middle Aged
Phenotype
Retrospective Studies
Sputum
title Productive cough, a forgotten phenotype of refractory chronic cough
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