Productive cough, a forgotten phenotype of refractory chronic cough
Refractory chronic cough (RCC) patients typically complain of a dry cough. Sputum production in these patients has rarely been described in the literature. However, sputum production in RCC may be common, troublesome and particularly challenging to manage. We aimed to characterise patients referred...
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description | Refractory chronic cough (RCC) patients typically complain of a dry cough. Sputum production in these patients has rarely been described in the literature. However, sputum production in RCC may be common, troublesome and particularly challenging to manage.
We aimed to characterise patients referred to our regional specialist cough clinic who have significant sputum production (≥1 teaspoon of sputum daily) and compare their demographics, symptomatology and investigation results to those presenting with a dry RCC.
A retrospective case note analysis of all consecutive referrals to a tertiary cough clinic identified as having a productive cough (≥1 teaspoon of sputum daily) was performed over a 12-month period. They were compared to a paired number of patients with dry RCC.
Patients with productive cough represented nearly a quarter (98/398, 24.6 %) of new patient referrals to the clinic. Demographic information, symptomatology and investigation results were comparable to those with a dry RCC. Over a third, 35.8 % of patients with a productive cough reported expectorating an egg-cupful of sputum or more a day. Nearly half, 40% of those with high volume sputum production (≥egg-cupful daily) had both a normal CT thorax and normal spirometry.
Patients with RCC can expectorate significant volumes of sputum in the absence of underlying lung disease. This group have similar demographics to those with dry RCC. This is the first piece of work to our knowledge to describe this cohort. Future work needs to acknowledge this forgotten phenotype to ensure that they receive comprehensive evaluation and evidenced based treatment. |
doi_str_mv | 10.1016/j.resmer.2024.101106 |
format | Article |
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We aimed to characterise patients referred to our regional specialist cough clinic who have significant sputum production (≥1 teaspoon of sputum daily) and compare their demographics, symptomatology and investigation results to those presenting with a dry RCC.
A retrospective case note analysis of all consecutive referrals to a tertiary cough clinic identified as having a productive cough (≥1 teaspoon of sputum daily) was performed over a 12-month period. They were compared to a paired number of patients with dry RCC.
Patients with productive cough represented nearly a quarter (98/398, 24.6 %) of new patient referrals to the clinic. Demographic information, symptomatology and investigation results were comparable to those with a dry RCC. Over a third, 35.8 % of patients with a productive cough reported expectorating an egg-cupful of sputum or more a day. Nearly half, 40% of those with high volume sputum production (≥egg-cupful daily) had both a normal CT thorax and normal spirometry.
Patients with RCC can expectorate significant volumes of sputum in the absence of underlying lung disease. This group have similar demographics to those with dry RCC. This is the first piece of work to our knowledge to describe this cohort. Future work needs to acknowledge this forgotten phenotype to ensure that they receive comprehensive evaluation and evidenced based treatment.</description><identifier>ISSN: 2590-0412</identifier><identifier>EISSN: 2590-0412</identifier><identifier>DOI: 10.1016/j.resmer.2024.101106</identifier><identifier>PMID: 38843596</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Adult ; Aged ; Asthma ; Bronchiectasis ; Chronic Cough ; Chronic Disease ; Cough ; Cough - diagnosis ; Cough - etiology ; Cough - physiopathology ; Cough - therapy ; Female ; Humans ; Male ; Middle Aged ; Phenotype ; Retrospective Studies ; Sputum</subject><ispartof>Respiratory medicine and research, 2024-11, Vol.86, p.101106, Article 101106</ispartof><rights>2024</rights><rights>Crown Copyright © 2024. Published by Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1921-92fccbbc0385689268c4bd4ceaea31d67fc861ff36c663b48bbf0301ed6ae1163</cites><orcidid>0000-0002-4191-6854 ; 0000-0002-9975-8801 ; 0000-0002-0834-4911</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38843596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>King, Jenny</creatorcontrib><creatorcontrib>Digby, James Wingfield</creatorcontrib><creatorcontrib>Hennessey, Sarah</creatorcontrib><creatorcontrib>Marsden, Paul</creatorcontrib><creatorcontrib>Smith, Jaclyn</creatorcontrib><title>Productive cough, a forgotten phenotype of refractory chronic cough</title><title>Respiratory medicine and research</title><addtitle>Respir Med Res</addtitle><description>Refractory chronic cough (RCC) patients typically complain of a dry cough. Sputum production in these patients has rarely been described in the literature. However, sputum production in RCC may be common, troublesome and particularly challenging to manage.
We aimed to characterise patients referred to our regional specialist cough clinic who have significant sputum production (≥1 teaspoon of sputum daily) and compare their demographics, symptomatology and investigation results to those presenting with a dry RCC.
A retrospective case note analysis of all consecutive referrals to a tertiary cough clinic identified as having a productive cough (≥1 teaspoon of sputum daily) was performed over a 12-month period. They were compared to a paired number of patients with dry RCC.
Patients with productive cough represented nearly a quarter (98/398, 24.6 %) of new patient referrals to the clinic. Demographic information, symptomatology and investigation results were comparable to those with a dry RCC. Over a third, 35.8 % of patients with a productive cough reported expectorating an egg-cupful of sputum or more a day. Nearly half, 40% of those with high volume sputum production (≥egg-cupful daily) had both a normal CT thorax and normal spirometry.
Patients with RCC can expectorate significant volumes of sputum in the absence of underlying lung disease. This group have similar demographics to those with dry RCC. This is the first piece of work to our knowledge to describe this cohort. Future work needs to acknowledge this forgotten phenotype to ensure that they receive comprehensive evaluation and evidenced based treatment.</description><subject>Adult</subject><subject>Aged</subject><subject>Asthma</subject><subject>Bronchiectasis</subject><subject>Chronic Cough</subject><subject>Chronic Disease</subject><subject>Cough</subject><subject>Cough - diagnosis</subject><subject>Cough - etiology</subject><subject>Cough - physiopathology</subject><subject>Cough - therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Phenotype</subject><subject>Retrospective Studies</subject><subject>Sputum</subject><issn>2590-0412</issn><issn>2590-0412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRbKn9ByI5ejB1v7LdXAQpfkFBD3peNpPZNqXJ1t1E6L83JVU8eZpheN-ZeR9CLhmdMcrU7WYWMNYYZpxyeRgxqk7ImGc5Talk_PRPPyLTGDeUUs7mjGp5TkZCaymyXI3J4i34soO2-sIEfLda3yQ2cT6sfNtik-zW2Ph2v8PEuySgCxZaH_YJrINvKhgsF-TM2W3E6bFOyMfjw_viOV2-Pr0s7pcpsJyzNOcOoCiACp0pnXOlQRalBLRoBSvV3IFWzDmhQClRSF0UjgrKsFQWGVNiQq6HvbvgPzuMramrCLjd2gZ9F42gKsv7YHreS-UgheBj7B83u1DVNuwNo-ZA0GzMQNAcCJqBYG-7Ol7oihrLX9MPr15wNwiwz_lV9fYIFTaAZRUQWlP66v8L31PAg6Y</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>King, Jenny</creator><creator>Digby, James Wingfield</creator><creator>Hennessey, Sarah</creator><creator>Marsden, Paul</creator><creator>Smith, Jaclyn</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4191-6854</orcidid><orcidid>https://orcid.org/0000-0002-9975-8801</orcidid><orcidid>https://orcid.org/0000-0002-0834-4911</orcidid></search><sort><creationdate>202411</creationdate><title>Productive cough, a forgotten phenotype of refractory chronic cough</title><author>King, Jenny ; Digby, James Wingfield ; Hennessey, Sarah ; Marsden, Paul ; Smith, Jaclyn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1921-92fccbbc0385689268c4bd4ceaea31d67fc861ff36c663b48bbf0301ed6ae1163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Asthma</topic><topic>Bronchiectasis</topic><topic>Chronic Cough</topic><topic>Chronic Disease</topic><topic>Cough</topic><topic>Cough - diagnosis</topic><topic>Cough - etiology</topic><topic>Cough - physiopathology</topic><topic>Cough - therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Phenotype</topic><topic>Retrospective Studies</topic><topic>Sputum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>King, Jenny</creatorcontrib><creatorcontrib>Digby, James Wingfield</creatorcontrib><creatorcontrib>Hennessey, Sarah</creatorcontrib><creatorcontrib>Marsden, Paul</creatorcontrib><creatorcontrib>Smith, Jaclyn</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine and research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>King, Jenny</au><au>Digby, James Wingfield</au><au>Hennessey, Sarah</au><au>Marsden, Paul</au><au>Smith, Jaclyn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Productive cough, a forgotten phenotype of refractory chronic cough</atitle><jtitle>Respiratory medicine and research</jtitle><addtitle>Respir Med Res</addtitle><date>2024-11</date><risdate>2024</risdate><volume>86</volume><spage>101106</spage><pages>101106-</pages><artnum>101106</artnum><issn>2590-0412</issn><eissn>2590-0412</eissn><abstract>Refractory chronic cough (RCC) patients typically complain of a dry cough. Sputum production in these patients has rarely been described in the literature. However, sputum production in RCC may be common, troublesome and particularly challenging to manage.
We aimed to characterise patients referred to our regional specialist cough clinic who have significant sputum production (≥1 teaspoon of sputum daily) and compare their demographics, symptomatology and investigation results to those presenting with a dry RCC.
A retrospective case note analysis of all consecutive referrals to a tertiary cough clinic identified as having a productive cough (≥1 teaspoon of sputum daily) was performed over a 12-month period. They were compared to a paired number of patients with dry RCC.
Patients with productive cough represented nearly a quarter (98/398, 24.6 %) of new patient referrals to the clinic. Demographic information, symptomatology and investigation results were comparable to those with a dry RCC. Over a third, 35.8 % of patients with a productive cough reported expectorating an egg-cupful of sputum or more a day. Nearly half, 40% of those with high volume sputum production (≥egg-cupful daily) had both a normal CT thorax and normal spirometry.
Patients with RCC can expectorate significant volumes of sputum in the absence of underlying lung disease. This group have similar demographics to those with dry RCC. This is the first piece of work to our knowledge to describe this cohort. Future work needs to acknowledge this forgotten phenotype to ensure that they receive comprehensive evaluation and evidenced based treatment.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>38843596</pmid><doi>10.1016/j.resmer.2024.101106</doi><orcidid>https://orcid.org/0000-0002-4191-6854</orcidid><orcidid>https://orcid.org/0000-0002-9975-8801</orcidid><orcidid>https://orcid.org/0000-0002-0834-4911</orcidid></addata></record> |
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subjects | Adult Aged Asthma Bronchiectasis Chronic Cough Chronic Disease Cough Cough - diagnosis Cough - etiology Cough - physiopathology Cough - therapy Female Humans Male Middle Aged Phenotype Retrospective Studies Sputum |
title | Productive cough, a forgotten phenotype of refractory chronic cough |
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