Application of newly developed and validated LC-MS/MS method for pharmacokinetic study of adagrasib and pembrolizumab simultaneously in rat plasma

•Developed an LC-MS/MS method for the simultaneous determination of new FDA approved anticancer drugs in rat plasma.•The developed method was validated as per USFDA guidelines including stability parameters.•The developed LC-MS/MS method was efficiently employed in an in vivo pharmacokinetic study o...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2024-07, Vol.1241, p.124171, Article 124171
Hauptverfasser:	Harsha Sri, Kamma, Ravisankar, Panchumarthy, Kumar Konidala, Sathish, Srinivasa Babu, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adagrasib Bio-analytical method LC-MS/MS Pembrolizumab Pharmacokinetic study
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