Capturing totipotency in human cells through spliceosomal repression

The cleavage of zygotes generates totipotent blastomeres. In human 8-cell blastomeres, zygotic genome activation (ZGA) occurs to initiate the ontogenesis program. However, capturing and maintaining totipotency in human cells pose significant challenges. Here, we realize culturing human totipotent bl...

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Veröffentlicht in:	Cell 2024-06, Vol.187 (13), p.3284-3302.e23
Hauptverfasser:	Li, Shiyu, Yang, Min, Shen, Hui, Ding, Li, Lyu, Xuehui, Lin, Kexin, Ong, Jennie, Du, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blastocyst - cytology Blastocyst - metabolism blastocyst-like structure blastomere Blastomeres - cytology Blastomeres - metabolism Cell Differentiation Cellular Reprogramming Embryonic Development - genetics Germ Layers - cytology Germ Layers - metabolism Humans Mice pluripotent Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism RNA Splicing Spliceosomes - metabolism splicing inhibition stem cell culture totipotency totipotent blastomere-like cells Totipotent Stem Cells - cytology Totipotent Stem Cells - metabolism ZGA-like cells Zygote - metabolism zygotic genomic activation
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