Translational control by VARS in melanoma

Translational control by VARS in melanoma

Aminoacyl-tRNA synthetases can promote or suppress cancer progression by regulating codon-dependent translation. A study now shows that valine aminoacyl-tRNA synthetase (VARS) promotes therapeutic resistance of melanoma to MAPK pathway inhibitors by enhancing translation of valine-enriched genes, in...

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Veröffentlicht in:Nature cell biology 2024-07, Vol.26 (7), p.1023-1024
Hauptverfasser: Wu, Qiushuang, Tavazoie, Sohail F.
Format: Artikel
Sprache:eng
Schlagworte:
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Acid resistance
Amino acids
Aminoacyl-tRNA ligase
Biology
Biomedical and Life Sciences
Cancer
Cancer Research
Cell Biology
Developmental Biology
Drug resistance
Enzymes
Fatty acids
Genes
Life Sciences
MAP kinase
Melanoma
Metabolism
News & Views
news-and-views
Oxidation
Oxidation resistance
Ribonucleic acid
RNA
Roles
Stem Cells
Transfer RNA
Translation
tRNA Val
Tumors
Valine
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Zusammenfassung:Aminoacyl-tRNA synthetases can promote or suppress cancer progression by regulating codon-dependent translation. A study now shows that valine aminoacyl-tRNA synthetase (VARS) promotes therapeutic resistance of melanoma to MAPK pathway inhibitors by enhancing translation of valine-enriched genes, including the fatty acid oxidation gene HADH .
ISSN:1465-7392
1476-4679
1476-4679
DOI:10.1038/s41556-024-01430-x