Nesfatin-1 mitigates calcific aortic valve disease via suppressing ferroptosis mediated by GSH/GPX4 and ZIP8/SOD2 axes

Calcific aortic valve disease (CAVD) predominantly affects the elderly and currently lacks effective medical treatments. Nesfatin-1, a peptide derived from the cleavage of Nucleobindin 2, has been implicated in various calcification processes, both physiological and pathological. This study explores...

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Veröffentlicht in:	Free radical biology & medicine 2024-09, Vol.222, p.149-164
Hauptverfasser:	Wang, Song, Gu, Jiaxi, Bian, Jinhui, He, Yuqiu, Xu, Xiufan, Wang, Chen, Li, Geng, Zhang, Hui, Ni, Buqing, Chen, Si, Shao, Yongfeng, Jiang, Yefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aortic valve interstitial cells Calcific aortic valve disease Ferroptosis Nesfatin-1 SOD2 ZIP8
Online-Zugang:	Volltext
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