Dendritic cells loaded with allogeneic tumour cell lysate plus best supportive care versus best supportive care alone in patients with pleural mesothelioma as maintenance therapy after chemotherapy (DENIM): a multicentre, open-label, randomised, phase 2/3 study

Dendritic cell immunotherapy has proven to be safe and induces an immune response in humans. We aimed to establish the efficacy of dendritic cells loaded with allogeneic tumour cell lysate (MesoPher, Amphera BV, 's-Hertogenbosch, Netherlands) as maintenance therapy in patients with pleural meso...

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Veröffentlicht in:	The lancet oncology 2024-07, Vol.25 (7), p.865-878
Hauptverfasser:	Aerts, Joachim G, Belderbos, Robert, Baas, Paul, Scherpereel, Arnaud, Bezemer, Koen, Enninga, Ilona, Meijer, Rob, Willemsen, Marcella, Berardi, Rossana, Fennell, Dean, Kerstens, Rene, Cornelissen, Robin, van Meerbeeck, Jan P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adverse events Aged Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer therapies Carboplatin Carboplatin - administration & dosage Chemotherapy Cisplatin Cisplatin - administration & dosage Committees COVID-19 Dendritic cells Dendritic Cells - immunology Dendritic Cells - transplantation Dyspnea Erythema Female Histology Humans Immune checkpoint Immunotherapy Investigations Leukapheresis Lymphocytes Maintenance Chemotherapy Male Mesothelioma Mesothelioma - drug therapy Mesothelioma - immunology Mesothelioma - mortality Mesothelioma - pathology Mesothelioma - therapy Mesothelioma, Malignant - drug therapy Mesothelioma, Malignant - pathology Mesothelioma, Malignant - therapy Middle Aged Pandemics Pemetrexed - administration & dosage Pleural Neoplasms - drug therapy Pleural Neoplasms - immunology Pleural Neoplasms - mortality Pleural Neoplasms - pathology Pleural Neoplasms - therapy Respiration Tumors
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