LKB1 inhibits telomerase activity resulting in cellular senescence through histone lactylation in lung adenocarcinoma

Despite the confirmed role of LKB1 in suppressing lung cancer progression, its precise effect on cellular senescence is unknown. The aim of this research was to clarify the role and mechanism of LKB1 in restraining telomerase activity in lung adenocarcinoma. The results showed that LKB1 induced cell...

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Veröffentlicht in:	Cancer letters 2024-07, Vol.595, p.217025, Article 217025
Hauptverfasser:	Liu, Mingdi, Gu, Liting, Zhang, Yuning, Li, Yunkuo, Zhang, Lihong, Xin, Ying, Wang, Yishu, Xu, Zhi-Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Histone lactylation LKB1 Lung adenocarcinoma Sp1 Telomerase
Online-Zugang:	Volltext
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