LRRK2 Kinase Inhibitor PF-06447475 Protects Drosophila melanogaster against Paraquat-Induced Locomotor Impairment, Life Span Reduction, and Oxidative Stress

Parkinson’s disease (PD) is a complex multifactorial progressive neurodegenerative disease characterized by locomotor alteration due to the specific deterioration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNpc). Mounting evidence shows that human LRRK2 (hLRRK2) kinase...

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Veröffentlicht in:	Neurochemical research 2024-09, Vol.49 (9), p.2440-2452
Hauptverfasser:	Quintero-Espinosa, Diana A., Jimenez-Del-Rio, Marlene, Velez-Pardo, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Dopamine receptors Drosophila melanogaster Drosophila Proteins - antagonists & inhibitors Drosophila Proteins - metabolism Evolutionary conservation Female Fruit flies Herbicides - toxicity Insects Kinases Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - antagonists & inhibitors Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - metabolism Life span Lipid peroxidation Lipids Locomotion - drug effects Locomotor activity Longevity - drug effects LRRK2 protein Movement disorders Neurochemistry Neurodegenerative diseases Neurology Neurosciences Original Paper Oxidative stress Oxidative Stress - drug effects Paraquat Paraquat - toxicity Parkinson's disease Peroxidation Protein Kinase Inhibitors - pharmacology Redox properties Substantia nigra Therapeutic targets
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