Molecular mechanisms involved in therapeutic effects of natural compounds against cisplatin-induced cardiotoxicity: a review
Cisplatin is a widely used chemotherapeutic agent for the treatment of various cancers. However, the clinical use of cisplatin is limited by its cardiotoxic side effects. The primary mechanisms implicated in this cardiotoxicity include mitochondrial dysfunction, oxidative stress, inflammation, and a...
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| creator | Hesari, Mahvash Mohammadi, Pantea Moradi, Mojtaba Shackebaei, Dareuosh Yarmohammadi, Fatemeh |
| description | Cisplatin is a widely used chemotherapeutic agent for the treatment of various cancers. However, the clinical use of cisplatin is limited by its cardiotoxic side effects. The primary mechanisms implicated in this cardiotoxicity include mitochondrial dysfunction, oxidative stress, inflammation, and apoptotic. Numerous natural compounds (NCs) have been introduced as promising protective factors against cisplatin-mediated cardiac damage. The current review summarized the potential of various NCs as cardioprotective agents at the molecular levels. These compounds exhibited potent antioxidant and anti-inflammatory effects by interaction with the PI3K/AKT, AMPK, Nrf2, NF-κB, and NLRP3/caspase-1/GSDMD pathways. Generally, the modulation of these signaling pathways by NCs represents a promising strategy for improving the therapeutic index of cisplatin by reducing its cardiac side effects. |
| doi_str_mv | 10.1007/s00210-024-03207-3 |
| format | Article |
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Generally, the modulation of these signaling pathways by NCs represents a promising strategy for improving the therapeutic index of cisplatin by reducing its cardiac side effects.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>Acids</subject><subject>AKT protein</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Apoptosis</subject><subject>Archives & records</subject><subject>Biological Products - pharmacology</subject><subject>Biological Products - therapeutic use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cardiotonic Agents - pharmacology</subject><subject>Cardiotonic Agents - therapeutic use</subject><subject>Cardiotoxicity</subject><subject>Cardiotoxicity - prevention & control</subject><subject>Caspase-1</subject><subject>Cisplatin</subject><subject>Cisplatin - adverse effects</subject><subject>Cisplatin - toxicity</subject><subject>Enzymes</subject><subject>Heart</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Kinases</subject><subject>Molecular modelling</subject><subject>Morphine</subject><subject>Neurosciences</subject><subject>NF-κB protein</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Pharmacology</subject><subject>Pharmacology/Toxicology</subject><subject>Proteins</subject><subject>Review</subject><subject>Side effects</subject><subject>Signal Transduction - drug effects</subject><subject>Tumor necrosis factor-TNF</subject><issn>0028-1298</issn><issn>1432-1912</issn><issn>1432-1912</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1rFTEUhoMo9rb6B1xIwI2b0ZPk5s6MOylqhYobXYfT5EybMpOM-bi14I839VYFF64SOM_75pCHsWcCXgmA_nUGkAI6kNsOlIS-Uw_YRmyV7MQo5EO2afOhE3IcjthxztcAsBNaP2ZHahg0KNht2I9PcSZbZ0x8IXuFweclcx_2cd6TaxderijhSrV4y2mayJbM48QDlppw5jYua6zBZY6X6EMu3Pq8zlh86Hxw1bYWi8n5WOJ3b325fcORJ9p7unnCHk04Z3p6f56wr-_ffTk9684_f_h4-va8s1LvSqcJEZ2Qdti5STonFbbloVf9OKkLqa1UVsNkUeutlUKSU0qrllIaBuFQnbCXh941xW-VcjGLz5bmGQPFmk37CT32w9Drhr74B72ONYW2nVFCin4UI6hGyQNlU8w50WTW5BdMt0aAuXNjDm5Mc2N-uTF3oef31fViIfcn8ltGA9QByG0ULin9ffs_tT8By_ubuQ</recordid><startdate>20241101</startdate><enddate>20241101</enddate><creator>Hesari, Mahvash</creator><creator>Mohammadi, Pantea</creator><creator>Moradi, Mojtaba</creator><creator>Shackebaei, Dareuosh</creator><creator>Yarmohammadi, Fatemeh</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5919-9750</orcidid><orcidid>https://orcid.org/0000-0002-0552-8766</orcidid><orcidid>https://orcid.org/0000-0002-0015-4320</orcidid><orcidid>https://orcid.org/0000-0001-5884-0844</orcidid><orcidid>https://orcid.org/0000-0001-8774-4835</orcidid></search><sort><creationdate>20241101</creationdate><title>Molecular mechanisms involved in therapeutic effects of natural compounds against cisplatin-induced cardiotoxicity: a review</title><author>Hesari, Mahvash ; 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| subjects | 1-Phosphatidylinositol 3-kinase Acids AKT protein Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antineoplastic Agents - adverse effects Antioxidants Antioxidants - pharmacology Antioxidants - therapeutic use Apoptosis Archives & records Biological Products - pharmacology Biological Products - therapeutic use Biomedical and Life Sciences Biomedicine Cardiotonic Agents - pharmacology Cardiotonic Agents - therapeutic use Cardiotoxicity Cardiotoxicity - prevention & control Caspase-1 Cisplatin Cisplatin - adverse effects Cisplatin - toxicity Enzymes Heart Humans Inflammation Kinases Molecular modelling Morphine Neurosciences NF-κB protein Oxidative stress Oxidative Stress - drug effects Pharmacology Pharmacology/Toxicology Proteins Review Side effects Signal Transduction - drug effects Tumor necrosis factor-TNF |
| title | Molecular mechanisms involved in therapeutic effects of natural compounds against cisplatin-induced cardiotoxicity: a review |
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