Unraveling the intriguing interplay: Exploring the role of lncRNAs in caspase‐independent cell death

Cell death plays a crucial role in various physiological and pathological processes. Until recently, programmed cell death was mainly attributed to caspase‐dependent apoptosis. However, emerging evidence suggests that caspase‐independent cell death (CICD) mechanisms also contribute significantly to...

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Veröffentlicht in:Wiley interdisciplinary reviews. RNA 2024-05, Vol.15 (3), p.e1862-n/a
Hauptverfasser: Ciftci, Yusuf Cem, Vatansever, İpek Erdoğan, Akgül, Bünyamin
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creator Ciftci, Yusuf Cem
Vatansever, İpek Erdoğan
Akgül, Bünyamin
description Cell death plays a crucial role in various physiological and pathological processes. Until recently, programmed cell death was mainly attributed to caspase‐dependent apoptosis. However, emerging evidence suggests that caspase‐independent cell death (CICD) mechanisms also contribute significantly to cellular demise. We and others have reported and functionally characterized numerous long noncoding RNAs (lncRNAs) that modulate caspase‐dependent apoptotic pathways potentially in a pathway‐dependent manner. However, the interplay between lncRNAs and CICD pathways has not been comprehensively documented. One major reason for this is that most CICD pathways have been recently discovered with some being partially characterized at the molecular level. In this review, we discuss the emerging evidence that implicates specific lncRNAs in the regulation and execution of CICD. We summarize the diverse mechanisms through which lncRNAs modulate different forms of CICD, including ferroptosis, necroptosis, cuproptosis, and others. Furthermore, we highlight the intricate regulatory networks involving lncRNAs, protein‐coding genes, and signaling pathways that orchestrate CICD in health and disease. Understanding the molecular mechanisms and functional implications of lncRNAs in CICD may unravel novel therapeutic targets and diagnostic tools for various diseases, paving the way for innovative strategies in disease management and personalized medicine. This article is categorized under: RNA in Disease and Development > RNA in Disease Interplay between lncRNAs and caspase‐independent cell death.
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source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Animals
Apoptosis
Apoptosis - genetics
Caspase
Caspases - genetics
Caspases - metabolism
caspase‐independent cell death
Cell death
Cell Death - genetics
Disease
Ferroptosis
Humans
lncRNA
Medical innovations
Molecular modelling
Necroptosis
Non-coding RNA
Precision medicine
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Signal Transduction
Therapeutic targets
title Unraveling the intriguing interplay: Exploring the role of lncRNAs in caspase‐independent cell death
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