Unraveling the intriguing interplay: Exploring the role of lncRNAs in caspase‐independent cell death
Cell death plays a crucial role in various physiological and pathological processes. Until recently, programmed cell death was mainly attributed to caspase‐dependent apoptosis. However, emerging evidence suggests that caspase‐independent cell death (CICD) mechanisms also contribute significantly to...
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description | Cell death plays a crucial role in various physiological and pathological processes. Until recently, programmed cell death was mainly attributed to caspase‐dependent apoptosis. However, emerging evidence suggests that caspase‐independent cell death (CICD) mechanisms also contribute significantly to cellular demise. We and others have reported and functionally characterized numerous long noncoding RNAs (lncRNAs) that modulate caspase‐dependent apoptotic pathways potentially in a pathway‐dependent manner. However, the interplay between lncRNAs and CICD pathways has not been comprehensively documented. One major reason for this is that most CICD pathways have been recently discovered with some being partially characterized at the molecular level. In this review, we discuss the emerging evidence that implicates specific lncRNAs in the regulation and execution of CICD. We summarize the diverse mechanisms through which lncRNAs modulate different forms of CICD, including ferroptosis, necroptosis, cuproptosis, and others. Furthermore, we highlight the intricate regulatory networks involving lncRNAs, protein‐coding genes, and signaling pathways that orchestrate CICD in health and disease. Understanding the molecular mechanisms and functional implications of lncRNAs in CICD may unravel novel therapeutic targets and diagnostic tools for various diseases, paving the way for innovative strategies in disease management and personalized medicine.
This article is categorized under:
RNA in Disease and Development > RNA in Disease
Interplay between lncRNAs and caspase‐independent cell death. |
doi_str_mv | 10.1002/wrna.1862 |
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This article is categorized under:
RNA in Disease and Development > RNA in Disease
Interplay between lncRNAs and caspase‐independent cell death.</description><identifier>ISSN: 1757-7004</identifier><identifier>ISSN: 1757-7012</identifier><identifier>EISSN: 1757-7012</identifier><identifier>DOI: 10.1002/wrna.1862</identifier><identifier>PMID: 38837618</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Animals ; Apoptosis ; Apoptosis - genetics ; Caspase ; Caspases - genetics ; Caspases - metabolism ; caspase‐independent cell death ; Cell death ; Cell Death - genetics ; Disease ; Ferroptosis ; Humans ; lncRNA ; Medical innovations ; Molecular modelling ; Necroptosis ; Non-coding RNA ; Precision medicine ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; Signal Transduction ; Therapeutic targets</subject><ispartof>Wiley interdisciplinary reviews. RNA, 2024-05, Vol.15 (3), p.e1862-n/a</ispartof><rights>2024 The Author(s). published by Wiley Periodicals LLC.</rights><rights>2024 The Author(s). WIREs RNA published by Wiley Periodicals LLC.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2782-4705a63d20f1744b3ef1a86dff27cef3a2bb265ce435189325af500f0fc2f1243</cites><orcidid>0000-0001-6415-7654 ; 0000-0001-9877-9689</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fwrna.1862$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fwrna.1862$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38837618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ciftci, Yusuf Cem</creatorcontrib><creatorcontrib>Vatansever, İpek Erdoğan</creatorcontrib><creatorcontrib>Akgül, Bünyamin</creatorcontrib><title>Unraveling the intriguing interplay: Exploring the role of lncRNAs in caspase‐independent cell death</title><title>Wiley interdisciplinary reviews. RNA</title><addtitle>Wiley Interdiscip Rev RNA</addtitle><description>Cell death plays a crucial role in various physiological and pathological processes. Until recently, programmed cell death was mainly attributed to caspase‐dependent apoptosis. However, emerging evidence suggests that caspase‐independent cell death (CICD) mechanisms also contribute significantly to cellular demise. We and others have reported and functionally characterized numerous long noncoding RNAs (lncRNAs) that modulate caspase‐dependent apoptotic pathways potentially in a pathway‐dependent manner. However, the interplay between lncRNAs and CICD pathways has not been comprehensively documented. One major reason for this is that most CICD pathways have been recently discovered with some being partially characterized at the molecular level. In this review, we discuss the emerging evidence that implicates specific lncRNAs in the regulation and execution of CICD. We summarize the diverse mechanisms through which lncRNAs modulate different forms of CICD, including ferroptosis, necroptosis, cuproptosis, and others. Furthermore, we highlight the intricate regulatory networks involving lncRNAs, protein‐coding genes, and signaling pathways that orchestrate CICD in health and disease. Understanding the molecular mechanisms and functional implications of lncRNAs in CICD may unravel novel therapeutic targets and diagnostic tools for various diseases, paving the way for innovative strategies in disease management and personalized medicine.
This article is categorized under:
RNA in Disease and Development > RNA in Disease
Interplay between lncRNAs and caspase‐independent cell death.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - genetics</subject><subject>Caspase</subject><subject>Caspases - genetics</subject><subject>Caspases - metabolism</subject><subject>caspase‐independent cell death</subject><subject>Cell death</subject><subject>Cell Death - genetics</subject><subject>Disease</subject><subject>Ferroptosis</subject><subject>Humans</subject><subject>lncRNA</subject><subject>Medical innovations</subject><subject>Molecular modelling</subject><subject>Necroptosis</subject><subject>Non-coding RNA</subject><subject>Precision medicine</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>Signal Transduction</subject><subject>Therapeutic targets</subject><issn>1757-7004</issn><issn>1757-7012</issn><issn>1757-7012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp10E1LwzAYB_AgihtzB7-AFLzooVtemqbzNsZ8gaEgDo8la59sHVlbk9a5mx_Bz-gnMXUvB8Eckifw48_DH6FzgnsEY9pfm1z2SBTSI9QmggtfYEKPDzMOWqhr7RK7E2AqCDlFLRZFTIQkaiM1zY18B53lc69agJfllcnmdfN1I5hSy82NN_4odWH2xhQavEJ5Ok-eH4fWQS-RtpQWvj-_sjyFEtyVV14CWnspyGpxhk6U1Ba6u7eDprfjl9G9P3m6exgNJ35CRUT9QGAuQ5ZSrIgIghkDRWQUpkpRkYBiks5mNOQJBIyTaMAol4pjrLBKqCI0YB10tc0tTfFWg63iVWabNWQORW1jhkNOBR8E2NHLP3RZ1K5L3ShBCYs4DZ263qrEFNYaUHFpspU0m5jguOk_bvqPm_6dvdgl1rMVpAe5b9uB_hasMw2b_5PiV9frb-QPmM6QRw</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Ciftci, Yusuf Cem</creator><creator>Vatansever, İpek Erdoğan</creator><creator>Akgül, Bünyamin</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6415-7654</orcidid><orcidid>https://orcid.org/0000-0001-9877-9689</orcidid></search><sort><creationdate>202405</creationdate><title>Unraveling the intriguing interplay: Exploring the role of lncRNAs in caspase‐independent cell death</title><author>Ciftci, Yusuf Cem ; Vatansever, İpek Erdoğan ; Akgül, Bünyamin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2782-4705a63d20f1744b3ef1a86dff27cef3a2bb265ce435189325af500f0fc2f1243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - genetics</topic><topic>Caspase</topic><topic>Caspases - genetics</topic><topic>Caspases - metabolism</topic><topic>caspase‐independent cell death</topic><topic>Cell death</topic><topic>Cell Death - genetics</topic><topic>Disease</topic><topic>Ferroptosis</topic><topic>Humans</topic><topic>lncRNA</topic><topic>Medical innovations</topic><topic>Molecular modelling</topic><topic>Necroptosis</topic><topic>Non-coding RNA</topic><topic>Precision medicine</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>Signal Transduction</topic><topic>Therapeutic targets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ciftci, Yusuf Cem</creatorcontrib><creatorcontrib>Vatansever, İpek Erdoğan</creatorcontrib><creatorcontrib>Akgül, Bünyamin</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Wiley interdisciplinary reviews. RNA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ciftci, Yusuf Cem</au><au>Vatansever, İpek Erdoğan</au><au>Akgül, Bünyamin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unraveling the intriguing interplay: Exploring the role of lncRNAs in caspase‐independent cell death</atitle><jtitle>Wiley interdisciplinary reviews. RNA</jtitle><addtitle>Wiley Interdiscip Rev RNA</addtitle><date>2024-05</date><risdate>2024</risdate><volume>15</volume><issue>3</issue><spage>e1862</spage><epage>n/a</epage><pages>e1862-n/a</pages><issn>1757-7004</issn><issn>1757-7012</issn><eissn>1757-7012</eissn><abstract>Cell death plays a crucial role in various physiological and pathological processes. Until recently, programmed cell death was mainly attributed to caspase‐dependent apoptosis. However, emerging evidence suggests that caspase‐independent cell death (CICD) mechanisms also contribute significantly to cellular demise. We and others have reported and functionally characterized numerous long noncoding RNAs (lncRNAs) that modulate caspase‐dependent apoptotic pathways potentially in a pathway‐dependent manner. However, the interplay between lncRNAs and CICD pathways has not been comprehensively documented. One major reason for this is that most CICD pathways have been recently discovered with some being partially characterized at the molecular level. In this review, we discuss the emerging evidence that implicates specific lncRNAs in the regulation and execution of CICD. We summarize the diverse mechanisms through which lncRNAs modulate different forms of CICD, including ferroptosis, necroptosis, cuproptosis, and others. Furthermore, we highlight the intricate regulatory networks involving lncRNAs, protein‐coding genes, and signaling pathways that orchestrate CICD in health and disease. Understanding the molecular mechanisms and functional implications of lncRNAs in CICD may unravel novel therapeutic targets and diagnostic tools for various diseases, paving the way for innovative strategies in disease management and personalized medicine.
This article is categorized under:
RNA in Disease and Development > RNA in Disease
Interplay between lncRNAs and caspase‐independent cell death.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>38837618</pmid><doi>10.1002/wrna.1862</doi><tpages>24</tpages><orcidid>https://orcid.org/0000-0001-6415-7654</orcidid><orcidid>https://orcid.org/0000-0001-9877-9689</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Animals Apoptosis Apoptosis - genetics Caspase Caspases - genetics Caspases - metabolism caspase‐independent cell death Cell death Cell Death - genetics Disease Ferroptosis Humans lncRNA Medical innovations Molecular modelling Necroptosis Non-coding RNA Precision medicine RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Signal Transduction Therapeutic targets |
title | Unraveling the intriguing interplay: Exploring the role of lncRNAs in caspase‐independent cell death |
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