Role of the PARP1/NF-κB Pathway in DNA Damage and Apoptosis of TK6 Cells Induced by Hydroquinone

Hydroquinone­(HQ) is a widely used industrial raw material and is a topical lightening product found in over-the-counter products. However, inappropriate exposure to HQ can pose certain health hazards. This study aims to explore the mechanisms of DNA damage and cell apoptosis caused by HQ, with a fo...

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Veröffentlicht in:	Chemical research in toxicology 2024-07, Vol.37 (7), p.1187-1198
Hauptverfasser:	Wu, Haipeng, Tang, Huan, Zou, Xiangli, Huang, Qihao, Wang, Shimei, Sun, Mingzhu, Ye, Zhongming, Wang, Huanhuan, Wu, Yao, Sun, Lei, Chen, Yuting, Tang, Huanwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Cell Line Cell Survival - drug effects DNA Damage - drug effects Dose-Response Relationship, Drug Humans Hydroquinones - pharmacology NF-kappa B - metabolism Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors Poly (ADP-Ribose) Polymerase-1 - metabolism Signal Transduction - drug effects
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