Design, synthesis and antiproliferative activity of raloxifene/histone deacetylase inhibitor hybrids in breast cancer

Antiestrogen/histone deacetylase inhibitor (HDACi) hybrids were designed by merging structures of raloxifene with suberoylanilide hydroxamic acid, incorporating the HDACi unit into the phenolic ring of the antiestrogen. These hybrids were synthesized with a range of HDACi chain lengths and assessed...

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Veröffentlicht in:	European journal of medicinal chemistry 2024-08, Vol.274, p.116533, Article 116533
Hauptverfasser:	Wang, Yufei, Sauvage, Madline, Diennet, Marine, Weber, Sandra, Mader, Sylvie, Gleason, James L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cell Line, Tumor Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug Design Drug Screening Assays, Antitumor Female Histone Deacetylase Inhibitors - chemical synthesis Histone Deacetylase Inhibitors - chemistry Histone Deacetylase Inhibitors - pharmacology Humans Molecular Structure Raloxifene Hydrochloride - chemical synthesis Raloxifene Hydrochloride - chemistry Raloxifene Hydrochloride - pharmacology Structure-Activity Relationship
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