Di- and tri-methylation of histone H3K36 play distinct roles in DNA double-strand break repair

Histone H3 Lys36 (H3K36) methylation and its associated modifiers are crucial for DNA double-strand break (DSB) repair, but the mechanism governing whether and how different H3K36 methylation forms impact repair pathways is unclear. Here, we unveil the distinct roles of H3K36 dimethylation (H3K36me2...

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Veröffentlicht in:	Science China. Life sciences 2024-06, Vol.67 (6), p.1089-1105
Hauptverfasser:	Chen, Runfa, Zhao, Meng-Jie, Li, Yu-Min, Liu, Ao-Hui, Wang, Ru-Xin, Mei, Yu-Chao, Chen, Xuefeng, Du, Hai-Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Chromatin Chromatin - genetics Chromatin - metabolism Cover Article DNA Breaks, Double-Stranded DNA damage DNA End-Joining Repair DNA methylation DNA Repair DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Double-strand break repair Histone H3 Histones Histones - metabolism Homologous Recombination Humans Ku Autoantigen - genetics Ku Autoantigen - metabolism Life Sciences Methylation Non-homologous end joining Replication Protein A - genetics Replication Protein A - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Yeast
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