Inhibition mechanisms of CRISPR-Cas9 by AcrIIA25.1 and AcrIIA32

In the ongoing arms race between bacteria and bacteriophages, bacteriophages have evolved anti-CRISPR proteins to counteract bacterial CRISPR-Cas systems. Recently, AcrIIA25.1 and AcrIIA32 have been found to effectively inhibit the activity of SpyCas9 both in bacterial and human cells. However, thei...

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Veröffentlicht in:	Science China. Life sciences 2024-09, Vol.67 (9), p.1781-1791
Hauptverfasser:	Zheng, Jianlin, Zhu, Yuwei, Huang, Tengjin, Gao, Wenbo, He, Jiale, Huang, Zhiwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Cover Article CRISPR Electron microscopy Life Sciences Molecular modelling Phages Unwinding
Online-Zugang:	Volltext
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