The clinical course of individuals with 22q11.2 deletion syndrome converting to psychotic disorders: a long-term retrospective follow-up
Objectives This retrospective study aims to investigate the evolution and clinical course of psychotic disorders from three large international cohorts of individuals with 22q11.2 deletion syndrome (22q11.2DS) (Tel Aviv, Philadelphia, and Geneva). Methods We followed 118 individuals with 22q11.2DS f...
Gespeichert in:
| Veröffentlicht in: | European child & adolescent psychiatry 2024-12, Vol.33 (12), p.4371-4379 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4379 |
|---|---|
| container_issue | 12 |
| container_start_page | 4371 |
| container_title | European child & adolescent psychiatry |
| container_volume | 33 |
| creator | Kulikova, Katerina Schneider, Maude McDonald McGinn, Donna M. Dar, Shira Taler, Michal Schwartz-Lifshitz, Maya Eliez, Stephan Gur, Raquel E. Gothelf, Doron |
| description | Objectives
This retrospective study aims to investigate the evolution and clinical course of psychotic disorders from three large international cohorts of individuals with 22q11.2 deletion syndrome (22q11.2DS) (Tel Aviv, Philadelphia, and Geneva).
Methods
We followed 118 individuals with 22q11.2DS from several years before the onset to several years after the onset of psychotic disorders. Data from structured baseline assessment of psychiatric disorders, symptoms of prodrome, indicators and types of psychotic disorders were collected. Additionally, cognitive evaluation was conducted using the age-appropriate Wechsler Intelligence Scale. Electronic medical records were reviewed for medication usage, occupational status, living situation, and psychiatric hospitalizations.
Results
At baseline evaluation, the most common psychiatric disorders were anxiety disorder (80%) and attention/deficit hyperactivity disorder (50%). The age of onset of prodromal symptoms and conversion to psychotic disorders were 18.6 ± 6.8 and 20.3 ± 7.2, respectively. The most common prodromal symptoms were exacerbation of anxiety symptoms and social isolation. Of the psychotic disorders, schizophrenia was the most common, occurring in 49% of cases. History of at least one psychiatric hospitalization was present in 43% of participants, and the number of psychiatric hospitalizations was 2.1 ± 1.4. Compared to the normalized chart, IQ scores in our cohort were lower after vs. before conversion to psychosis. Following conversion there was a decrease in the use of stimulants and antidepressants and an increase in antipsychotics use, and most individuals with 22q11.2DS were unemployed and lived with their parents.
Conclusions
Our results indicate that 22q11.2DS psychosis is like non-22q11.2DS in its course, symptoms, and cognitive and functional impairments. |
| doi_str_mv | 10.1007/s00787-024-02469-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3064921112</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3064921112</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-ee82756aadcd10f2f0b7ef0b79d94a252d51440ac331b3899a918450df3c32eb3</originalsourceid><addsrcrecordid>eNp9kc2OFCEUhStG44yjL-DCkLhxw8hfVYE7M_EvmcTNmLgjNNzqZkJBDVA96TfwsaXtURMXLriQ8J1zuZyue0nJJSVkfFtakSMmTBzXoLB61J1TwXtMh_7743YmVGIp2XjWPSvllhDaK8KedmdcSi7kyM-7Hzc7QDb46K0JyKY1F0BpQj46v_duNaGge193iLE7Si8ZchCg-hRROUSX09zUKe4hVx-3qCa0lIPdpeotcr6k7CCXd8igkOIWV8gzylBzKgvY6veAphRCusfr8rx7MrVm8OJhv-i-ffxwc_UZX3_99OXq_TW2rB8qBmjj9IMxzjpKJjaRzQjHopwShvXM9VQIYizndMOlUkZRKXriJm45gw2_6N6cfJec7lYoVc--WAjBREhr0ZwMQjFKKWvo63_Q2_Y_sb1OcyqIHIngY6PYibJtrJJh0kv2s8kHTYk-5qRPOemWkf6Vk1ZN9OrBet3M4P5IfgfTAH4CSruKW8h_e__H9ifjPJ97</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3140870437</pqid></control><display><type>article</type><title>The clinical course of individuals with 22q11.2 deletion syndrome converting to psychotic disorders: a long-term retrospective follow-up</title><source>MEDLINE</source><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>Springer Nature - Complete Springer Journals</source><creator>Kulikova, Katerina ; Schneider, Maude ; McDonald McGinn, Donna M. ; Dar, Shira ; Taler, Michal ; Schwartz-Lifshitz, Maya ; Eliez, Stephan ; Gur, Raquel E. ; Gothelf, Doron</creator><creatorcontrib>Kulikova, Katerina ; Schneider, Maude ; McDonald McGinn, Donna M. ; Dar, Shira ; Taler, Michal ; Schwartz-Lifshitz, Maya ; Eliez, Stephan ; Gur, Raquel E. ; Gothelf, Doron</creatorcontrib><description>Objectives
This retrospective study aims to investigate the evolution and clinical course of psychotic disorders from three large international cohorts of individuals with 22q11.2 deletion syndrome (22q11.2DS) (Tel Aviv, Philadelphia, and Geneva).
Methods
We followed 118 individuals with 22q11.2DS from several years before the onset to several years after the onset of psychotic disorders. Data from structured baseline assessment of psychiatric disorders, symptoms of prodrome, indicators and types of psychotic disorders were collected. Additionally, cognitive evaluation was conducted using the age-appropriate Wechsler Intelligence Scale. Electronic medical records were reviewed for medication usage, occupational status, living situation, and psychiatric hospitalizations.
Results
At baseline evaluation, the most common psychiatric disorders were anxiety disorder (80%) and attention/deficit hyperactivity disorder (50%). The age of onset of prodromal symptoms and conversion to psychotic disorders were 18.6 ± 6.8 and 20.3 ± 7.2, respectively. The most common prodromal symptoms were exacerbation of anxiety symptoms and social isolation. Of the psychotic disorders, schizophrenia was the most common, occurring in 49% of cases. History of at least one psychiatric hospitalization was present in 43% of participants, and the number of psychiatric hospitalizations was 2.1 ± 1.4. Compared to the normalized chart, IQ scores in our cohort were lower after vs. before conversion to psychosis. Following conversion there was a decrease in the use of stimulants and antidepressants and an increase in antipsychotics use, and most individuals with 22q11.2DS were unemployed and lived with their parents.
Conclusions
Our results indicate that 22q11.2DS psychosis is like non-22q11.2DS in its course, symptoms, and cognitive and functional impairments.</description><identifier>ISSN: 1018-8827</identifier><identifier>ISSN: 1435-165X</identifier><identifier>EISSN: 1435-165X</identifier><identifier>DOI: 10.1007/s00787-024-02469-9</identifier><identifier>PMID: 38834873</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Age of onset ; Antidepressants ; Antipsychotics ; Anxiety disorders ; Attention deficit hyperactivity disorder ; Child ; Child and Adolescent Psychiatry ; Computerized medical records ; Conversion disorder ; DiGeorge Syndrome - complications ; DiGeorge Syndrome - psychology ; Disease Progression ; Drugs ; Electronic medical records ; Female ; Follow-Up Studies ; Hospitalization ; Humans ; Hyperactivity ; Intelligence tests ; Male ; Medical records ; Medicine ; Medicine & Public Health ; Mental disorders ; Occupational status ; Original Contribution ; Prodromal Symptoms ; Psychiatric hospitals ; Psychiatric symptoms ; Psychiatry ; Psychosis ; Psychotic Disorders ; Psychotic symptoms ; Psychotropic drugs ; Retrospective Studies ; Schizophrenia ; Social anxiety ; Social interactions ; Social isolation ; Stimulants ; Symptoms ; Unemployed people ; Young Adult</subject><ispartof>European child & adolescent psychiatry, 2024-12, Vol.33 (12), p.4371-4379</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2024 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>Copyright Springer Nature B.V. Dec 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-ee82756aadcd10f2f0b7ef0b79d94a252d51440ac331b3899a918450df3c32eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00787-024-02469-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00787-024-02469-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,30978,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38834873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kulikova, Katerina</creatorcontrib><creatorcontrib>Schneider, Maude</creatorcontrib><creatorcontrib>McDonald McGinn, Donna M.</creatorcontrib><creatorcontrib>Dar, Shira</creatorcontrib><creatorcontrib>Taler, Michal</creatorcontrib><creatorcontrib>Schwartz-Lifshitz, Maya</creatorcontrib><creatorcontrib>Eliez, Stephan</creatorcontrib><creatorcontrib>Gur, Raquel E.</creatorcontrib><creatorcontrib>Gothelf, Doron</creatorcontrib><title>The clinical course of individuals with 22q11.2 deletion syndrome converting to psychotic disorders: a long-term retrospective follow-up</title><title>European child & adolescent psychiatry</title><addtitle>Eur Child Adolesc Psychiatry</addtitle><addtitle>Eur Child Adolesc Psychiatry</addtitle><description>Objectives
This retrospective study aims to investigate the evolution and clinical course of psychotic disorders from three large international cohorts of individuals with 22q11.2 deletion syndrome (22q11.2DS) (Tel Aviv, Philadelphia, and Geneva).
Methods
We followed 118 individuals with 22q11.2DS from several years before the onset to several years after the onset of psychotic disorders. Data from structured baseline assessment of psychiatric disorders, symptoms of prodrome, indicators and types of psychotic disorders were collected. Additionally, cognitive evaluation was conducted using the age-appropriate Wechsler Intelligence Scale. Electronic medical records were reviewed for medication usage, occupational status, living situation, and psychiatric hospitalizations.
Results
At baseline evaluation, the most common psychiatric disorders were anxiety disorder (80%) and attention/deficit hyperactivity disorder (50%). The age of onset of prodromal symptoms and conversion to psychotic disorders were 18.6 ± 6.8 and 20.3 ± 7.2, respectively. The most common prodromal symptoms were exacerbation of anxiety symptoms and social isolation. Of the psychotic disorders, schizophrenia was the most common, occurring in 49% of cases. History of at least one psychiatric hospitalization was present in 43% of participants, and the number of psychiatric hospitalizations was 2.1 ± 1.4. Compared to the normalized chart, IQ scores in our cohort were lower after vs. before conversion to psychosis. Following conversion there was a decrease in the use of stimulants and antidepressants and an increase in antipsychotics use, and most individuals with 22q11.2DS were unemployed and lived with their parents.
Conclusions
Our results indicate that 22q11.2DS psychosis is like non-22q11.2DS in its course, symptoms, and cognitive and functional impairments.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age of onset</subject><subject>Antidepressants</subject><subject>Antipsychotics</subject><subject>Anxiety disorders</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Child</subject><subject>Child and Adolescent Psychiatry</subject><subject>Computerized medical records</subject><subject>Conversion disorder</subject><subject>DiGeorge Syndrome - complications</subject><subject>DiGeorge Syndrome - psychology</subject><subject>Disease Progression</subject><subject>Drugs</subject><subject>Electronic medical records</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Hyperactivity</subject><subject>Intelligence tests</subject><subject>Male</subject><subject>Medical records</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental disorders</subject><subject>Occupational status</subject><subject>Original Contribution</subject><subject>Prodromal Symptoms</subject><subject>Psychiatric hospitals</subject><subject>Psychiatric symptoms</subject><subject>Psychiatry</subject><subject>Psychosis</subject><subject>Psychotic Disorders</subject><subject>Psychotic symptoms</subject><subject>Psychotropic drugs</subject><subject>Retrospective Studies</subject><subject>Schizophrenia</subject><subject>Social anxiety</subject><subject>Social interactions</subject><subject>Social isolation</subject><subject>Stimulants</subject><subject>Symptoms</subject><subject>Unemployed people</subject><subject>Young Adult</subject><issn>1018-8827</issn><issn>1435-165X</issn><issn>1435-165X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNp9kc2OFCEUhStG44yjL-DCkLhxw8hfVYE7M_EvmcTNmLgjNNzqZkJBDVA96TfwsaXtURMXLriQ8J1zuZyue0nJJSVkfFtakSMmTBzXoLB61J1TwXtMh_7743YmVGIp2XjWPSvllhDaK8KedmdcSi7kyM-7Hzc7QDb46K0JyKY1F0BpQj46v_duNaGge193iLE7Si8ZchCg-hRROUSX09zUKe4hVx-3qCa0lIPdpeotcr6k7CCXd8igkOIWV8gzylBzKgvY6veAphRCusfr8rx7MrVm8OJhv-i-ffxwc_UZX3_99OXq_TW2rB8qBmjj9IMxzjpKJjaRzQjHopwShvXM9VQIYizndMOlUkZRKXriJm45gw2_6N6cfJec7lYoVc--WAjBREhr0ZwMQjFKKWvo63_Q2_Y_sb1OcyqIHIngY6PYibJtrJJh0kv2s8kHTYk-5qRPOemWkf6Vk1ZN9OrBet3M4P5IfgfTAH4CSruKW8h_e__H9ifjPJ97</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Kulikova, Katerina</creator><creator>Schneider, Maude</creator><creator>McDonald McGinn, Donna M.</creator><creator>Dar, Shira</creator><creator>Taler, Michal</creator><creator>Schwartz-Lifshitz, Maya</creator><creator>Eliez, Stephan</creator><creator>Gur, Raquel E.</creator><creator>Gothelf, Doron</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20241201</creationdate><title>The clinical course of individuals with 22q11.2 deletion syndrome converting to psychotic disorders: a long-term retrospective follow-up</title><author>Kulikova, Katerina ; Schneider, Maude ; McDonald McGinn, Donna M. ; Dar, Shira ; Taler, Michal ; Schwartz-Lifshitz, Maya ; Eliez, Stephan ; Gur, Raquel E. ; Gothelf, Doron</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-ee82756aadcd10f2f0b7ef0b79d94a252d51440ac331b3899a918450df3c32eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age of onset</topic><topic>Antidepressants</topic><topic>Antipsychotics</topic><topic>Anxiety disorders</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Child</topic><topic>Child and Adolescent Psychiatry</topic><topic>Computerized medical records</topic><topic>Conversion disorder</topic><topic>DiGeorge Syndrome - complications</topic><topic>DiGeorge Syndrome - psychology</topic><topic>Disease Progression</topic><topic>Drugs</topic><topic>Electronic medical records</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Hyperactivity</topic><topic>Intelligence tests</topic><topic>Male</topic><topic>Medical records</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental disorders</topic><topic>Occupational status</topic><topic>Original Contribution</topic><topic>Prodromal Symptoms</topic><topic>Psychiatric hospitals</topic><topic>Psychiatric symptoms</topic><topic>Psychiatry</topic><topic>Psychosis</topic><topic>Psychotic Disorders</topic><topic>Psychotic symptoms</topic><topic>Psychotropic drugs</topic><topic>Retrospective Studies</topic><topic>Schizophrenia</topic><topic>Social anxiety</topic><topic>Social interactions</topic><topic>Social isolation</topic><topic>Stimulants</topic><topic>Symptoms</topic><topic>Unemployed people</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kulikova, Katerina</creatorcontrib><creatorcontrib>Schneider, Maude</creatorcontrib><creatorcontrib>McDonald McGinn, Donna M.</creatorcontrib><creatorcontrib>Dar, Shira</creatorcontrib><creatorcontrib>Taler, Michal</creatorcontrib><creatorcontrib>Schwartz-Lifshitz, Maya</creatorcontrib><creatorcontrib>Eliez, Stephan</creatorcontrib><creatorcontrib>Gur, Raquel E.</creatorcontrib><creatorcontrib>Gothelf, Doron</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>European child & adolescent psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kulikova, Katerina</au><au>Schneider, Maude</au><au>McDonald McGinn, Donna M.</au><au>Dar, Shira</au><au>Taler, Michal</au><au>Schwartz-Lifshitz, Maya</au><au>Eliez, Stephan</au><au>Gur, Raquel E.</au><au>Gothelf, Doron</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The clinical course of individuals with 22q11.2 deletion syndrome converting to psychotic disorders: a long-term retrospective follow-up</atitle><jtitle>European child & adolescent psychiatry</jtitle><stitle>Eur Child Adolesc Psychiatry</stitle><addtitle>Eur Child Adolesc Psychiatry</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>33</volume><issue>12</issue><spage>4371</spage><epage>4379</epage><pages>4371-4379</pages><issn>1018-8827</issn><issn>1435-165X</issn><eissn>1435-165X</eissn><abstract>Objectives
This retrospective study aims to investigate the evolution and clinical course of psychotic disorders from three large international cohorts of individuals with 22q11.2 deletion syndrome (22q11.2DS) (Tel Aviv, Philadelphia, and Geneva).
Methods
We followed 118 individuals with 22q11.2DS from several years before the onset to several years after the onset of psychotic disorders. Data from structured baseline assessment of psychiatric disorders, symptoms of prodrome, indicators and types of psychotic disorders were collected. Additionally, cognitive evaluation was conducted using the age-appropriate Wechsler Intelligence Scale. Electronic medical records were reviewed for medication usage, occupational status, living situation, and psychiatric hospitalizations.
Results
At baseline evaluation, the most common psychiatric disorders were anxiety disorder (80%) and attention/deficit hyperactivity disorder (50%). The age of onset of prodromal symptoms and conversion to psychotic disorders were 18.6 ± 6.8 and 20.3 ± 7.2, respectively. The most common prodromal symptoms were exacerbation of anxiety symptoms and social isolation. Of the psychotic disorders, schizophrenia was the most common, occurring in 49% of cases. History of at least one psychiatric hospitalization was present in 43% of participants, and the number of psychiatric hospitalizations was 2.1 ± 1.4. Compared to the normalized chart, IQ scores in our cohort were lower after vs. before conversion to psychosis. Following conversion there was a decrease in the use of stimulants and antidepressants and an increase in antipsychotics use, and most individuals with 22q11.2DS were unemployed and lived with their parents.
Conclusions
Our results indicate that 22q11.2DS psychosis is like non-22q11.2DS in its course, symptoms, and cognitive and functional impairments.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38834873</pmid><doi>10.1007/s00787-024-02469-9</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1018-8827 |
| ispartof | European child & adolescent psychiatry, 2024-12, Vol.33 (12), p.4371-4379 |
| issn | 1018-8827 1435-165X 1435-165X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3064921112 |
| source | MEDLINE; Applied Social Sciences Index & Abstracts (ASSIA); Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Age of onset Antidepressants Antipsychotics Anxiety disorders Attention deficit hyperactivity disorder Child Child and Adolescent Psychiatry Computerized medical records Conversion disorder DiGeorge Syndrome - complications DiGeorge Syndrome - psychology Disease Progression Drugs Electronic medical records Female Follow-Up Studies Hospitalization Humans Hyperactivity Intelligence tests Male Medical records Medicine Medicine & Public Health Mental disorders Occupational status Original Contribution Prodromal Symptoms Psychiatric hospitals Psychiatric symptoms Psychiatry Psychosis Psychotic Disorders Psychotic symptoms Psychotropic drugs Retrospective Studies Schizophrenia Social anxiety Social interactions Social isolation Stimulants Symptoms Unemployed people Young Adult |
| title | The clinical course of individuals with 22q11.2 deletion syndrome converting to psychotic disorders: a long-term retrospective follow-up |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T06%3A48%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20clinical%20course%20of%20individuals%20with%2022q11.2%20deletion%20syndrome%20converting%20to%20psychotic%20disorders:%20a%20long-term%20retrospective%20follow-up&rft.jtitle=European%20child%20&%20adolescent%20psychiatry&rft.au=Kulikova,%20Katerina&rft.date=2024-12-01&rft.volume=33&rft.issue=12&rft.spage=4371&rft.epage=4379&rft.pages=4371-4379&rft.issn=1018-8827&rft.eissn=1435-165X&rft_id=info:doi/10.1007/s00787-024-02469-9&rft_dat=%3Cproquest_cross%3E3064921112%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3140870437&rft_id=info:pmid/38834873&rfr_iscdi=true |