Role of Environmental Risk Factors in the Etiology of Inflammatory Bowel Diseases: A Multicenter Study
Background The increasing global incidence and prevalence of inflammatory bowel disease (IBD) necessitates an investigation into the potential influence of environmental risk factors on its origin. Aim This multicenter case-control study aimed to investigate potential environmental risk factors cont...
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| creator | Alperen, Cemile Cansu Soydas, Barıs Serin, Ender Erbayrak, Mustafa Savas, Nurten Akyurek Unler, Gulhan Kanat Meral, Cenk Emre Toprak, Ugur Boyacioglu, Ahmet Sedat Dagli, Ulku |
| description | Background
The increasing global incidence and prevalence of inflammatory bowel disease (IBD) necessitates an investigation into the potential influence of environmental risk factors on its origin.
Aim
This multicenter case-control study aimed to investigate potential environmental risk factors contributing to IBD development in Turkey.
Methods
The study included 156 Crohn’s disease (CD), 277 ulcerative colitis (UC) patients, and 468 controls (matched for age and gender) from six hospitals’ gastroenterology departments. Data collection relied on the International Organization of IBD’s questionnaire on environmental factors. Each environmental factor was initially analyzed using univariate and subsequently multivariate logistic regression models.
Results
In the multivariate model, regular coffee consumption was associated with decreased odds for both CD (OR 0.28; 95% CI 0.14–0.55) and UC (OR 0.25; 95% CI 0.15–0.42). Stress was associated with UC (OR 3.27; 95% CI 1.76–6.10) and CD (OR 4.40; 95% CI 2.12–9.10) development. A history of childhood infectious diseases (gastroenteritis, upper respiratory tract infections, etc.) raised the odds for both CD (OR 9.45; 95% CI 2.51–35.6) and UC (OR 7.56; 95% CI 1.57–36.4). Conversely, consuming well/spring water (OR 0.22; 95% CI 0.10–0.50) and childhood antibiotic use (OR 0.41; 95% CI 0.18–0.93) showed a positive association against UC. Increased consumption of refined sugar and industrial food products emerged as risk factors for IBD. Smoking increased the risk for CD (OR 2.38; 95% CI 1.16–4.91), while ex-smoking increased the risk for UC (OR 3.16; 95% CI 1.19–8.37).
Conclusions
This study represents the first multicenter case–control study in Turkey examining the effects of environmental factors on IBD. It revealed that coffee consumption is positively associated, while stress and childhood infection-related diseases are risk factors. These findings, which are not supported by other studies, provide insight into the relationships between these factors and IBD. |
| doi_str_mv | 10.1007/s10620-024-08491-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3064920423</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3095811976</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-8036867293f1d55f585bc2f2e05e000198b65de580b6e7a765fc2acf9bae70983</originalsourceid><addsrcrecordid>eNp9kU9vFDEMxaMK1C6FL9ADisSFy4CTbP71VsoWKrWqVOAcZWaddtrMpCQzrPbbk7IFJA6cbMk_Pz_5EXLE4B0D0O8LA8WhAb5swCwtazZ7ZMGkFg2XyjwjC2Cq9oypA_KilDsAsJqpfXIgjBGaMViQcJ0i0hToavzR5zQOOE4-0uu-3NMz300pF9qPdLpFupr6FNPN9pE-H0P0w-DrfEs_pA1G-rEv6AuWY3pCL-c49V2Vwky_TPN6-5I8Dz4WfPVUD8m3s9XX08_NxdWn89OTi6arlqfGgFBGaW5FYGspgzSy7XjgCBKre2ZNq-QapYFWofZaydBx3wXbetRgjTgkb3e6Dzl9n7FMbuhLhzH6EdNcnAC1tByWXFT0zT_oXZrzWN1VykrDmNWqUnxHdTmVkjG4h9wPPm8dA_eYgtul4GoK7lcKblOXXj9Jz-2A6z8rv99eAbEDSh2NN5j_3v6P7E-oCJIX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3095811976</pqid></control><display><type>article</type><title>Role of Environmental Risk Factors in the Etiology of Inflammatory Bowel Diseases: A Multicenter Study</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Alperen, Cemile Cansu ; Soydas, Barıs ; Serin, Ender ; Erbayrak, Mustafa ; Savas, Nurten Akyurek ; Unler, Gulhan Kanat ; Meral, Cenk Emre ; Toprak, Ugur ; Boyacioglu, Ahmet Sedat ; Dagli, Ulku</creator><creatorcontrib>Alperen, Cemile Cansu ; Soydas, Barıs ; Serin, Ender ; Erbayrak, Mustafa ; Savas, Nurten Akyurek ; Unler, Gulhan Kanat ; Meral, Cenk Emre ; Toprak, Ugur ; Boyacioglu, Ahmet Sedat ; Dagli, Ulku</creatorcontrib><description>Background
The increasing global incidence and prevalence of inflammatory bowel disease (IBD) necessitates an investigation into the potential influence of environmental risk factors on its origin.
Aim
This multicenter case-control study aimed to investigate potential environmental risk factors contributing to IBD development in Turkey.
Methods
The study included 156 Crohn’s disease (CD), 277 ulcerative colitis (UC) patients, and 468 controls (matched for age and gender) from six hospitals’ gastroenterology departments. Data collection relied on the International Organization of IBD’s questionnaire on environmental factors. Each environmental factor was initially analyzed using univariate and subsequently multivariate logistic regression models.
Results
In the multivariate model, regular coffee consumption was associated with decreased odds for both CD (OR 0.28; 95% CI 0.14–0.55) and UC (OR 0.25; 95% CI 0.15–0.42). Stress was associated with UC (OR 3.27; 95% CI 1.76–6.10) and CD (OR 4.40; 95% CI 2.12–9.10) development. A history of childhood infectious diseases (gastroenteritis, upper respiratory tract infections, etc.) raised the odds for both CD (OR 9.45; 95% CI 2.51–35.6) and UC (OR 7.56; 95% CI 1.57–36.4). Conversely, consuming well/spring water (OR 0.22; 95% CI 0.10–0.50) and childhood antibiotic use (OR 0.41; 95% CI 0.18–0.93) showed a positive association against UC. Increased consumption of refined sugar and industrial food products emerged as risk factors for IBD. Smoking increased the risk for CD (OR 2.38; 95% CI 1.16–4.91), while ex-smoking increased the risk for UC (OR 3.16; 95% CI 1.19–8.37).
Conclusions
This study represents the first multicenter case–control study in Turkey examining the effects of environmental factors on IBD. It revealed that coffee consumption is positively associated, while stress and childhood infection-related diseases are risk factors. These findings, which are not supported by other studies, provide insight into the relationships between these factors and IBD.</description><identifier>ISSN: 0163-2116</identifier><identifier>ISSN: 1573-2568</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-024-08491-w</identifier><identifier>PMID: 38837110</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adolescent ; Adult ; Biochemistry ; Case-Control Studies ; Coffee - adverse effects ; Colitis, Ulcerative - epidemiology ; Colitis, Ulcerative - etiology ; Crohn Disease - epidemiology ; Crohn Disease - etiology ; Crohn's disease ; Environmental Exposure - adverse effects ; Environmental risk ; Female ; Gastroenterology ; Hepatology ; Humans ; Inflammatory bowel disease ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Original Article ; Risk Factors ; Stress, Psychological - complications ; Stress, Psychological - epidemiology ; Transplant Surgery ; Turkey - epidemiology ; Young Adult</subject><ispartof>Digestive diseases and sciences, 2024-08, Vol.69 (8), p.2927-2936</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-8036867293f1d55f585bc2f2e05e000198b65de580b6e7a765fc2acf9bae70983</cites><orcidid>0000-0001-9227-0953</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-024-08491-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-024-08491-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38837110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alperen, Cemile Cansu</creatorcontrib><creatorcontrib>Soydas, Barıs</creatorcontrib><creatorcontrib>Serin, Ender</creatorcontrib><creatorcontrib>Erbayrak, Mustafa</creatorcontrib><creatorcontrib>Savas, Nurten Akyurek</creatorcontrib><creatorcontrib>Unler, Gulhan Kanat</creatorcontrib><creatorcontrib>Meral, Cenk Emre</creatorcontrib><creatorcontrib>Toprak, Ugur</creatorcontrib><creatorcontrib>Boyacioglu, Ahmet Sedat</creatorcontrib><creatorcontrib>Dagli, Ulku</creatorcontrib><title>Role of Environmental Risk Factors in the Etiology of Inflammatory Bowel Diseases: A Multicenter Study</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Background
The increasing global incidence and prevalence of inflammatory bowel disease (IBD) necessitates an investigation into the potential influence of environmental risk factors on its origin.
Aim
This multicenter case-control study aimed to investigate potential environmental risk factors contributing to IBD development in Turkey.
Methods
The study included 156 Crohn’s disease (CD), 277 ulcerative colitis (UC) patients, and 468 controls (matched for age and gender) from six hospitals’ gastroenterology departments. Data collection relied on the International Organization of IBD’s questionnaire on environmental factors. Each environmental factor was initially analyzed using univariate and subsequently multivariate logistic regression models.
Results
In the multivariate model, regular coffee consumption was associated with decreased odds for both CD (OR 0.28; 95% CI 0.14–0.55) and UC (OR 0.25; 95% CI 0.15–0.42). Stress was associated with UC (OR 3.27; 95% CI 1.76–6.10) and CD (OR 4.40; 95% CI 2.12–9.10) development. A history of childhood infectious diseases (gastroenteritis, upper respiratory tract infections, etc.) raised the odds for both CD (OR 9.45; 95% CI 2.51–35.6) and UC (OR 7.56; 95% CI 1.57–36.4). Conversely, consuming well/spring water (OR 0.22; 95% CI 0.10–0.50) and childhood antibiotic use (OR 0.41; 95% CI 0.18–0.93) showed a positive association against UC. Increased consumption of refined sugar and industrial food products emerged as risk factors for IBD. Smoking increased the risk for CD (OR 2.38; 95% CI 1.16–4.91), while ex-smoking increased the risk for UC (OR 3.16; 95% CI 1.19–8.37).
Conclusions
This study represents the first multicenter case–control study in Turkey examining the effects of environmental factors on IBD. It revealed that coffee consumption is positively associated, while stress and childhood infection-related diseases are risk factors. These findings, which are not supported by other studies, provide insight into the relationships between these factors and IBD.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biochemistry</subject><subject>Case-Control Studies</subject><subject>Coffee - adverse effects</subject><subject>Colitis, Ulcerative - epidemiology</subject><subject>Colitis, Ulcerative - etiology</subject><subject>Crohn Disease - epidemiology</subject><subject>Crohn Disease - etiology</subject><subject>Crohn's disease</subject><subject>Environmental Exposure - adverse effects</subject><subject>Environmental risk</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Inflammatory bowel disease</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Risk Factors</subject><subject>Stress, Psychological - complications</subject><subject>Stress, Psychological - epidemiology</subject><subject>Transplant Surgery</subject><subject>Turkey - epidemiology</subject><subject>Young Adult</subject><issn>0163-2116</issn><issn>1573-2568</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9vFDEMxaMK1C6FL9ADisSFy4CTbP71VsoWKrWqVOAcZWaddtrMpCQzrPbbk7IFJA6cbMk_Pz_5EXLE4B0D0O8LA8WhAb5swCwtazZ7ZMGkFg2XyjwjC2Cq9oypA_KilDsAsJqpfXIgjBGaMViQcJ0i0hToavzR5zQOOE4-0uu-3NMz300pF9qPdLpFupr6FNPN9pE-H0P0w-DrfEs_pA1G-rEv6AuWY3pCL-c49V2Vwky_TPN6-5I8Dz4WfPVUD8m3s9XX08_NxdWn89OTi6arlqfGgFBGaW5FYGspgzSy7XjgCBKre2ZNq-QapYFWofZaydBx3wXbetRgjTgkb3e6Dzl9n7FMbuhLhzH6EdNcnAC1tByWXFT0zT_oXZrzWN1VykrDmNWqUnxHdTmVkjG4h9wPPm8dA_eYgtul4GoK7lcKblOXXj9Jz-2A6z8rv99eAbEDSh2NN5j_3v6P7E-oCJIX</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Alperen, Cemile Cansu</creator><creator>Soydas, Barıs</creator><creator>Serin, Ender</creator><creator>Erbayrak, Mustafa</creator><creator>Savas, Nurten Akyurek</creator><creator>Unler, Gulhan Kanat</creator><creator>Meral, Cenk Emre</creator><creator>Toprak, Ugur</creator><creator>Boyacioglu, Ahmet Sedat</creator><creator>Dagli, Ulku</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9227-0953</orcidid></search><sort><creationdate>20240801</creationdate><title>Role of Environmental Risk Factors in the Etiology of Inflammatory Bowel Diseases: A Multicenter Study</title><author>Alperen, Cemile Cansu ; Soydas, Barıs ; Serin, Ender ; Erbayrak, Mustafa ; Savas, Nurten Akyurek ; Unler, Gulhan Kanat ; Meral, Cenk Emre ; Toprak, Ugur ; Boyacioglu, Ahmet Sedat ; Dagli, Ulku</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-8036867293f1d55f585bc2f2e05e000198b65de580b6e7a765fc2acf9bae70983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biochemistry</topic><topic>Case-Control Studies</topic><topic>Coffee - adverse effects</topic><topic>Colitis, Ulcerative - epidemiology</topic><topic>Colitis, Ulcerative - etiology</topic><topic>Crohn Disease - epidemiology</topic><topic>Crohn Disease - etiology</topic><topic>Crohn's disease</topic><topic>Environmental Exposure - adverse effects</topic><topic>Environmental risk</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Inflammatory bowel disease</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Risk Factors</topic><topic>Stress, Psychological - complications</topic><topic>Stress, Psychological - epidemiology</topic><topic>Transplant Surgery</topic><topic>Turkey - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alperen, Cemile Cansu</creatorcontrib><creatorcontrib>Soydas, Barıs</creatorcontrib><creatorcontrib>Serin, Ender</creatorcontrib><creatorcontrib>Erbayrak, Mustafa</creatorcontrib><creatorcontrib>Savas, Nurten Akyurek</creatorcontrib><creatorcontrib>Unler, Gulhan Kanat</creatorcontrib><creatorcontrib>Meral, Cenk Emre</creatorcontrib><creatorcontrib>Toprak, Ugur</creatorcontrib><creatorcontrib>Boyacioglu, Ahmet Sedat</creatorcontrib><creatorcontrib>Dagli, Ulku</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alperen, Cemile Cansu</au><au>Soydas, Barıs</au><au>Serin, Ender</au><au>Erbayrak, Mustafa</au><au>Savas, Nurten Akyurek</au><au>Unler, Gulhan Kanat</au><au>Meral, Cenk Emre</au><au>Toprak, Ugur</au><au>Boyacioglu, Ahmet Sedat</au><au>Dagli, Ulku</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Environmental Risk Factors in the Etiology of Inflammatory Bowel Diseases: A Multicenter Study</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>69</volume><issue>8</issue><spage>2927</spage><epage>2936</epage><pages>2927-2936</pages><issn>0163-2116</issn><issn>1573-2568</issn><eissn>1573-2568</eissn><abstract>Background
The increasing global incidence and prevalence of inflammatory bowel disease (IBD) necessitates an investigation into the potential influence of environmental risk factors on its origin.
Aim
This multicenter case-control study aimed to investigate potential environmental risk factors contributing to IBD development in Turkey.
Methods
The study included 156 Crohn’s disease (CD), 277 ulcerative colitis (UC) patients, and 468 controls (matched for age and gender) from six hospitals’ gastroenterology departments. Data collection relied on the International Organization of IBD’s questionnaire on environmental factors. Each environmental factor was initially analyzed using univariate and subsequently multivariate logistic regression models.
Results
In the multivariate model, regular coffee consumption was associated with decreased odds for both CD (OR 0.28; 95% CI 0.14–0.55) and UC (OR 0.25; 95% CI 0.15–0.42). Stress was associated with UC (OR 3.27; 95% CI 1.76–6.10) and CD (OR 4.40; 95% CI 2.12–9.10) development. A history of childhood infectious diseases (gastroenteritis, upper respiratory tract infections, etc.) raised the odds for both CD (OR 9.45; 95% CI 2.51–35.6) and UC (OR 7.56; 95% CI 1.57–36.4). Conversely, consuming well/spring water (OR 0.22; 95% CI 0.10–0.50) and childhood antibiotic use (OR 0.41; 95% CI 0.18–0.93) showed a positive association against UC. Increased consumption of refined sugar and industrial food products emerged as risk factors for IBD. Smoking increased the risk for CD (OR 2.38; 95% CI 1.16–4.91), while ex-smoking increased the risk for UC (OR 3.16; 95% CI 1.19–8.37).
Conclusions
This study represents the first multicenter case–control study in Turkey examining the effects of environmental factors on IBD. It revealed that coffee consumption is positively associated, while stress and childhood infection-related diseases are risk factors. These findings, which are not supported by other studies, provide insight into the relationships between these factors and IBD.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38837110</pmid><doi>10.1007/s10620-024-08491-w</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-9227-0953</orcidid></addata></record> |
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| subjects | Adolescent Adult Biochemistry Case-Control Studies Coffee - adverse effects Colitis, Ulcerative - epidemiology Colitis, Ulcerative - etiology Crohn Disease - epidemiology Crohn Disease - etiology Crohn's disease Environmental Exposure - adverse effects Environmental risk Female Gastroenterology Hepatology Humans Inflammatory bowel disease Male Medicine Medicine & Public Health Middle Aged Oncology Original Article Risk Factors Stress, Psychological - complications Stress, Psychological - epidemiology Transplant Surgery Turkey - epidemiology Young Adult |
| title | Role of Environmental Risk Factors in the Etiology of Inflammatory Bowel Diseases: A Multicenter Study |
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