Prognostic value of pulmonary artery diameter/aorta diameter ratio in patients with acute pulmonary embolism
Background The ratio of pulmonary artery diameter (PAD) to ascending aortic diameter (AoD) has been reported to be a prognostic marker in several lung diseases; however, the usefulness of this tool in patients with acute pulmonary embolism (APE) is unknown. Here, we aimed to determine the long-term...
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| Veröffentlicht in: | Herz 2024-12, Vol.49 (6), p.464-471 |
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| creator | Pay, Levent Çetin, Tuğba Keskin, Kıvanç Dereli, Şeyda Tezen, Ozan Yumurtaş, Ahmet Çağdaş Kolak, Zeynep Eren, Semih Şaylık, Faysal Çınar, Tufan Hayıroğlu, Mert İlker |
| description | Background
The ratio of pulmonary artery diameter (PAD) to ascending aortic diameter (AoD) has been reported to be a prognostic marker in several lung diseases; however, the usefulness of this tool in patients with acute pulmonary embolism (APE) is unknown. Here, we aimed to determine the long-term prognostic value of the PAD/AoD ratio in patients with APE.
Methods
A total of 275 patients diagnosed with APE at our tertiary care center between November 2016 and February 2022 were included in the study. The patients were divided into two groups according to the presence of long-term mortality and their PAD/AoD ratios were compared.
Results
Long-term mortality was observed in 48 patients during the median follow-up of 59 (39–73) months. The patients were divided into two groups for analysis: group 1, consisting of 227 patients without recorded mortality, and group 2, consisting of 48 patients with documented mortality. A multivariate Cox regression model indicated that the PAD/AoD ratio has the potential to predict long-term mortality (HR: 2.9116, 95% CI: 1.1544–7.3436,
p
= 0.023). Analysis of the receiver operating characteristic curve revealed that there was no discernible difference in discriminative ability between the simplified pulmonary embolism severity index (sPESI) and PAD/AoD ratio (area under the curve [AUC] = 0.679 vs. 0.684, respectively,
p
= 0.937). The long-term predictive ability of the PAD/AoD ratio was not inferior to the sPESI score.
Conclusions
The PAD/AoD ratio, which can be easily calculated from pulmonary computed tomography, may be a useful parameter for determining the prognosis of APE patients. |
| doi_str_mv | 10.1007/s00059-024-05251-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_3064582502</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3133566858</sourcerecordid><originalsourceid>FETCH-LOGICAL-p213t-d02d9b295c4b65436b1bbd4f10db711a6648fe714362e3f082a8e7706c18dd3d3</originalsourceid><addsrcrecordid>eNpdkUtLxTAQhYMoen38ARcScOOmOnk2XYr4AkEXug5pk2qlbWqSKv57o_f6wNWcYT4OM3MQ2idwTADKkwgAoiqA8gIEFaTga2hBJBGFlBVdRwtgHIqqYuUW2o7xGYCIisIm2mJKMVpxskD9XfCPo4-pa_Cr6WeHfYunuR_8aMI7NiG5XGxnBpfVifEhmZ8WB5M6j7sRT1m4MUX81qUnbJo5uT8ubqh938VhF220po9ub1V30MPF-f3ZVXFze3l9dnpTTJSwVFigtqppJRpeS8GZrEldW94SsHVJiJGSq9aVJE-oYy0oapQrS5ANUdYyy3bQ0dJ3Cv5ldjHpoYuN63szOj9HzUByoagAmtHDf-izn8OYt9OMMCakVEJl6mBFzfXgrJ5CN-TD9PcfM8CWQMyj8dGFXxsC-jMtvUxL57T0V1qasw_QU4Yg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3133566858</pqid></control><display><type>article</type><title>Prognostic value of pulmonary artery diameter/aorta diameter ratio in patients with acute pulmonary embolism</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Pay, Levent ; Çetin, Tuğba ; Keskin, Kıvanç ; Dereli, Şeyda ; Tezen, Ozan ; Yumurtaş, Ahmet Çağdaş ; Kolak, Zeynep ; Eren, Semih ; Şaylık, Faysal ; Çınar, Tufan ; Hayıroğlu, Mert İlker</creator><creatorcontrib>Pay, Levent ; Çetin, Tuğba ; Keskin, Kıvanç ; Dereli, Şeyda ; Tezen, Ozan ; Yumurtaş, Ahmet Çağdaş ; Kolak, Zeynep ; Eren, Semih ; Şaylık, Faysal ; Çınar, Tufan ; Hayıroğlu, Mert İlker</creatorcontrib><description>Background
The ratio of pulmonary artery diameter (PAD) to ascending aortic diameter (AoD) has been reported to be a prognostic marker in several lung diseases; however, the usefulness of this tool in patients with acute pulmonary embolism (APE) is unknown. Here, we aimed to determine the long-term prognostic value of the PAD/AoD ratio in patients with APE.
Methods
A total of 275 patients diagnosed with APE at our tertiary care center between November 2016 and February 2022 were included in the study. The patients were divided into two groups according to the presence of long-term mortality and their PAD/AoD ratios were compared.
Results
Long-term mortality was observed in 48 patients during the median follow-up of 59 (39–73) months. The patients were divided into two groups for analysis: group 1, consisting of 227 patients without recorded mortality, and group 2, consisting of 48 patients with documented mortality. A multivariate Cox regression model indicated that the PAD/AoD ratio has the potential to predict long-term mortality (HR: 2.9116, 95% CI: 1.1544–7.3436,
p
= 0.023). Analysis of the receiver operating characteristic curve revealed that there was no discernible difference in discriminative ability between the simplified pulmonary embolism severity index (sPESI) and PAD/AoD ratio (area under the curve [AUC] = 0.679 vs. 0.684, respectively,
p
= 0.937). The long-term predictive ability of the PAD/AoD ratio was not inferior to the sPESI score.
Conclusions
The PAD/AoD ratio, which can be easily calculated from pulmonary computed tomography, may be a useful parameter for determining the prognosis of APE patients.</description><identifier>ISSN: 0340-9937</identifier><identifier>ISSN: 1615-6692</identifier><identifier>EISSN: 1615-6692</identifier><identifier>DOI: 10.1007/s00059-024-05251-4</identifier><identifier>PMID: 38832941</identifier><language>eng</language><publisher>Heidelberg: Springer Medizin</publisher><subject>Acute Disease ; Aged ; Aorta ; Aorta - diagnostic imaging ; Cardiology ; Computed tomography ; Coronary vessels ; Diameters ; Embolism ; Embolisms ; Female ; Humans ; Internal Medicine ; Lung diseases ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mortality ; Original Articles ; Parameters ; Prognosis ; Pulmonary arteries ; Pulmonary artery ; Pulmonary Artery - diagnostic imaging ; Pulmonary Embolism - diagnosis ; Pulmonary Embolism - diagnostic imaging ; Pulmonary Embolism - mortality ; Pulmonary embolisms ; Quotients ; Regression models ; Retrospective Studies ; Severity of Illness Index</subject><ispartof>Herz, 2024-12, Vol.49 (6), p.464-471</ispartof><rights>The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2024</rights><rights>2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2024.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p213t-d02d9b295c4b65436b1bbd4f10db711a6648fe714362e3f082a8e7706c18dd3d3</cites><orcidid>0000-0002-7491-8119</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00059-024-05251-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00059-024-05251-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38832941$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pay, Levent</creatorcontrib><creatorcontrib>Çetin, Tuğba</creatorcontrib><creatorcontrib>Keskin, Kıvanç</creatorcontrib><creatorcontrib>Dereli, Şeyda</creatorcontrib><creatorcontrib>Tezen, Ozan</creatorcontrib><creatorcontrib>Yumurtaş, Ahmet Çağdaş</creatorcontrib><creatorcontrib>Kolak, Zeynep</creatorcontrib><creatorcontrib>Eren, Semih</creatorcontrib><creatorcontrib>Şaylık, Faysal</creatorcontrib><creatorcontrib>Çınar, Tufan</creatorcontrib><creatorcontrib>Hayıroğlu, Mert İlker</creatorcontrib><title>Prognostic value of pulmonary artery diameter/aorta diameter ratio in patients with acute pulmonary embolism</title><title>Herz</title><addtitle>Herz</addtitle><addtitle>Herz</addtitle><description>Background
The ratio of pulmonary artery diameter (PAD) to ascending aortic diameter (AoD) has been reported to be a prognostic marker in several lung diseases; however, the usefulness of this tool in patients with acute pulmonary embolism (APE) is unknown. Here, we aimed to determine the long-term prognostic value of the PAD/AoD ratio in patients with APE.
Methods
A total of 275 patients diagnosed with APE at our tertiary care center between November 2016 and February 2022 were included in the study. The patients were divided into two groups according to the presence of long-term mortality and their PAD/AoD ratios were compared.
Results
Long-term mortality was observed in 48 patients during the median follow-up of 59 (39–73) months. The patients were divided into two groups for analysis: group 1, consisting of 227 patients without recorded mortality, and group 2, consisting of 48 patients with documented mortality. A multivariate Cox regression model indicated that the PAD/AoD ratio has the potential to predict long-term mortality (HR: 2.9116, 95% CI: 1.1544–7.3436,
p
= 0.023). Analysis of the receiver operating characteristic curve revealed that there was no discernible difference in discriminative ability between the simplified pulmonary embolism severity index (sPESI) and PAD/AoD ratio (area under the curve [AUC] = 0.679 vs. 0.684, respectively,
p
= 0.937). The long-term predictive ability of the PAD/AoD ratio was not inferior to the sPESI score.
Conclusions
The PAD/AoD ratio, which can be easily calculated from pulmonary computed tomography, may be a useful parameter for determining the prognosis of APE patients.</description><subject>Acute Disease</subject><subject>Aged</subject><subject>Aorta</subject><subject>Aorta - diagnostic imaging</subject><subject>Cardiology</subject><subject>Computed tomography</subject><subject>Coronary vessels</subject><subject>Diameters</subject><subject>Embolism</subject><subject>Embolisms</subject><subject>Female</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Original Articles</subject><subject>Parameters</subject><subject>Prognosis</subject><subject>Pulmonary arteries</subject><subject>Pulmonary artery</subject><subject>Pulmonary Artery - diagnostic imaging</subject><subject>Pulmonary Embolism - diagnosis</subject><subject>Pulmonary Embolism - diagnostic imaging</subject><subject>Pulmonary Embolism - mortality</subject><subject>Pulmonary embolisms</subject><subject>Quotients</subject><subject>Regression models</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><issn>0340-9937</issn><issn>1615-6692</issn><issn>1615-6692</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtLxTAQhYMoen38ARcScOOmOnk2XYr4AkEXug5pk2qlbWqSKv57o_f6wNWcYT4OM3MQ2idwTADKkwgAoiqA8gIEFaTga2hBJBGFlBVdRwtgHIqqYuUW2o7xGYCIisIm2mJKMVpxskD9XfCPo4-pa_Cr6WeHfYunuR_8aMI7NiG5XGxnBpfVifEhmZ8WB5M6j7sRT1m4MUX81qUnbJo5uT8ubqh938VhF220po9ub1V30MPF-f3ZVXFze3l9dnpTTJSwVFigtqppJRpeS8GZrEldW94SsHVJiJGSq9aVJE-oYy0oapQrS5ANUdYyy3bQ0dJ3Cv5ldjHpoYuN63szOj9HzUByoagAmtHDf-izn8OYt9OMMCakVEJl6mBFzfXgrJ5CN-TD9PcfM8CWQMyj8dGFXxsC-jMtvUxL57T0V1qasw_QU4Yg</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Pay, Levent</creator><creator>Çetin, Tuğba</creator><creator>Keskin, Kıvanç</creator><creator>Dereli, Şeyda</creator><creator>Tezen, Ozan</creator><creator>Yumurtaş, Ahmet Çağdaş</creator><creator>Kolak, Zeynep</creator><creator>Eren, Semih</creator><creator>Şaylık, Faysal</creator><creator>Çınar, Tufan</creator><creator>Hayıroğlu, Mert İlker</creator><general>Springer Medizin</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TS</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7491-8119</orcidid></search><sort><creationdate>20241201</creationdate><title>Prognostic value of pulmonary artery diameter/aorta diameter ratio in patients with acute pulmonary embolism</title><author>Pay, Levent ; Çetin, Tuğba ; Keskin, Kıvanç ; Dereli, Şeyda ; Tezen, Ozan ; Yumurtaş, Ahmet Çağdaş ; Kolak, Zeynep ; Eren, Semih ; Şaylık, Faysal ; Çınar, Tufan ; Hayıroğlu, Mert İlker</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p213t-d02d9b295c4b65436b1bbd4f10db711a6648fe714362e3f082a8e7706c18dd3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acute Disease</topic><topic>Aged</topic><topic>Aorta</topic><topic>Aorta - diagnostic imaging</topic><topic>Cardiology</topic><topic>Computed tomography</topic><topic>Coronary vessels</topic><topic>Diameters</topic><topic>Embolism</topic><topic>Embolisms</topic><topic>Female</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Original Articles</topic><topic>Parameters</topic><topic>Prognosis</topic><topic>Pulmonary arteries</topic><topic>Pulmonary artery</topic><topic>Pulmonary Artery - diagnostic imaging</topic><topic>Pulmonary Embolism - diagnosis</topic><topic>Pulmonary Embolism - diagnostic imaging</topic><topic>Pulmonary Embolism - mortality</topic><topic>Pulmonary embolisms</topic><topic>Quotients</topic><topic>Regression models</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pay, Levent</creatorcontrib><creatorcontrib>Çetin, Tuğba</creatorcontrib><creatorcontrib>Keskin, Kıvanç</creatorcontrib><creatorcontrib>Dereli, Şeyda</creatorcontrib><creatorcontrib>Tezen, Ozan</creatorcontrib><creatorcontrib>Yumurtaş, Ahmet Çağdaş</creatorcontrib><creatorcontrib>Kolak, Zeynep</creatorcontrib><creatorcontrib>Eren, Semih</creatorcontrib><creatorcontrib>Şaylık, Faysal</creatorcontrib><creatorcontrib>Çınar, Tufan</creatorcontrib><creatorcontrib>Hayıroğlu, Mert İlker</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Herz</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pay, Levent</au><au>Çetin, Tuğba</au><au>Keskin, Kıvanç</au><au>Dereli, Şeyda</au><au>Tezen, Ozan</au><au>Yumurtaş, Ahmet Çağdaş</au><au>Kolak, Zeynep</au><au>Eren, Semih</au><au>Şaylık, Faysal</au><au>Çınar, Tufan</au><au>Hayıroğlu, Mert İlker</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of pulmonary artery diameter/aorta diameter ratio in patients with acute pulmonary embolism</atitle><jtitle>Herz</jtitle><stitle>Herz</stitle><addtitle>Herz</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>49</volume><issue>6</issue><spage>464</spage><epage>471</epage><pages>464-471</pages><issn>0340-9937</issn><issn>1615-6692</issn><eissn>1615-6692</eissn><abstract>Background
The ratio of pulmonary artery diameter (PAD) to ascending aortic diameter (AoD) has been reported to be a prognostic marker in several lung diseases; however, the usefulness of this tool in patients with acute pulmonary embolism (APE) is unknown. Here, we aimed to determine the long-term prognostic value of the PAD/AoD ratio in patients with APE.
Methods
A total of 275 patients diagnosed with APE at our tertiary care center between November 2016 and February 2022 were included in the study. The patients were divided into two groups according to the presence of long-term mortality and their PAD/AoD ratios were compared.
Results
Long-term mortality was observed in 48 patients during the median follow-up of 59 (39–73) months. The patients were divided into two groups for analysis: group 1, consisting of 227 patients without recorded mortality, and group 2, consisting of 48 patients with documented mortality. A multivariate Cox regression model indicated that the PAD/AoD ratio has the potential to predict long-term mortality (HR: 2.9116, 95% CI: 1.1544–7.3436,
p
= 0.023). Analysis of the receiver operating characteristic curve revealed that there was no discernible difference in discriminative ability between the simplified pulmonary embolism severity index (sPESI) and PAD/AoD ratio (area under the curve [AUC] = 0.679 vs. 0.684, respectively,
p
= 0.937). The long-term predictive ability of the PAD/AoD ratio was not inferior to the sPESI score.
Conclusions
The PAD/AoD ratio, which can be easily calculated from pulmonary computed tomography, may be a useful parameter for determining the prognosis of APE patients.</abstract><cop>Heidelberg</cop><pub>Springer Medizin</pub><pmid>38832941</pmid><doi>10.1007/s00059-024-05251-4</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7491-8119</orcidid></addata></record> |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Acute Disease Aged Aorta Aorta - diagnostic imaging Cardiology Computed tomography Coronary vessels Diameters Embolism Embolisms Female Humans Internal Medicine Lung diseases Male Medicine Medicine & Public Health Middle Aged Mortality Original Articles Parameters Prognosis Pulmonary arteries Pulmonary artery Pulmonary Artery - diagnostic imaging Pulmonary Embolism - diagnosis Pulmonary Embolism - diagnostic imaging Pulmonary Embolism - mortality Pulmonary embolisms Quotients Regression models Retrospective Studies Severity of Illness Index |
| title | Prognostic value of pulmonary artery diameter/aorta diameter ratio in patients with acute pulmonary embolism |
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