Extended haplotype with rs41524547-G defines the ancestral origin of SCA10

Abstract Spinocerebellar ataxia type 10 (SCA10) is a rare autosomal dominant ataxia caused by a large expansion of the (ATTCT)n repeat in ATXN10. SCA10 was described in Native American and Asian individuals which prompted a search for an expanded haplotype to confirm a common ancestral origin for th...

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Veröffentlicht in:	Human molecular genetics 2024-09, Vol.33 (18), p.1567-1574
Hauptverfasser:	McFarland, Karen N, Tiwari, Anjana, Hashem, Vera, Zhang, Linwei, Zeng, Desmond, Vincent, Justin, Arredondo, Maria J, Johnson, Kristy L, Gan, Shi Rui, Yabe, Ichiro, Skov, Laurits, Rasmussen, Astrid, Ashizawa, Tetsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Ataxin-10 - genetics DNA Repeat Expansion Gene Frequency Haplotypes - genetics Humans MicroRNAs - genetics Nerve Tissue Proteins - genetics Polymorphism, Single Nucleotide - genetics Spinocerebellar Ataxias - genetics
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