Scorpion venom heat-resistant synthesized peptide ameliorates epileptic seizures and imparts neuroprotection in rats mediated by NMDA receptors

Finding new and effective natural products for designing antiepileptic drugs is highly important in the scientific community. The scorpion venom heat-resistant peptide (SVHRP) was purified from Buthus martensii Karsch scorpion venom, and subsequent analysis of the amino acid sequence facilitated the...

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Veröffentlicht in:	European journal of pharmacology 2024-09, Vol.978, p.176704, Article 176704
Hauptverfasser:	Sui, Ao-Ran, Piao, Hua, Xiong, Si-Ting, Zhang, Peng, Guo, Song-Yu, Kong, Yue, Gao, Cheng-Qian, Wang, Zhi-Xue, Yang, Jun, Ge, Bi-Ying, Supratik, Kundu, Yang, Jin-Yi, Li, Shao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - chemistry Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Disease Models, Animal Epilepsy Epilepsy - chemically induced Epilepsy - drug therapy Hot Temperature Male Neurons - drug effects Neurons - metabolism Neurons - pathology Neuroprotective Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use NMDA receptor p38 Mitogen-Activated Protein Kinases - metabolism Pentylenetetrazole Peptides - chemistry Peptides - pharmacology Peptides - therapeutic use Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - metabolism Scorpion Venoms - chemistry Scorpion Venoms - pharmacology Seizures - drug therapy Seizures - prevention & control SVHRSP
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