CRISPR/Cas9-induced LEAP2 and GHSR1a knockout mutant zebrafish displayed abnormal growth and impaired lipid metabolism

•LEAP2 mutation promotes hepatic ghrelin and brain GHSR1a expression compared to wild-type zebrafish.•LEAP2 mutation leads to elevated feeding and increased liver fat in zebrafish, ultimately resulting in obesity in female zebrafish.•Overexpression of LEAP2 results in a higher expression of the appe...

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Veröffentlicht in:	General and comparative endocrinology 2024-09, Vol.355, p.114563, Article 114563
Hauptverfasser:	Fei, Yueyue, Bao, Zhonggui, Wang, Qin, Zhu, Yihong, Lu, Jigang, Ouyang, Linyue, Hu, Quiqin, Zhou, Yan, Chen, Liangbiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood glucose Fat GHSR1a LEAP2 Zebrafish
Online-Zugang:	Volltext
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