Up-regulation of systemic and local BDNF in non-allergic Nasal Polyps in China
Although the role of brain-derived neurotrophic factor (BDNF) in allergic rhinitis and/or nasal polyps (NPs) development has been studied, the contribution of BDNF in non-allergic NPs has not been evaluated yet. This study was to investigate the possible role of BDNF in non-allergic NPs pathogenesis...
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| Veröffentlicht in: | Pakistan journal of medical sciences 2024-06, Vol.40 (5), p.939-945 |
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| creator | Zhou, Xiangmin Zhang, Qian Wan, Yuzhu Shi, Li |
| description | Although the role of brain-derived neurotrophic factor (BDNF) in allergic rhinitis and/or nasal polyps (NPs) development has been studied, the contribution of BDNF in non-allergic NPs has not been evaluated yet. This study was to investigate the possible role of BDNF in non-allergic NPs pathogenesis.
The study was carried out at The Second Hospital of Shandong University from December 2020 to November 2021. The non-allergic NPs patients (n=26) and the control group (n=22) were included. Lund-Mackay CT scores, nasal endoscopy scores, and pulmonary function testing were evaluated before surgery. Tissue and serum levels of BDNF, eosinophil cationic protein (ECP), and cytokeratins 5 (CK5) were assessed between different groups.
The BDNF level in serum and tissue, CK5 count, and eosinophil infiltration in tissue were higher in non-allergic NPs. The eosinophils infiltration, ECP mRNA expression level, as well as BDNF mRNA level were increased in the BDNF
subgroup compared with BDNF
subgroup. Significantly negative correlations between BDNF count and the situation of airway obstruction were found in non-allergic NPs.
BDNF may have both local and systemic effects in non-allergic NPs pathogenesis. BDNF may be a possible therapeutic target or an indicator for eosinophilic NPs management. |
| doi_str_mv | 10.12669/pjms.40.5.7907 |
| format | Article |
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The study was carried out at The Second Hospital of Shandong University from December 2020 to November 2021. The non-allergic NPs patients (n=26) and the control group (n=22) were included. Lund-Mackay CT scores, nasal endoscopy scores, and pulmonary function testing were evaluated before surgery. Tissue and serum levels of BDNF, eosinophil cationic protein (ECP), and cytokeratins 5 (CK5) were assessed between different groups.
The BDNF level in serum and tissue, CK5 count, and eosinophil infiltration in tissue were higher in non-allergic NPs. The eosinophils infiltration, ECP mRNA expression level, as well as BDNF mRNA level were increased in the BDNF
subgroup compared with BDNF
subgroup. Significantly negative correlations between BDNF count and the situation of airway obstruction were found in non-allergic NPs.
BDNF may have both local and systemic effects in non-allergic NPs pathogenesis. BDNF may be a possible therapeutic target or an indicator for eosinophilic NPs management.</description><identifier>ISSN: 1682-024X</identifier><identifier>EISSN: 1681-715X</identifier><identifier>DOI: 10.12669/pjms.40.5.7907</identifier><identifier>PMID: 38827877</identifier><language>eng</language><publisher>Pakistan: Knowledge Bylanes</publisher><subject>Antibodies ; Asthma ; Brain-derived neurotrophic factor ; Cytokines ; Endoscopy ; Gene expression ; Hay fever ; Hyperplasia ; Immunoglobulins ; Localization ; Medical research ; Medicine, Experimental ; Nasal polyps ; Nurse practitioners ; Otolaryngology ; Polyps ; Proteins ; Rhinitis ; Sinuses</subject><ispartof>Pakistan journal of medical sciences, 2024-06, Vol.40 (5), p.939-945</ispartof><rights>Copyright: © Pakistan Journal of Medical Sciences.</rights><rights>COPYRIGHT 2024 Knowledge Bylanes</rights><rights>(c)2024 Pakistan Journal of Medical Sciences</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,862,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38827877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Xiangmin</creatorcontrib><creatorcontrib>Zhang, Qian</creatorcontrib><creatorcontrib>Wan, Yuzhu</creatorcontrib><creatorcontrib>Shi, Li</creatorcontrib><title>Up-regulation of systemic and local BDNF in non-allergic Nasal Polyps in China</title><title>Pakistan journal of medical sciences</title><addtitle>Pak J Med Sci</addtitle><description>Although the role of brain-derived neurotrophic factor (BDNF) in allergic rhinitis and/or nasal polyps (NPs) development has been studied, the contribution of BDNF in non-allergic NPs has not been evaluated yet. This study was to investigate the possible role of BDNF in non-allergic NPs pathogenesis.
The study was carried out at The Second Hospital of Shandong University from December 2020 to November 2021. The non-allergic NPs patients (n=26) and the control group (n=22) were included. Lund-Mackay CT scores, nasal endoscopy scores, and pulmonary function testing were evaluated before surgery. Tissue and serum levels of BDNF, eosinophil cationic protein (ECP), and cytokeratins 5 (CK5) were assessed between different groups.
The BDNF level in serum and tissue, CK5 count, and eosinophil infiltration in tissue were higher in non-allergic NPs. The eosinophils infiltration, ECP mRNA expression level, as well as BDNF mRNA level were increased in the BDNF
subgroup compared with BDNF
subgroup. Significantly negative correlations between BDNF count and the situation of airway obstruction were found in non-allergic NPs.
BDNF may have both local and systemic effects in non-allergic NPs pathogenesis. BDNF may be a possible therapeutic target or an indicator for eosinophilic NPs management.</description><subject>Antibodies</subject><subject>Asthma</subject><subject>Brain-derived neurotrophic factor</subject><subject>Cytokines</subject><subject>Endoscopy</subject><subject>Gene expression</subject><subject>Hay fever</subject><subject>Hyperplasia</subject><subject>Immunoglobulins</subject><subject>Localization</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Nasal polyps</subject><subject>Nurse practitioners</subject><subject>Otolaryngology</subject><subject>Polyps</subject><subject>Proteins</subject><subject>Rhinitis</subject><subject>Sinuses</subject><issn>1682-024X</issn><issn>1681-715X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkUtr3DAUhUVpaB7turtiKJRs7Fy9LHmZTJI2EKZdNJCdUGRpxoMsuZa9mH9fOUkfKUUCCZ3vXK7uQeg9hgqTum7Ohl2fKgYVr0QD4hU6wrXEpcD8_vXjnZRA2P0hOk5pB8BqxskbdEilJEIKcYTWd0M52s3s9dTFUERXpH2abN-ZQoe28NFoX1xcrq-LLhQhhlJ7b8dNltc6Zelb9PshLeJq2wX9Fh047ZN993yeoLvrq--rL-Xt1883q_Pb0jAsp9IxEJJKCtqRmtAGW9Iaza11QoKhzuA2N8iY4Q04ajnopgXBHgh1FkQL9ASdPtUdxvhjtmlSfZeM9V4HG-ekKNQMs7x5Rj_-g-7iPIbcXaY451hyDn-ojfZWdcHFadRmKarORcOAENHITFX_ofJql4nFYF2X318YPv1l2Frtp22Kfl6GnV6CZ0-gGWNKo3VqGLtej3uFQT1GrZaoFQPF1RJ1dnx4_tf80Nv2N_8rW_oTr4Sg0A</recordid><startdate>20240630</startdate><enddate>20240630</enddate><creator>Zhou, Xiangmin</creator><creator>Zhang, Qian</creator><creator>Wan, Yuzhu</creator><creator>Shi, Li</creator><general>Knowledge Bylanes</general><general>AsiaNet Pakistan (Pvt) Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20240630</creationdate><title>Up-regulation of systemic and local BDNF in non-allergic Nasal Polyps in China</title><author>Zhou, Xiangmin ; Zhang, Qian ; Wan, Yuzhu ; Shi, Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-f40783830af262391e2dca5eef780c3fc1d82744c590f3e50a9d074b23fe07d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antibodies</topic><topic>Asthma</topic><topic>Brain-derived neurotrophic factor</topic><topic>Cytokines</topic><topic>Endoscopy</topic><topic>Gene expression</topic><topic>Hay fever</topic><topic>Hyperplasia</topic><topic>Immunoglobulins</topic><topic>Localization</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Nasal polyps</topic><topic>Nurse practitioners</topic><topic>Otolaryngology</topic><topic>Polyps</topic><topic>Proteins</topic><topic>Rhinitis</topic><topic>Sinuses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Xiangmin</creatorcontrib><creatorcontrib>Zhang, Qian</creatorcontrib><creatorcontrib>Wan, Yuzhu</creatorcontrib><creatorcontrib>Shi, Li</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pakistan journal of medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Xiangmin</au><au>Zhang, Qian</au><au>Wan, Yuzhu</au><au>Shi, Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Up-regulation of systemic and local BDNF in non-allergic Nasal Polyps in China</atitle><jtitle>Pakistan journal of medical sciences</jtitle><addtitle>Pak J Med Sci</addtitle><date>2024-06-30</date><risdate>2024</risdate><volume>40</volume><issue>5</issue><spage>939</spage><epage>945</epage><pages>939-945</pages><issn>1682-024X</issn><eissn>1681-715X</eissn><abstract>Although the role of brain-derived neurotrophic factor (BDNF) in allergic rhinitis and/or nasal polyps (NPs) development has been studied, the contribution of BDNF in non-allergic NPs has not been evaluated yet. This study was to investigate the possible role of BDNF in non-allergic NPs pathogenesis.
The study was carried out at The Second Hospital of Shandong University from December 2020 to November 2021. The non-allergic NPs patients (n=26) and the control group (n=22) were included. Lund-Mackay CT scores, nasal endoscopy scores, and pulmonary function testing were evaluated before surgery. Tissue and serum levels of BDNF, eosinophil cationic protein (ECP), and cytokeratins 5 (CK5) were assessed between different groups.
The BDNF level in serum and tissue, CK5 count, and eosinophil infiltration in tissue were higher in non-allergic NPs. The eosinophils infiltration, ECP mRNA expression level, as well as BDNF mRNA level were increased in the BDNF
subgroup compared with BDNF
subgroup. Significantly negative correlations between BDNF count and the situation of airway obstruction were found in non-allergic NPs.
BDNF may have both local and systemic effects in non-allergic NPs pathogenesis. BDNF may be a possible therapeutic target or an indicator for eosinophilic NPs management.</abstract><cop>Pakistan</cop><pub>Knowledge Bylanes</pub><pmid>38827877</pmid><doi>10.12669/pjms.40.5.7907</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; PubMed Central; Alma/SFX Local Collection |
| subjects | Antibodies Asthma Brain-derived neurotrophic factor Cytokines Endoscopy Gene expression Hay fever Hyperplasia Immunoglobulins Localization Medical research Medicine, Experimental Nasal polyps Nurse practitioners Otolaryngology Polyps Proteins Rhinitis Sinuses |
| title | Up-regulation of systemic and local BDNF in non-allergic Nasal Polyps in China |
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