Verapamil increases susceptibility of colistin-resistant Acinetobacter baumannii to colistin

•The combination of verapamil and colistin showed synergistic efficacy against colistin-resistant Acinetobacter baumannii both in vitro and in vivo.•Provide new possible approaches and strategies to combat resistance to colistin.•Enhance the antibacterial activity of colistin and reduce the amount o...

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Veröffentlicht in:	International journal of antimicrobial agents 2024-08, Vol.64 (2), p.107233, Article 107233
Hauptverfasser:	Liu, Sichen, Zhou, Huijing, Kong, Jingchun, Chen, Huanchang, Chen, Lei, Tang, Miran, Zhou, Beibei, Xu, Mengxin, Chen, Lijiang, Zhou, Tieli
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinetobacter baumannii Acinetobacter baumannii - drug effects Acinetobacter Infections - drug therapy Acinetobacter Infections - microbiology Animals Anti-Bacterial Agents - pharmacology Antimicrobial synergy Biofilms - drug effects Colistin - pharmacology Drug Resistance, Bacterial - drug effects Drug Synergism Humans Microbial Sensitivity Tests Microbial Viability - drug effects Reactive Oxygen Species - metabolism Verapamil Verapamil - pharmacology
Online-Zugang:	Volltext
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